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Filters: Date: "2007" Department: "Biology" Collection: "ir_uspace"
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1 Olivera, Baldomero M.?O-Conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2The ?O-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (NaV1.8) and could therefore ...2007
2 Jorgensen, ErikAxons break in animals lacking B-spectrinAxons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break.2007
3 Bastiani, MichaelAxons break in animals lacking β-spectrinAxons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break.Mutants; Dendrites; Morphology2007
4 Coley, Phyllis D.Beneficios y costos de defensa en un arbusto del neotrópicoLOS beneficios y costos son de importancia capital para las teorfas de optimization de las defensas de las plantas. El beneficio es la ganancia de aptitud para reducir el herbivorismo; el costo es la perdida de aptitud al comprometer recursos en defensa. Evaluamos los beneficios y los costos de def...Psychotria horizontalis; Isla de Barro Colorado; Costos de defense; Celdas de exclusion; Herbivorismo; Defensa de las plantas; Taninos; Dureza; Tropicos; Benefit; Beneficios2007
5 Beckerle, Mary C.Cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiationIn this report, an antisense RNA strategy has allowed us to show that disruption of ALP expression affects the expression of the muscle transcription factors myogenin and MyoD, resulting in the inhibition of muscle differentiation. Introduction of a MyoD expression construct into ALP-antisense cells...Skeletal muscle; PDZ-LIM protein; Actin; Actinin-associated LIM proteins; Serum response factor; Cytoskeletal architecture2007
6 Farmer, Colleen G.Dendrobates auratus (green and black poison dart frog). Larval PredationDendrobates auratus was intentionally introduced onto the island of O'ahu, Hawai'i in 1932 from Taboga Island, Panama for mosquito control. Phelsuma laticauda was accidentally introduced from Madagascar in 1996 to the University of Hawaii at Manoa. Both species are well established in the Manoa Val...Dendrobates auratus; Phelsuma laticauda2007
7 Coley, Phyllis D.Disponibilidad de recursos y defensas de las plantas frente al herbivorismoEl grado de herbivorismo y la eficacia de las defensas muestran amplias variaciones en las especies de plantas. La disponibilidad de recursos en el ambiente se propone como el mayor determinante de la cantidad y tipo de defensas de las plantas. Cuando los recursos son limitados, las plantas de cre...Defensas; Plantas; Herbivorismo2007
8 Hultine, Kevin; Bush, Sarah Elizabeth; Ehleringer, James R.Effect of gender on sap-flux-scaled transpiration in a dominant riparian tree species: Box elder (Acer negundo)Acer negundo is a dioecious riparian tree species with a spatial segregation of the sexes along soil moisture gradients. Females are typically more common in wet sites along streams (typically F/M = 1.6), whereas males are more common in drier sites away from streams (typically F/M = 0.6). Spatial s...Density; Ecosystem; Segregation2007
9 Sperry, John S.Hydraulic consequences of vessel evolution in angiospermsWe tested two hypotheses for how vessel evolution in angiosperms influenced xylem function. First, the transition to vessels decreased resistance to flow--often considered the driving force for their evolution. Second, the transition to vessels compromised safety from cavitation--a constraint emergi...Cavitation; Resistivity; Perforation2007
10 Adler, Frederick R.; Liou, Theodore G.; Cahill, Barbara C.Lung transplantation and survival in children with cystic fibrosisThe effects of lung transplantation on the survival and quality of life in children with cystic fibrosis are uncertain. We used data from the U.S. Cystic Fibrosis Foundation Patient Registry and from the Organ Procurement and Transplantation Network to identify children with cystic fibrosis who were...Life; Infection; Risk; Harm2007
11 Adler, Frederick R.; Feener, Donald H.Maintaining diversity in an ant community: modeling, extending, and testing the dominance-discovery trade-offAnt communities often consist of many species with apparently similar niches. We present a mathematical model of the dominance-discovery trade-off, the trade-off between the abilities to find and to control resources, showing that it can in principle facilitate the coexistence of large numbers of s...Coexistence; Dominant species; Parasitoid2007
