Creator | Title | Description | Subject | Date | ||
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1 | Blumenthal, Donald K. | C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. | We present structural data on the RI alpha isoform of the cAMP-dependent protein kinase A that reveal, for the first time, a large scale conformational change within the RI alpha homodimer upon catalytic subunit binding. This result infers that the inhibition of catalytic subunit activity is not the... | Protein Kinase; cAMP | 2004-04-30 |