Filters: Department: "Neurobiology & Anatomy" School Or College: "School of Medicine" Collection: "ir_uspace" Subject: "Animals"
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| Creator | Title | Description | Subject | Date | ||
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Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R. | Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. | Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00... | Animals; Clone Cells; Restriction Mapping; Stem Cells | 1988-11-24 |
| 2 |
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Moon, Ann M.; Capecchi, Mario R. | Fgf8 is required for outgrowth and patterning of the limbs. | The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep... | Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm | 2000-12-26 |
| 3 |
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Moon, Ann M.; Capecchi, Mario R. | Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. | Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in... | Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators | 2004-09 |
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