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1 Symons, John DavidCeramide-induced disruption of endothelial nitric oxide synthase dimerization in bovine aortic endothelial cells (BAECs) is not secondary to peroxynitrite formationAn estimated 23.6 million individuals in the United States have diabetes and of those 90-95% have type II diabetes. Cardiovascular complications (e.g., hypertension and vascular dysfunction) are four-fold more prevalent in patients with type II diabetes.1 The mechanism(s) responsible for increased s...2010-01-01
2 Jalili, ThunderCytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in miceWe hypothesized that oxidative stress may contribute to the development of hypertrophy observed in mice with cardiac specific ablation of the insulin sensitive glucose transporter gene (GLUT4, G4H-/-4 ). Measurements of oxidized glutathione (GSSG) in isolated mitochondria and whole heart homogenates...2012-01-01
3 Eisenman, Patricia A.; Symons, John David; White, Andrea T.Eccentric strain at long muscle length evokes the repeated bout effect.The repeated bout effect (RBE) is a phenomenon characterized by less delayed onset muscle soreness (DOMS) and torque deficit after the second of 2 separate eccentric exercise bouts. Previous investigators have reported that shifting of optimum angle after an initial bout of eccentric exercise mediat...Delayed Onset; Muscle Soreness; Popped Sarcomere; Exercise; Optimum Angle2005-11-19
4 Askew, Eldon WEffect of leucine supplementation on fat free mass with prolonged hypoxic exposure during a 13-day trek to Everest Base Camp: A double-blind randomized studyLoss of body weight and fat free mass (FFM) are commonly noted with prolonged exposure to hypobaric hypoxia. Recent evidence suggests protein supplementation, specifically leucine, may potentially attenuate loss of FFM in subcaloric conditions during normoxia. The purpose of this study was to determ...2014-01-01
5 Friedrich, Frances; Walker, James A.Effects of parietal injury on covert orienting of visual attentionThe cognitive act of shifting attention from one place in the visual field to another can be accomplished covertly without muscular changes. The act can be viewed in terms of three internal mental operations: disengagement of attention from its current focus, moving attention to the target, and enga...Dominance, Cerebral; Attention; Extinction, Psychological1984-07
6 Symons, John DavidHyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial functionHigh circulating concentrations of homocysteine (ie, hyperhomocysteinemia [Hhcy]) impair the vascular function of peripheral conduit arteries and arterioles perfusing splanchnic and skeletal muscle regions. The effects of HHcy on coronary resistance vessel function and other indexes of vascular func...Hyperhomocysteinemia; Coronary resistance artery; Arterial stiffness; Arterial permeability; Vascular reactivity; Folate depletion; Rat2002
7 Symons, John DavidInfluence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemiaElevation of plasma total homocysteine (tHcy) is associated with an increased risk of cardiovascular disease, but the underlying mechanisms are not well understood.1 Worldwide, the most common cause of mild hyperhomocysteinemia (HHcy) is deficiency of folate.2,3 Some4-8 but not all9,10 studies sugg...Cystathionine B-synthase; Carotid artery; Aorta; Cardiovascular risk factors; Folate; Hyperhomocysteinemia; Arterial permeability; Arterial stiffness2006
8 Jalili, ThunderMammalian target of rapamycin Is a critical regulator of cardiac hypertrophy in spontaneously hypertensive ratsEvidence exists that protein kinase C and the mammalian target of rapamycin are important regulators of cardiac hypertrophy. We examined the contribution of these signaling kinases to cardiac growth in spontaneously hypertensive rats (SHRs). Systolic blood pressure was increased (P<0.001) at 10 wee...2009
9 Symons, John DavidNa-H exchange inhibition with Cariporide limits functional impairment caused by repetitive ischemiaIntracellular calcium ([Ca]i) overload on reperfusion may be one of the mechanisms responsible for ischemia-induced regional myocardial dysfunction. Because inhibiting the Na-H exchanger (NHE) limits intracellular sodium ([Na]i) and subsequent [Ca]i accumulation, we hypothesized that NHE inhibition ...Reperfusion; intracellular calcium; conscious pigs1998
10 Symons, John David; Jalili, Thunder; Litwin, Sheldon E.Quercetin-supplemented diets lower blood pressure and attenuate cardiac hypertrophy in rats with aortic constrictionQuercetin (Q), a flavonoid found in berries and onions, can reduce blood pressure in hypertensive animals and inhibit signal transduction pathways in vitro that regulate cardiac hypertrophy. We hypothesized that quercetin could prevent cardiovascular complications in rats with abdominal aortic con...2006
11 Jalili, ThunderQuercetin: a treatment for hypertension? - a review of efficacy and mechanismsQuercetin is a polyphenolic flavonoid. Common sources in the diet are apples, onions, berries, and red wine. Epidemiological studies have found an inverse relationship between dietary quercetin intake and cardiovascular disease. This has led to in vitro, in vivo, and clinical research to determine ...2010
12 Symons, John DavidQuercetin: a treatment for hypertension? - a review of efficacy and mechanismsQuercetin is a polyphenolic flavonoid. Common sources in the diet are apples, onions, berries, and red wine. Epidemiological studies have found an inverse relationship between dietary quercetin intake and cardiovascular disease. This has led to in vitro, in vivo, and clinical research to determine ...2010
13 Askew, Eldon W.; Bernstein, Paul S.Serum and macular responses to antioxidant supplementation verus a carotenoid-rich dietary intervention in the elderly.The aim of this study was to observe responses of serum antioxidants, oxidative stress biomarkers, and macular carotenoid pigments to antioxidant supplements or dietary intervention in a single-masked, randomized, pilot clinical study of elderly subjects receiving antioxidant supplements or a dietar...Macula; Serum Carotenoids; Zeaxanthin2006-02-01
14 Metos, Julie MarieTeacher awareness and implementation of food and physical activity policies in Utah Elementary Schools, 2010Introduction Schools are a key venue for childhood obesity prevention policies. The objective of this study was to examine factors associated with elementary school teacher awareness and implementation of their schools' food and physical activity policies. Methods We collected data through an online...2011-01-01
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