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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
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Baehr, Wolfgang | Cloning of frog rod photoreceptor cGMP phosphodiesterase subunits (P-alpha, P-beta, P-gamma) and identification of P-gamma) sites involved in the stimulation of cGMP binding to P-alpha and P-beta non-catalytic sites | Retinal cGMP phosphodiesterase (PDE6) is a key enzyme in vertebrate phototransduction. Rod PDE contains two homologous catalytic subunits (Pd two identical regulatory subunits (P). Biochemical studies have shown that amphibian P has high affinity, cGMP-specific, non-catalytic binding sites and that ... | Phototransduction; Retinal cGMP phosphodiesterase; Amphibian PDE | 2002 |
| 2 |
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Gesteland, Raymond F.; Wills, Norma M.; Atkins, John F. | Comparative studies of frameshifting and nonframeshifting RNA pseudoknots: a mutational and NMR investigation of pseudoknots derived from the bacteriophage T2 gene 32 mRNA and the retroviral gag-pro frameshift site | Mutational and NMR methods were used to investigate features of sequence, structure, and dynamics that are associated with the ability of a pseudoknot to stimulate a "1 frameshift. In vitro frameshift assays were performed on retroviral gag-pro frameshift-stimulating pseudoknots and their derivati... | Frameshifting; NMR; Pseudoknot; Retrovirus | 2002 |
| 3 |
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Dailey, Andrew T.; Brodke, Darrel S. | Comparison of computerized tomography and direct visualization in thoracic pedicle screw placement | Object. To validate computerized tomography (CT) scanning as a tool to assess the accuracy of thoracic pedicle screw placement, the authors compared its accuracy with that of direct visualization in instrumented cadaveric spine specimens. Methods. A grading scale was devised to score the placement... | Computerized tomography; Direct visualization; Thoracic pedicle screw; Pedicle; Thoracic spine | 2002 |
| 4 |
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Kestle, John R. W. | Cost-effectiveness analysis of endoscopic third ventriculostomy | OBJECTIVE: Endoscopic third ventriculostomy (ETV) is currently the principal alternative to cerebrospinal fluid shunt placement in the management of pediatric hydrocephalus. Cost-effectiveness analysis can help determine the optimal strategy for integrating these different approaches. METHODS: All... | Endoscopic third ventriculostomy; ETV | 2002 |
| 5 |
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Kestle, John R. W. | Death after late failure of third ventriculostomy in children | Late failure following successful third ventriculostomy for obstructive hydrocephalus is rare, and death caused by failure of a previously successful third ventriculostomy has been reported only once. The authors present three patients who died as a result of increased intracranial pressure (ICP) a... | Ventriculostomy; Obstructive hydrocephalus; Late failure; Death | 2002 |
| 6 |
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Bernstein, Paul S.; Leppert, Mark F. | Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings | PURPOSE: Single-copy variants of the autosomal recessive Stargardt disease (STGD1) gene ABCR (ABCA4) have been shown to confer enhanced susceptibility to age-related macular degeneration (AMD). To investigate the role of ABCR alleles in AMD further, genotype-phenotype analysis was performed on sibli... | DNA Mutational Analysis; Nuclear Family; Phenotype | 2002 |
| 7 |
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Couldwell, William T. | Hearing restoration after resection of an intracanalicular vestibular schwannoma: a role for emergency surgery? | Patients with vestibular schwannomas (VSs) most commonly present with sensorineural hearing loss, which is often insidious or gradual. Up to 26% of patients may present with sudden hearing loss, however, which poses an important surgical challenge. Sudden hearing loss has been attributed to spasm or... | Vestibular schwannoma; Hearing preservation | 2002 |
| 8 |
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Gesteland, Raymond F.; Atkins, John F. | Influence of the stacking potential of the base 3' of tandem shift codons on -1 ribosomal frameshifting used for gene expression | Translating ribosomes can shift reading frame at specific sites with high efficiency for gene expression purposes. The most common type of shift to the 1 frame involves a tandem realignment of two anticodons from pairing with mRNA sequence of the form X XXY YYZ to XXX YYY Z where the spaces indicate... | 1 frameshifting; 39 context effect; Codon anticodon interaction; Escherichia coli ; Recoding; tRNALys; XXXY YYZ frameshift motifs | 2002 |