12 Hughes, Kelly T.; Chevance, FabienneMechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolutionThe rod component of the bacterial flagellum polymerizes from the inner membrane across the periplasmic space and stops at a length of 25 nm at the outer membrane. Bushing structures, the P- and L-rings, polymerize around the distal rod and form a pore in the outer membrane. The flagellar hook stru...Flagellar assembly; Spirochete evolution; Membrane penetration2007
13 Capecchi, Mario R.Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanomaAngiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10...Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme2007
14 Jorgensen, ErikMolecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2Synaptic transmission depends on clathrin-mediated recycling of synaptic vesicles (SVs). How select SV proteins are targeted for internalization has remained elusive. Stonins are evolutionarily conserved adaptors dedicated to endocytic sorting of the SV protein synaptotagmin. Our data identify the m...2007
15 Olivera, Baldomero M.; Bandyopadhyay, Pradip K.Molecular phylogeny of some Indo-Pacific genera in the subfamily Turrinae H. Adams and A. Adams, 1853 (1838) (Gastropoda: Neogastropoda)We have carried out a phylogenetic analysis of a group of Indo-Pacific species in the subfamily Turrinae (Swainson, 1840) using 128 mitoehondrial ribosomal RNA gene sequcnces Most of the species analyzed are convenlionally assigned to one of there Lophiotoma Casey, 1904. The inolecular anaysis revea...Turrinae; Indo-Pacific; Mitochondrial RNA; Molecular phylogeny2007
16 Olivera, Baldomero M.; Bulaj, GrzegorzNovel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptorsWe report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3) contains 19 amino acids with three γ-carboxyglutamate (Gla) residues, a post-translationally modified amino acid characteristic of conantokins. The...Conotoxins; Conantokins; Conus parius; Antagonists; n-methyl-D-aspartate receptors2007
17 Jorgensen, ErikOpen syntaxin docks synaptic vesiclesSynaptic vesicles dock to the plasma membrane at synapses to facilitate rapid exocytosis. Docking was originally proposed to require the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) proteins; however, perturbation studies suggested that docking was independent of the...2007
18 Bohs, Lynn A.Phylogeny of Balsamorhiza and Wyethia (Asteraceae: Heliantheae) using ITS, ETS, and trnK sequence dataBalsamorhiza and Wyethia together comprise 24 species native to western North America. All species in the two genera are perennial herbs with large taproots and chromosome base numbers of x = 19. The species of Balsamorhiza have exclusively basal leaves while the species of Wyethia have cauline leav...Balsamorhiza; Wyethia; Asteraceae; Engelmanniinae; nuclear ribosomal DNA2007
19 Bohs, Lynn A.Phylogeny of the Cyphomandra clade of the genus Solanum (Solanaceae) based on ITS sequence data13 major clades can be recognized within the genus Solatium (Solanaceae) based on chloroplast DNA sequence data. One of these is the Cyphomandra clade, which includes about 50 neotropical species. These have traditionally been placed into two or three sections: S. section Pachyphylla (formerly recog...Cyphomandra; ITS; osmophores; self-incompatibility; Solanum2007
20 Olivera, Baldomero M.; Zhang, MinMin; Azam, Layla; Yoshikami, Doju; Bulaj, GrzegorzStructure/function characterization of μ-Conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channelsPeptide neurotoxins from cone snails continue to supply compounds with therapeutic potential. Although several analgesic conotoxins have already reached human clinical trials, a continuing need exists for the discovery and development of novel nonopioid analgesics, such as subtype-selective sodium c...Conotoxins; 956;-Conotoxin KIIIA; Neuronal blocker; Neurotoxins; Sodium channel blockers2007
21 Bohs, Lynn A.Three-gene phylogeny of the genus Solanum (Solanaceae)Solanum, with approximately 1,500 species, is the largest genus in the Solanaceae and includes economically important species such as the tomato, potato, and eggplant. In part due to its large size and tropical center of diversity, resolving evolutionary relationships across Solanum as a whole has ...ndhF; trnT-F; Waxy; Solanum; Cyphomandra2007
22 Sperry, John S.Water transport in vesselless angiosperms: conducting efficiency and cavitation safetyTwo structure-function hypotheses were tested for vesselless angiosperm wood. First, vesselless angiosperm wood should have much higher flow resistance than conifer wood because angiosperm tracheids lack low-resistance torus-margo pits. Second, vesselless wood ought to be exceptionally safe from cav...2007
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