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151 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
152 Nau, AdamThe role of heparan sulfate in maintaining stereotyped birdsongSong learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe...Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry2016-04
153 Russell, NicoleThe Role of Introns Within Alpha Conotoxin Genes in Cone SnailsCone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi...2016
154 Du, WantongThe role of mRNA decay in a genetic switchGenes can be switched on or off by regulatory proteins. For example, two genes may each synthesize a protein that downregulates the other gene, creating a repressor- repressor switch that has two stable steady states: one being when the first gene is "on" and the second gene is repressed, and the ot...Messenger RNA - Research; Genetic regulation - Research; Genetic switch; Gene repression; Neural circuitry2016-04
155 Wang, ZhirongThe role of the autism-associated gene kirrel3 in synapse formationAlterations in the gene Kirrel3 are repeatedly associated with intellectual disability and autism. Kirrel3 regulates synapse formation in C. elegans but the role of Kirrel3 in synapse formation in the mammalian brain is unknown. In mice, Kirrel3 is expressed in specific cell types throughout the bra...Autism -- Genetic aspects; Synapses; Kirrel3 gene; Synapse formation2015-04
156 Wheeler, MayaRole of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord InjuryIn humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia...2019
157 Kannan, Sarmishta DiraviamThe Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial SarcomaSarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph...2017
158 Nguyen, NamRoles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial CellsAir pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ...2020
159 Christopherson, AnnaSearch for the highest energy gamma rays of galactic origin using telescope array low energy fluorescence detectorsTelescope Array (TA) is the largest cosmic ray detector in the Northern Hemisphere, designed to measure cosmic rays with energies greater than 1018 eV. TA combines three fluorescence telescope sites, which are each instrumented with 12-14 telescopes, surrounding an array of 507 surface detectors tha...2022
160 Gregersen, DylanSearching for extragalactic stars among candidate halo moving clustersWe seek to identify stars accreted into the Milky Way which are remnants of its merging with smaller galaxies or star clusters. In our approach, we selected stars from candidate moving clusters in the Milky Way's Halo. These stars were grouped by similar stellar characteristics: orbital energy, orbi...Halo stars; Extragalactic origins; Milky Way2012-05
161 Duffin, CalderSequence Activity Relaqtionships in a Radical Sam Peptide MaturaseRibosomally synthesized and post-translationally modified peptide Tte1186a and several point mutation variants are synthesized using solid phase peptide synthesis with FMOC amino acids. Substrate recognition and thioether linkage formation from the radical S-adenosyl methionine Tte1186 maturase is d...2020
162 Hunter, SamuelSignaling Role of the Hamp Domain in the Escherichia Coli Serine ChemoreceptorThe chemoreceptor Tsr enables Escherichia coli to track serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change through other domains of the chemoreceptor molecule to modulate the activity of CheA, a kinase associated with t...Chemoreceptors - Research2016-07
163 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
164 Blair, Coral DeanSnakes as a possible winter reservoir for Western equine encephalitis virusviruses; equine; snakes1964
165 Yang, KevinThe Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in MiceEarlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ...
166 Jensen, Trey W.Spectral evolution in high redshift quasars from the final boss sampleWe report on a study of the spectral variations in a sample of 102,150 quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) of the Sloan Digital Sky Survey (SDSS-III). After mitigating selection effects and Malmquist bias over the redshift range 2:1 □ z □ 3:5, we create high...Quasars -- Spectra; Red shift -- Observations; Baryon Oscillation Spectroscopic Survey; Sloan Digital Sky Survey; Redshift evolution
167 Auduong, PriscillaSpinal muscular atrophy modeled in drosophila melanogasterSpinal Muscular Atrophy (SMA) is the most commonly inherited cause of death in children (Park, Kariya, & Monani, 2010 for review). This disease is characterized by a loss of motor neurons which leads to muscle degeneration, paralysis, and eventual death by respiratory failure (Monani, 2005 for revie...Spinal muscular atrophy - Research; Drosophila melanogaster - Researcher2012-05
168 Thompson, LaurenSptlC2 Deletion in Endothelial Cells: Implications for Arterial FunctionUsing pharmacological and genetic approaches to inhibit whole-body ceramide biosynthesis, our laboratory showed that this sphingolipid contributes importantly to hypertension and vascular dysfunction associated with diet-induced obesity in mice. Here we tested the hypothesis that inducible, endothel...2020
169 Thomas, J PaytonStability of genetic oscillators with distributed delayed feedbackGenetic oscillators govern periodic phenomena in biology including circadian rhythms and are also the basis of biological clocks used in the design of synthetic genetic circuits. Models of genetic oscillators tend to neglect biological detail, however, because biological systems tend to be too compl...2023
170 Wainer, TobinStar clusters in the triangulum galaxy: star cluster catalog and mass function fittingWe construct a catalog of star clusters in the Triangulum Galaxy (M33). The catalog is the result of the Local Group Cluster Search (LGCS) citizen science project through Zooniverse, where users classify images from the Hubble Space Telescope (HST). We base our star cluster catalog on the fraction o...2021
171 Hahm, SuhyunStressors of varying properties induce differences in the modulation of behavior and biologyStress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor...2022
172 Skedros, Gregory AthanasiosStructural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraintBones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending...Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny2015-08
173 Farrall, NicholasStructural characterization of the full-length exocyst complex by transmission electron cryo-microscopyThe exocyst is a conserved octameric protein complex in eukaryotes that is essential for tethering and fusion of vesicles to the plasma membrane. Composed of eight subunits, it is essential for growth, secretion, and developmental processes and has been implicated in cell motility, autophagy, cell d...Saccaromyces cerevisaie - Cytology; Cryomiscroscopy - Research2014-05
174 Dyer, JamieStudies of Spectral Variability of Quasars with Multi-Epoch AnalysesQuasars are supermassive black holes known to drive galaxy formation. They can have masses up to 109 solar masses and are the most luminous known objects in the sky, making them very important trackers of cosmic evolution. Given the large amount of research already surrounding quasar astrophysics, t...2017
175 Bull, August JohnStudying Galois Representations Using Elliptic CurvesDiophantine equations and their solution sets are prominent subjects of study in number theory. These equations are often studied modulo prime numbers or prime ideals in field extensions. Galois Theory is well-suited to study field extensions, but Galois groups are often mysterious. To remedy this, ...2020
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