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CreatorTitleDescriptionSubjectDate
326 Sekercioglu, CaganKeystone species in seed dispersal networks are mainly determined by dietary specializationOne central issue in Ecology ecology has been the definition and identification of keystone species, i.e., species that are relatively more important than others for maintaining the structure of a community. Several keystone species concepts have been proposed, and network theory has been pointed o...2014-01-01
327 Beckerle, Mary C.Kindler syndrome protein is regulated by Transforming Growth Factor-β and involved in integrin-mediated adhesionTransforming growth factor-β1 (TGF-β1) contributes to tumor invasion and cancer progression by increasing the motility of tumor cells. To identify genes involved in TGF-β-mediated cell migration, the transcriptional profiles of human mammary epithelial cells (HMEC) treated with TGF-β were compar...Kindler syndrome; Kindlerin; Talin; Focal adhesions; FERM domain2004
328 Dale, ColinKinetics of maturation of trypanosome infections in tsetseEstimates of the time delay between the infective bloodmeal and maturation (incubation or maturation time) for 4 trypanosome stocks (2 Trypanozoon and 2 Trypanosoma congolense) show that maturation time in tsetse is not a parasite species-specific constant. The mean incubation time of a Trypanosoma ...1995
329 KSL News clip of Mario Capecchi receiving the National Medal of Science for 1991This 1 minute, 44 seconds news clip from Salt Lake City's KSLTV, Channel 5 shows Mario Capecchi receiving the National Medal of Science for 1991 from President George W. Bush at the June 13, 2002 awards ceremony. The medal was presented for Capecchi's work in genetics and his development of the pro...Transgenic mice; Gene targeting; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news1992-06
330 KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997This 3 minutes, 1 second video clip from Salt Lake City's KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases.Gene targeting; Genetic engineering; Molecular genetics; Cancer Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Television feature stories1997-11-09
331 Capecchi, Mario R.Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient miceWhile nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin level...2000
332 Capecchi, Mario R.Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient miceWhile nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels...ACE2000-10-31
333 Sekercioglu, CaganLandscape constraints on functional diversity of birds and insects in tropical agroecosystemsIn this paper, we analyze databases on bird and insects to assess patterns of functional diversity in human-dominated landscapes in the tropics. Perspective from developed landscapes is essential for understanding remnant natural ecosystems, because most species experience their surroundings at spat...2008-01-01
334 Goller, FranzLateralization as a symmetry breaking process in birdsongThe singing by songbirds is a most convincing example in the animal kingdom of functional lateralization of the brain, a feature usually associated with human language. Lateralization is expressed as one or both of the bird's sound sources being active during the vocalization. Normal songs require ...Lateralization; Syringeal muscles; Respiration; Gating2007-03
335 Capecchi, Mario R.Lessons from angiotensin-converting enzyme-deficient miceSince the first description of renin by Tigerstedt and Bergman [1] in 1898, many papers have described the biochemistry and physiological roles of the reninangiotensin system [2]. A critical component of this system is angiotensin-converting enzyme (ACE), a peptidase which cleaves the inactive pep...1996
336 Capecchi, Mario R.Lessons from angiotensin-converting enzyme-deficient mice.Mice which lack ACE have low systolic blood pressure, reduced male fertility and a renal abnormality characterized by medullary hypoplasia and the inability to concentrate urine. The diverse phenotypes caused by inactivation of a single gene emphasize the many functional roles of ACE and the renin-q...Blood Pressure; Cell Line;Fertility; Kidney; Testis1991-11-01
337 Beckerle, Mary C.LIM domain-containing protein Trip6 can act as a coactivator for the v-Rel transcription factorThe retroviral oncoprotein v-Rel is a transcriptional activator in the Rel/NF-KB family of eukaryotic transcription factors. v-Rel malignantly transforms a variety of cell types in vitro and in vivo, and its transforming activity is dependent on the ability of v-Rel to bind to DNA and activate trans...LIM domains; Oncoproteins; v-Rel; Retroviral oncogene; Trip6; Coactivator; Malignant transformation; NF-kB; Two-hybrid assay1999
338 Beckerle, Mary C.LIM proteins in actin cytoskeleton mechanoresponseThe actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration. Stress fibers are contractile, actomyosin structures that physically couple to the extracellular matrix through ...2014-01-01
