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Creator | Title | Description | Subject | Date |
51 |
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Gardner, Shalyce | Functional test for possible genetic modififers of piga defficiency | PIGA deficiency is a rare X-linked recessive disorder that lacks effective treatment options. A protein encoded by the PIGA gene catalyzed the first step in biosynthesis of Glycosylphatidylinositol (GPI) anchors. Partial loss of function mutations in PIGA can prevent a cell from being able to synthe... | | 2023 |
52 |
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Borrowman, William | Gas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common garden | The majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ... | Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah) | 2014-04 |
53 |
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Loret, Amy | Genetic Modifiers of Severity in Collagen VI-Related Muscular Dystrophy | Collagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a... | | 2019 |
54 |
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Rahmati, Kasra | Genetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia Coli | Bacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW... | | 2020 |
55 |
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Acosta, Lehi | Genotype-dependent susceptibility to influenza and titer-virulence discordance | The influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ... | Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin | 2016-05 |
56 |
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Kutschke, Michael | Hip joint center differences between dual fluoroscopy, functional hip, and coda - establishing a reference standard | Measurements of joint angles, moments, and forces may be highly sensitive to positional changes in the center of a joint. Due to its deep location, the human hip joint center (HJC) can be difficult to determine. Previous studies have defined the HJC relative to external landmarks using infrared moti... | Hip joint; Hip joint center | 2015-05 |
57 |
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Thomas, Nathaniel | The HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3 | During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of... | | 2022 |
58 |
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Lan, Yung-Chi | HYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathway | Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an... | | 2022 |
59 |
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Weaver, Bradley | Hypoxia and the mesenchymal transition in glioma | Recent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum... | Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition | 2014-04 |
60 |
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Fackler, Anderson N. | Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegans | Neurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a... | | 2018 |
61 |
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Johnson, KariAnne Rencher | Identification of PASK substrates and/or interacting proteins | PAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live... | Biology | 2012-05 |
62 |
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| Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICU | The University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye... | | 2023 |
63 |
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Ong, Elaine | Identifying Natural Genetic Modifiers of Apoptosis and Retinal Degeneration | Apoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ... | | 2018 |
64 |
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Au, Alexander | Impact of population density of left atrial remodeling in patients with atrial fibrillation | Atrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow... | Atrial fibrillation Treatment | 2012-05 |
65 |
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Pearson, Cassidy | Major Urinary Protiens as a signal of genetic Quality and Infection status | The Hamilton-Zuk hypothesis suggests that susceptibility to infectious disease is so important that many physical traits, particularly secondary sexual characters, will evolve to signal genetic quality for resistance to prospective mates. We expanded upon this theory using the house mouse (Mus muscu... | | 2018 |
66 |
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Shimko, Tyler | Mapping suppressors of premature sperm activation in C. Elegans | The sperm of the roundworm Caenorhabditis elegans move by a crawling motion, in contrast to mammalian sperm, which exhibit a swimming motion. This method of locomotion makes the sperm of C. elegans an excellent model for examining cell motility. In order to become motile, the sperm must undergo the ... | Caenorhabditis elegans -- Spermatozoa; Sperm activation | 2015-05 |
67 |
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Guernsey, Michael | Mclr is not solely responsible for pigmentation variation among domestic pigeons | Feather pigmentation in the domesticated rock pigeon, Columba livia, is stunningly diverse. Plumage pigmentation in this, and other, columbid (pigeon and dove) species plays an important role in mate choice and thus is a driving factor in the process of sexual selection. To study the genetic basis o... | | 2012 |
68 |
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Green, Austin | Measuring occupancy and occurrence of medium and large mammals in Red Butte Canyon Research Natural Area using motion-activated camera traps | With expanding urbanization and development, human encroachment on wilderness areas continues to increase. In Utah, much of the once pristine and untouched mountain ecosystems of the Wasatch Front have been developed for recreation and other human use, and this increasing human-wildlife interaction... | Red Butte Canyon (Salt Lake County, Utah); Wilderness area monitoring - United States; Wildlife conservation - Utah | |
69 |
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Astin, Holly M. | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | | | 2016 |
70 |
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Astin, M. Holly | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | The liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis... | Liver X receptors - Research; Zebrafish - genetics | 2016-08 |
71 |
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Alexander, Amanda | Parental conflict with adult children | Parental conflict with adult children is something that is well known anecdotally, but has rarely been studied in light of other, more serious conflicts between parents and their children. However, parental conflict with adult children (adult being defined as between the ages of 18 and 25) is someth... | Adult children - Family relationships; Adult children - Psychology | 2012-05 |
72 |
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Watson, Andre | Patterns of parasitism in a common Utah Rodent | Male-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi... | | 2022 |
73 |
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Radhakrishnan, Parvathi | PI3K inhibitors as potential new therapy against breast cancer progression | Receptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso... | Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research | 2014-05 |
74 |
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Lee, Hani | Post-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatment | Post-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ... | | 2022 |
75 |
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Peterson, John | Potential Therapeutic Inhibition of Epigenetic Modulator LSDI in Glioblastoma Multiforme | Glioblastoma (GBM) is the most common primary brain tumor in adults, and while advances in surgery, radiation, and standard chemotherapies have improved survival in this disease marginally over the years, the outcomes for most patients remain disappointing (Bhat, 2013). Recent studies have identifie... | | |