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| Creator | Title | Description | Subject | Date | ||
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Jorgensen, Erik | UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles | The unc-11 gene of Caenorhabditis elegans encodes multiple isoforms of a protein homologous to the mammalian brain-specific clathrin-adaptor protein AP180. The UNC-11 protein is expressed at high levels in the nervous system and at lower levels in other tissues. In neurons, UNC-11 is enriched at pr... | Caenorhabditis elegans; Synaptic vesicles; unc-11; Synaptobrevin; Endocytosis | 1999 |
| 2 |
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Jorgensen, Erik | μ2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans | Synaptic vesicles must be recycled to sustain neurotransmission, in large part via clathrin-mediated endocytosis. Clathrin is recruited to endocytic sites on the plasma membrane by the AP2 adaptor complex. The medium subunit (u 2) of AP2 binds to cargo proteins and phosphatidylinositol-4,5-bisph... | Synaptic vesicles; Caenorhabditis elegans; Adaptin | 2008 |
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