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Creator | Title | Description | Subject | Date |
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Sperber, Alexander M. | A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cells | Heart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I... | | 2022 |
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Calder, Dallen | Adipocyte enhancer binding protein 1 (AEBP1) as a potential therapeutic target to combat cardiac fibrosis | Fibrosis is one of the major hallmarks of heart failure (HF) progression and is characterized by fibroblast activation and excess extracellular matrix (EMC) deposition. RNA sequencing of myocardial tissue acquired from HF patients showed a significant upregulation of adipocyte enhancer binding prote... | | 2022 |
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Isom, Anika | Amniotic fluid treatment of vocal fold injury in an in vivo rabbit model | Hyaluronic acid (HA) injectables are a standard treatment for vocal fold injuries in both clinical and research settings. Results from these treatments are not permanent, however, and may vary in effectiveness. Because of this, there is a significant clinical interest in finding an alternative for H... | Vocal folds; rheology; wound healing of vocal folds; hyaluronic acid; amniotic fluid; regenerative medicine | 2022 |
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Mallender, Zachary | Assay of the dreem device on sleep metrics and an exploration of sleep staging in chronic short sleepers during time in bed extension | Despite clear and plentiful research that sleeping less than seven hours per night has a wide array of health consequences, a large portion of American adults report sleeping less than seven hours per night and thus receive chronic insufficient sleep. Many studies exploring the consequences of insuf... | | 2022 |
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Tazehabadi, Tara | Bioinformatics to detect functional interactions important for the DNA repair enzyme mutyh | DNA is the blueprint of all biological life as it provides the means necessary for sharing of genetic information. DNA is formed and stabilized by interactions between four unique bases, Adenine (A), Cytosine (C), Guanine (G), and Thymine (T) which come together in predetermined patterns to create a... | | 2022 |
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Furrer, Summer | Cellular and subcellular localization patterns of hepatitis delta virus in sjogren's syndrome salivary gland tissue | Primary Sjogren's syndrome (pSS) is an autoimmune disorder, predominantly affecting women, that causes dry eyes, dry mouth, fatigue, and other extraglandular manifestations (Le Goff et al., 2017). It has been shown that chronic pathogen exposure can lead to development of autoimmune diseases such as... | | 2022 |
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Andersen, Kara | Cervical dorsal root ganglion imaging for studying neuronal nocicieptive ciruit changes in migranine models | Migraine neuroscience is a field in its infancy, with migraine being a remarkably common yet poorly understood sensory circuit disorder. It is characterized by attacks of unilateral, throbbing craniofacial pain, with sensitivity to movement, visual, auditory, and other afferent inputs. Migraines can... | | 2022 |
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Jensen, Madeline | Changes in microbial diversity in storm-water green infrastructure | Increased urbanization has led to excess nutrients in urban ecosystems. Stormwater Green Infrastructure (SGI) is a method to capture these nutrients and prevent runoff. However, an increased understanding of ecosystem processes is needed to create more efficient SGIs. Past studies have shown that pl... | | 2022 |
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Young, Chelsea | Effect of docosahexaenoic acid on female rat pups after controlled cortical impact | Pediatric traumatic brain injury (TBI) is a leading cause of death and disability in children. After an initial mechanical impact, the injury continues to evolve and propagate in a secondary injury cascade. Previous research by the Schober lab has indicated that docosahexaenoic acid (DHA) is a promi... | | 2022 |
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Kasera, Shalini | Effect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the rat | Intrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �... | | 2022 |
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Thomas, Nathaniel | The HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3 | During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of... | | 2022 |
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Lan, Yung-Chi | HYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathway | Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an... | | 2022 |
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Watson, Andre | Patterns of parasitism in a common Utah Rodent | Male-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi... | | 2022 |
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Lawrence, Derek John | Porous fluorapatite and hydroxyapatite scaffolding with human osteoblast cells bone graft: a pilot study | The incidence of bone injuries and defects in the United States has continued to increase in recent years, prompting the need for surgical interventions to repair them [1]. Currently in use are several interventions, autografts, allografts, and manufactured apatites, each with their own benefits and... | United States; fluorapatite; temperatures | 2022 |
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Lee, Hani | Post-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatment | Post-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ... | | 2022 |
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Excell, Katerina | The role of amyloid precursor protein in a model of alzheimer's disease | Alzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ... | | 2022 |
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Peterson, Mikal | Somatic chromosome pairing in interspecific drosophila hybrid and hybried rescue crosses | Homologous chromosomes of somatic tissue pair together in Drosophila. One current model proposes that somatic pairing starts in an undirected manner; when sites on the chromosome, called "buttons", come into contact and pair. Then, after this initial pairing, the rest of the chromosome then synapses... | | 2022 |
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Olivia Hanson | Spinal cord injury-induced neuropathic pain & the gut microbiome: a review | Most spinal cord injuries (SCI) result in spinal cord injury-induced neuropathic pain (SCINP). SCI-NP is a major healthcare concern given the extensive burden it places on both patients and the healthcare system. This, coupled with the lack of effective and available treatments for those suffering f... | | 2022 |
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Hahm, Suhyun | Stressors of varying properties induce differences in the modulation of behavior and biology | Stress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor... | | 2022 |
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Domagala, Drue | Synthesis of protacs to inhibit toll-like receptors | The immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig... | | 2022 |