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Filters: Date: "2004" School Or College: "School of Medicine" Collection: "ir_uspace"
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1 Gesteland, Raymond F.; Atkins, John F.; Wills, Norma M.-1 frameshifting at a CGA AAG hexanucleotide site is required for transposition of insertion sequence IS1222The discovery of programmed _x0001_1 frameshifting at the hexanucleotide shift site CGA_AAG, in addition to the classical X_XXY_YYZ heptanucleotide shift sequences, prompted a search for instances among eubacterial insertion sequence elements. IS1222 has a CGA_AAG shift site. A genetic analysis re...Hexanucleotides; Heptanucleotides; Frameshifting2004
2 Kestle, John R. W.; Walker, Marion L.Adjustment and malfunction of a programmable valve after exposure to toy magnetsInadvertent adjustments and malfunctions of programmable valves have been reported in cases in which patients have encountered powerful electromagnetic fields such as those involved in magnetic resonance imaging, but the effects of small magnetic fields are not well known. The authors present a ca...2004
3 Schmidt, Meic H.Cavernous hemangioma of the skull presenting with subdural hematomaCavernous hemangioma of the calvaria is a very rare disease, and patients usually present with headaches or a visible skull deformity. Few reports of patients presenting with intradiploic or epidural hemorrhages are found in the literature. No case of an intradural hemorrhage from a cavernous hemang...Calvaria; Cavernous hemangioma2004
4 Normann, Richard A.; Shoham, ShyCoding of position by simultaneously recorded sensory neurones in the cat dorsal root ganglionMuscle, cutaneous and joint afferents continuously signal information about the position and movement of individual joints. How does the nervous system extract more global information, for example about the position of the foot in space? To study this question we used microelectrode arrays to record...Cats; Sensory Neurones; Movement; Limb Position2004
5 Couldwell, William T.Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumorsObject. The optimal management of glomus jugulare tumors remains controversial. Available treatments were once associated with poor outcomes and significant complication rates. Advances in skull base surgery and the delivery of radiation therapy by stereotactic radiosurgery have improved the results...2004
6 Kestle, John R. W.; Brockmeyer, Douglas LeeComplications of intracranial pressure monitoring in children with head traumaObject. Intracranial pressure (ICP) monitoring has become routine in the management of patients with traumatic brain injury (TBI). Many surgeons prefer to use external ventricular drains (EVDs) over fiberoptic monitors to measure ICP because of the added benefit of cerebrospinal fluid drainage. The ...Head trauma; Ventriculostomy; External ventricular drain; Monitoring; Fiberoptic monitor2004
7 Gardner, Reed M.Computerized Clinical Decision-Support in Respiratory CareBiomedical Informatics2004
8 Olson, Randall J.Early experiences with microphacoMicrophaco is the separation of irrigation from aspiration that allows removal of cataracts through sub-2mm incisions. While proven intraocular lenses (IOLs) are not available at this time to take advantage of the small wounds, these wounds are advantageous from a separating irrigation standpoint w...Microphaco; Cataracts; Irrigation; Wounds2004
9 Kestle, John R. W.; MacDonald, Joel D.; Couldwell, William T.Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasmObject. Cerebral vasospasm that is caused by aneurysmal subarachnoid hemorrhage and that is refractory to maximal medical management can be treated with selective intraarterial papaverine infusions. The effects of single papaverine treatments on cerebral circulation time are well known. The purpose ...Cerebral vasospasm; Intraarterial papaverine infusions2004
10 Gesteland, Raymond F.; Atkins, John F.; Howard, Michael T.Efficient stimulation of site-specific ribosome frameshifting by antisense oligonucleotidesEvidence is presented that morpholino, 2_x0001_-O-methyl, phosphorothioate, and RNA antisense oligonucleotides can direct sitespecific âˆ'1 translational frameshifting when annealed to mRNA downstream from sequences where the P- and A-site tRNAs are both capable of re-pairing with âˆ'1 frame c...Recoding; Frameshifting; Antisense; Morpholino; Phosphorothioate; 2_x0001_-O-methyl2004
11 Normann, Richard A.; Shoham, ShyEncoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglionRecent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ...Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle2004
12 Fuhrmann, SabineExpression of CNTF receptor-alpha in chick violet-sensitive cones with unique morphologic properties.PURPOSE: Application of ciliary neurotrophic factor (CNTF) can rescue mature photoreceptors from lesion-induced and hereditary degeneration. In the chick retina, expression of the CNTF receptor is present in a subpopulation of photoreceptor cells. The present study was undertaken to identify the CNT...embryology; cytology2004