| 9 |
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Couldwell, William T. | Man for all seasons: W.W. Keen | WILLIAM WILLIAMS KEEN was the catalyst for the advent of neurosurgery in the United States. He served in the Civil War and collaborated with Silas Weir Mitchell in studying injuries sustained to the nervous system. These studies culminated in the publication in 1864 of Gunshot Wounds and Other Inj... | Brain tumor | 2002 |
| 10 |
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Olson, Randall J. | Microphaco update | Microphacoemulsification, or cataract surgery using ultrasound through two small stab incisions. Wound burn is now not a problem with AMO's Sovereign system plus Whitestar technology. | Microphacoemulsification; Wound Burn; Cataract Extraction | 2002 |
| 11 |
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Jones, Bryan W. | Molecular phenotyping of retinal ganglion cells | Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutama... | Aspartic Acid/metabolism; Image Cytometry/methods | 2002 |
| 12 |
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National Medals of Science and Technology Awards (2001) Ceremony and Banquet, held June 13, 2002 | This 51 minutes, 5 seconds video is divided into two parts: the first part is a film introducing the award winners and their achievements; the second is the presentation of the actual awards by George W. Bush, President of the United States. Medal winners were: Mario R. Capecchi for his pioneering... | Molecular genetics; Gene targeting; Transgenic mice; Gene expression; Genetic engineering; Capecchi, Mario R.; Science - Awards - United States; Awards presentations | 2002 | |
| 13 |
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Drews, Frank | Negative priming and stimulus repetition: a reply to Neill and Joordens | Negative priming is reliably obtained with repeated items, but not with novel items. Here, we review why these stimulus repetition effects raise problems for memory based theories of negative priming. Furthermore, we provide empirical evidence casting doubt on Neill and Joordens's (2002) claimthat... | Negative priming; Stimuli; Perception | 2002 |
| 14 |
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Couldwell, William T. | Predictive value of serum prolactin levels measured immediately after transsphenoidal surgery | Object. Prolactin-secreting pituitary adenomas may be managed by surgery, medication, radiotherapy, or observation. The authors reviewed a consecutive series of patients who were followed for at least 5 years after surgery to assess the prognostic significance of preoperative factors (tumor size and... | Prolactin; Transsphenoidal surgery; Pituitary adenoma; Prolactinoma; Transsphenoidal approach | 2002 |
| 15 |
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Kestle, John R. W. | Reduction of transfusion rates in the surgical correction of sagittal synostosis | Object. As public concern about the risks of blood transfusions increased in the mid-1990s, avoidance of transfusions became a goal of surgery for sagittal synostosis. This study was performed to confirm a hypothesized reduction in transfusion rates in recent years and to identify factors associated... | Sagittal synostosis; Sagittal craniosynostosis; Craniectomy; Allogenic blood transfusion; Reduction | 2002 |
| 16 |
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Bernstein, Paul S. | Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models | PURPOSE: To determine the stereochemistry of carotenoids in human ocular tissues in comparison with plasma and liver and to elucidate the possible transformations of dietary (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the eye. Similarly, to characterize the carotenoid profiles in the eye tissues,... | Chromatography, High Pressure Liquid; Stereoisomerism; Xanthophylls | 2002 |
| 17 |
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Kriesel, John D.; Spruance, Spotswood L. | Treatment of herpes simplex labialis. | Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece... | Randomized Controlled Trials; Steroids; Drug Administration Routes | 2002 |
| 18 |
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Couldwell, William T. | Tunneled lumbar drain | The authors report a simple and rapid procedure for tunneling a lumbar drain subcutaneously to facilitate chronic cerebrospinal fluid (CSF) drainage. A standard lumbar puncture (LP) is performed with a large-bore Tuohy needle (14- to 16-gauge), the drainage catheter is advanced into the subarachnoid... | Lumbar drain; Fistula | 2002 |
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