339 Shapiro, Michael D.Limb diversity and digit reduction in reptilian evolutionThe study of morphological rules, or trends, offered classical biologists the opportunity to address the mechanisms underlying the evolution of anatomical designs. Regularities in evolution suggested that common functional or developmental rules governed the transformation of structures. Parallelism...Digit loss; Morphology; Adaptation2006
340 Local television news clips for June 14, 1994 featuring Mario CapecchiThis is a compilation of news clips from Salt Lake City's four major commercial television stations (Channels 2, 4, 5, and 13) lasting a total of 2 minutes, 59 seconds. The topic is Capecchi's winning of the General Motors Corporation's Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contrib...Transgenic mice; Gene targeting; Cancer - Research - Awards; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news1994-06-14
341 Olivera, Baldomero M.; ; McIntosh, J. MichaelLocalization of [125I] ω-conotoxin GVIA binding in human hippocampus and cerebellumTHE peptide toxin ω-conotoxin GVIA (ω-CgTx) has been shown to be a high affinity ligand for N-type calcium channels in the brain. We have employed [125I]ω-CgTx to localize N-type channels in human hippocampus and cerebellum using autoradiography. Ten micron thick slidemounted tissue sections of...Conotoxins; Peptide toxins1993
342 Capecchi, Mario R.Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and...Animals; Base Sequence; Genes, Viral; Plasmids; Thymidine Kinase1983-07-01
343 Thomas, Kirk R.; Capecchi, Mario R.Location of crossovers during gene targeting with insertion and replacement vectors.Gene targeting was used to introduce nonselectable genetic changes into chromosomal loci in mouse embryo-derived stem cells. The nonselectable markers were linked to a selectable marker in both insertion- and replacement-type vectors, and the transfer of the two elements to the Hprt locus was assaye...Genetic Vectors; Molecular Sequence Data; Restriction Mapping1993-04
344 Adler, Frederick R.Long-term models of oxidative stress and mitochondrial damage in insulin resistance progressionInsulin resistance, characterized by a reduced cellular response to insulin, is a major factor in type 2 diabetes pathogenesis, with a complex etiology consisting of a combination of environmental and genetic factors. Oxidative stress, which develops through an accumulation of toxic reactive oxygen ...2014-01-01
345 Bastiani, MichaelLoss of axons in the cat optic nerve following fetal unilateral enucleation: an electron microscopic analysisBetween the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population of the E-48 nerve was estimated to be 328,000. In contrast, estimates from two normal adults were 159,...Ganglion cell death; Retinofugal projection; Retinal ganglion cell axons1983
346 Goller, FranzLow-dimensional dynamical model for the diversity of pressure patterns used in canary songDuring song production, oscine birds produce large air sac pressure pulses. During those pulses, energy is transferred to labia located at the juncture between the bronchii and the trachea, inducing the high frequency labial oscillations which are responsible for airflow modulations, i.e., the utt...Serinus canarias; Air sac pressure2009-04
347 Adler, Frederick R.; Liou, Theodore G.; Cahill, Barbara C.Lung transplantation and survival in children with cystic fibrosisThe effects of lung transplantation on the survival and quality of life in children with cystic fibrosis are uncertain. We used data from the U.S. Cystic Fibrosis Foundation Patient Registry and from the Organ Procurement and Transplantation Network to identify children with cystic fibrosis who were...Life; Infection; Risk; Harm2007
348 Linton, Matthew J.Magnitude and mechanisms of disequilibrium between predawn plant and soil water potentialsPredawn plant water potential (Uw, measured with leaf psychrometers) and surrogate measurements made with the pressure chamber (termed Upc here) are used to infer comparative ecological performance, based on the expectation that these plant potentials reflect the wettest soil Uw accessed by roots. T...Roots; Transpiration; Solutes2003
349 Adler, Frederick R.; Feener, Donald H.Maintaining diversity in an ant community: modeling, extending, and testing the dominance-discovery trade-offAnt communities often consist of many species with apparently similar niches. We present a mathematical model of the dominance-discovery trade-off, the trade-off between the abilities to find and to control resources, showing that it can in principle facilitate the coexistence of large numbers of s...Coexistence; Dominant species; Parasitoid2007
350 Thomas, Kirk R.; Capecchi, Mario R.Maintenance of functional equivalence during paralogous Hox gene evolution.Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp...Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice2000-02-10
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