Honors Theses Open Access
 
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1 Godfrey, RoseA porcine model for the development and testing of preoperative skin preparationsClinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu...2022
2 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma; genetics; research; metastasis; genetics; research; biochemistry; genetics2015-12
3 Arnoholt, AlaynaAn analysis on the influence of anxiety in post error slowingAnxiety disorders are among the most common mental disorders and affect 15.7 million Americans each year (Lépine, 2002, p. 4). Anxiety is associated with reduced productivity, physical distress, and other diseases such as depression. Anxiety could also be influential in error response (Compton et a...Americans2021
4 Cummins, HeatherAnalysis of eyes shut (EYS) function during intestinal regeneration in drosophila melanogasterThe intestine is a self-renewing organ under constant stress. It is the first line of defense against toxins and bacteria and enables digestion and nutrient absorption. Its homeostasis (controlled regulation) plays a critical role in the maintenance of organ function and prevention of tumor generati...diseases or cancers; homeostasis; sufficient2019
5 Zhu, JudyAnalysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoinOxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d...Oxidation; guanine oxidation products; 5-guanidinohydantoin; iminoallantoin; equilibrium relationship2015-05
6 Edwards, Jennifer LynnApplication of a TBHP-mediated Wacker-type oxidation to internal alkenesThe Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ...Wacker-type oxidatioin; research; TBHP2013-05
7 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids; biotechnology2013-08
8 Burga, Carlos AlbertoBinary superlattices of semiconductor nanocrystals : a path towards possible high-temperature superconductivityThis thesis provides a platform to experimentally test Dr. Daniel Mattis' theoretical work on the possible superconductive behavior of nanostructured intrinsic semiconductors1-2. The theoretical work hinged on the nano-scale architecture of semiconductors. Therefore, using various types of semicondu...Semiconductor nanocrystals; Superconductivity; Superlattices as materials2013-05
9 Rose, StevenBiofuel cells for self powered arsenic detectionResearch in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi...Fuel cells; Arsenic - Detection2013-05
10 Galinat, ShelbyBipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteriesEnergy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a...2022
11 Simonsen, KyleBreast cancer knowledge and attitudes among women in ArmeniaBackground: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a...Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic)2013-07
12 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
13 Nicolo, TeraCharacterization of mitochondria-modified electrodesIn order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces...Electrodes; Herbicides - Detection2013-05
14 Odendahl, NathanComparison of popular force fields for molecular modeling of proteins applied to ice binding of the tenebrio molitor antifreeze proteinIce Binding Proteins (IBPs) are a class of proteins that affect the melting and freezing temperatures of ice. While substantial research has been conducted to understand the properties of IBPs, experimental and molecular dynamics simulations have not satisfactorily explained the mechanism of the i...Antifreeze proteins - Research; Ice binding proteins; Tenebrio molitor; Antifreeze protein; Force fields2016-04
15 Besic, ArnelCreation and characterization of organic mixed conductorsOrganic mixed ionic electronic conductors (OMIECs) are conjugated polymers that conduct both ions and electrons. These materials are promising for applications in healthcare and energy technologies, including biosensors and batteries. An obstacle for using these materials in next-generation technolo...2024
16 Peterson, Joseph RyanDeflagration and detonation modeling of heterogeneous condensed phase explosivesA modeling approach to the deflagration and detonation phenomena is employed to study a variety of explosive scenarios. An engineering model for macroscale reaction of energetic materials over the wide range of explosive reaction from deflagration to detonation is developed based upon solid foundati...Deflagration phenomena; Detonation phenomena; mesoscale model2012-05
17 Lim, Koun (Kasha)Deglycoyslation of glucose oxidase and its application within high power enzymatic fuel cellsTo compensate for the increase of carbon dioxide level and the energy exhaust, an enzymatic fuel cell (EFC) has been investigated by researchers. In the paper, a chemical oxidative deglycosylation of an enzyme was investigated to furture improve EFCs. By deglycosylating an enzyme, the distance betwe...Fuel cells - Research; Electric power - Research; Deglycosylation; Enzymatic fuel cell; Glucose oxidase2016-04
18 Munn, JacksonDetermining microbial community composition and methane flux or red butte canyon sediment over timeMethane is a potent greenhouse gas that is released from the soil into the atmosphere, which contributes heavily to global warming. One potential way of reducing the amount of methane in the air is through studying methane consuming bacteria (methanotrophs) and how they interact with other microbes ...2022
19 Sanders, SaraDevelopment of a novel, coumarin-europium sensor for reactive oxidizing speciesThe synthetic framework has been developed for two fluorescent probes of Reactive Oxidizing Species (RoxS) based on a coumarin-europium fluorescence pair. The coumarin moiety's selectivity for hydrogen peroxide coupled with 620 nm shifted emission of the europium will make these novel sensors biolog...Reactive Oxygen Species - analysis2012-05
20 Lutz, KevinDiscovery of platinum (II) cocrystals with highly fluorinated cyanocarbonsThis thesis investigates new platinum(II) complex cocrystals with highly fluorinated cyanoaromatics. While π stacking compounds of polycyclic aromatic hydrocarbons and cyanoaromatics have been reported, interactions with transition metal complexes have yet to be explored. Crystal structures for (pp...2023
21 Kent, AlexandraDNA split aptamers as a biosensing platform for the detection of small drug moleculesPrescription drug overdose and abuse is a leading cause of death in the United States. It is a serious issue and has become increasingly problematic as opioids are being prescribed with a higher frequency. For this reason, fast, accurate detection of small drug molecules is crucial. The current stan...Drug testing; Biosensors; DNA split aptamers
22 Kim, Alexander H.DPP Signal Regulation Through O-Linked GlycosylationDorsal closure in Drosophila is an embryogenic event that involves coordinated cellular shape changes. A series of interconnected signaling cascades are utilized to accomplish this task, one of which is the Decapentaplegic (Dpp) pathway. Dpp is a member of the TFG-β family of secreted cytokines, wh...2017
23 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...Physicians; University of Utah Hospital's; antibiotics2019
24 Bischoff, AmandaElucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate OxidatiinThe Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s...2016
25 Cocke, Rebecca C.Evaluating the Catalytic Activity of Iron and Nickel Impurities in Bare High-Pressure High-Temperature NanodiamondMany metal nanoparticles are used as catalysts for various reactions and are held on supports. High-Pressure High-Temperature nanodiamonds (HPHT ND) are able to support metal nanoparticles even under strenuous chemical environments due to their robust nature. The production of HPHT ND includes the u...2018
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