13 Zhang, KangExpression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viabilityPURPOSE: ELOVL4 is a member of the fatty acid elongase (ELO) family of genes. Mutations of this gene are responsible for autosomal dominant Stargardt-like macular degeneration. However, the specific role of ELOVL4 in photoreceptor cells and the mechanism by which mutations in ELOVL4 causes macular d...Endoplasmic Reticulum; Green Fluorescent Proteins; Microscopy, Fluorescence2004
14 Couldwell, William T.; Schloesser, Peter E.Hemorrhage from moyamoya-like vessels associated with a cerebral arteriovenous malformationThe authors describe a case of subarachnoid hemorrhage from moyamoya-like vessels associated with an arteriovenous malformation (AVM) in a 44-year-old Hispanic man who presented with severe headache. The AVM was located in the left parietal lobe and the ipsilateral middle cerebral artery was occlude...Moyamoya-like vessels; Arteriovenous malformation; Ischemia MeSH: Arteriovenous malformations2004
15 Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S.Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eyeUptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio...Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls2004
16 Kestle, John R. W.; Townsend, Jeannette J.; Brockmeyer, Douglas LeeJuvenile pilocytic astrocytoma of the brainstem in childrenObject. In reports involving the operative treatment of brainstem tumors, multiple histological types are often grouped together. To determine prognosis after resection, histology-specific data may be helpful. Methods. Twenty-eight patients with juvenile pilocytic astrocytoma (JPA) of the brainste...Juvenile pilocytic astrocytoma; JPA; Brainstem tumors; Resection2004
17 Baehr, WolfgangLecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liverLecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling system that replenis...Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Microscopy, Fluorescence2004
18 Normann, Richard A.; Branner, AlmutLong-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerveWe studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions o...Cats; Microelectrodes; Prosthesis Implantation; Sciatic Nerve2004
19 Bernstein, Paul S.; Gellermann, WernerMacular pigment Raman detector for clinical applicationsClinical studies of carotenoid macular pigments (MP) have been limited by the lack of noninvasive, objective instruments. We introduce a novel noninvasive optical instrument, an MP Raman detector, for assessment of the carotenoid status of the human retina in vivo. The instrument uses resonant excit...Diagnosis, Computer-Assisted; Equipment Failure Analysis; Sensitivity and Specificity2004
20 Kestle, John R. W.; MacDonald, Joel D.; Schmidt, Richard H.Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhageObject. Cerebral vasospasm after subarachnoid hemorrhage (SAH) continues to be a major source of morbidity in patients despite significant clinical and basic science research. Efforts to prevent vasospasm by removing spasmogens from the subarachnoid space have produced mixed results. The authors hyp...Cerebral vasospasm; Lumbar drainage2004
21 Couldwell, William T.Medical and surgical management of microprolactinomaA recent report by Colao et al. [1] indicates that a significant proportion of patients harboring prolactinomas treated with cabergoline will have persistence of remission of hyperprolactinemia following withdrawal of the drug. The prolactin and tumor control rates in the study suggest that medical ...Microprolactinoma; Prolactinoma; Cabergolene2004
22 Zhang, Kang; Yang, Zhenglin; Jiang, LiMutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11qFamilial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Autosomal dominant FEVR is genetically heterogeneous, but its principal locus, EVR1, is on chromosome 11q13-q23. The gene encoding the Wnt receptor frizzled-4 (FZD4) was recently reported ...Familial exudative vitreoretinopathy; FEVR; Inherited blinding disorders2004
23 Couldwell, William T.Neurosurgical implications of allergic fungal sinusitisObject. Allergic fungal sinusitis (AFS) is a form of paranasal mycosis that often involves bone destruction and extension into the orbit and anterior skull base. Treatment consists of surgical extirpation and a course of corticosteroids. Despite frequent intracranial involvement, AFS is rarely repor...2004
24 Baehr, WolfgangNoninvasive two-photon imaging reveals retinyl ester storage structures in the eyeVisual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal. The regeneration of preillumination conditions of the photoreceptor cells requires formation of 11-cis-retinal in t...Microscopy, Fluorescence; Visual Perception; Membrane Proteins2004
25 Couldwell, William T.; Orlandi, Richard R.; Apfelbaum, Ronald I.Novel closure technique for the endonasal transsphenoidal approach: Technical noteTranssphenoidal microsurgery has been the standard approach to sellar lesions since the repopularization of the technique with modifications by Dott, Guiot, and Hardy. The endonasal transseptal transsphenoidal approach, as introduced by Hirsch, is still commonly used by pituitary surgeons to remove ...2004
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