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| Creator | Title | Description | Subject | Date | ||
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Coffin, Cheryl M.; Capecchi, Mario R. | Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. | Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has... | Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors | 2004-11-01 |
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Capecchi, Mario R. | Housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. | Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism occurring in most cell types. However, this housekeeping gene is expressed at very high levels in a number of mammalian tissues including the lactating mammary epithelium, suggesting additional roles for XOR in these tiss... | Body Weight; Cell Differentiation; Cell Membrane; Epithelium | 2002-12-15 |
| 3 |
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Capecchi, Mario R. | In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. | Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a prerequisite for the analysis of the potent... | Animals; Cell Differentiation; Cells, Cultured; Gene Transfer Techniques; Mice, Transgenic | 2005-10-23 |
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Mansour, Suzanne L.; Thomas, Kirk R.; Capecchi, Mario R. | Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. | We demonstrate that the frequency of gene targeting is unaffected by the length of nonhomologous DNA transferred to a target chromosomal sequence. A result of this finding is that a much wider spectrum of designed genomic alterations is now feasible. As a first application, we inserted a 5.4-kilobas... | Blotting, Southern; Cell Differentiation; Fluorescent Antibody Technique; Restriction Mapping | 1990-10 |
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