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Filters: Department: "Biomedical Engineering" Format: "application/pdf" School Or College: "College of Engineering" Collection: "ir_htoa"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 26 |
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Koblanski, Kasper | Liver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilization | Insulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin... | 2022 | |
| 27 |
 |
Citterman, Abigail R. | Low frequencies improve intensity discrimination for electrocutaneous artificial sensory feedback | The current standard of care for those living with upper-limb loss is unsatisfactory, with up to 50% of amputees abandoning their prostheses, citing unintuitive use and a lack of sensory feedback as critical factors. Electrocutaneous stimulation uses electrodes on the skin to evoke tactile sensation... | 2022 | |
| 28 |
 |
Harding, Anna Neibling | Low-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor Intent | Surface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du... | 2019 | |
| 29 |
 |
Armstrong, Blair P. | Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphoma | Non-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF... | 2021 | |
| 30 |
 |
Wang, Minna | Managing limited ECG access in a clinical cardiac electrophysiology setting | Electrocardiographic Imaging (ECGI) is a computational approach that seeks to reconstruct cardiac electrical activity with high precision from body surface ECGs by solving a numerical inverse problem. Though there have been great advancements in ECGI, there is still a need for progress in specific a... | Electrocardiography - Research; Heart - Diseases - Diagnosis; Body surface potentials | 2016-05 |
| 31 |
 |
Kodele, Christian | Multivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma Cells | Non-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon... | 2018 | |
| 32 |
 |
Khoury, Mark | Muscle activity changes due to immobilization and partial weight bearing of the lower leg | Tibial fractures account for half a million hospitalizations per year. Although clinical treatment of tibial fractures requires immobilization of the affected limb and partial weight bearing (PWB) prescriptions, the effects of this treatment protocol on gait and muscle activity have not been studied... | Muscles -- Physiology; Tibia -- Wounds and injuries; Muscle activity; Partial weight bearing | 2015-05 |
| 33 |
 |
Richards, Grace | My lung health: shared decision making for lung cancer screening | Lung cancer is the deadliest cancer in the United States. In 2019, around 140,000 deaths occurred in the Untied States due to lung cancer. Low-dose CT screening to detect lung cancer is an effective tool for preventing these deaths, but the screening has some harms associated with it in addition to ... | 2023 | |
| 34 |
 |
Tripathy, Anurag | Nickel-Functionalized Solid-State Titania Nanotube Array for the Electrochemical Detection of Breath-Based Biomarkers in Colorectal Cancer | Colorectal cancer (CRC) is the second most common cancer in the United States with approximately 137,000 new cases each year, 50,000 of which are fatal due to belated screenings [1]. The gold-standard detection method is colonoscopy, a direct visualization tool that facilitates the removal of minor ... | 2019 | |
| 35 |
 |
Stewart, Caden | Paternal diet modulates naturalistic foraging in mice and interacts with cacna1c genetic effects to shape decision sequences | Some of the largest challenges facing the healthcare system stem from the dual epidemics of obesity and mental disorders. Obesity can alter an organism's epigenetics, and these changes may be passed on to offspring, which in turn may alter mental health. The purpose of this study is to investigate t... | 2022 | |
| 36 |
 |
Adams, Isabel | Pelvic floor acceleration is damped compared to skeletal acceleration while walking | One in four American women suffer from pelvic floor disorders (PFDs) [1]. Current research shows the cause of pelvic organ prolapse is multifactorial, with risk factors including vaginal childbirth and advancing age [2]. To facilitate the development of prevention strategies and treatments to minimi... | 2023 | |
| 37 |
 |
Schlegel, Isabelle B. | Peptide-fab conjugates to improve treatment of neovascular age-related macular degeneration | Age-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat... | 2021 | |
| 38 |
 |
Frederiksen, Hunter | Pharmacokinetics of Locally Delivered Vancomycin as a Powder & in a Hydrogel | Orthopedic surgeons currently administer powder vancomycin directly over surgical sites in order to mitigate infections. Local antibiotic administration has been effective at reducing infections; however, there have been few preliminary studies investigating the pharmacokinetics of locally delivered... | 2018 | |
| 39 |
 |
Singh, Anand | Polyurethane molecular weight determination in catheters via gel permeation chromatography | Antimicrobial catheter extrusions are loaded with an antiseptic drug in order to help prevent catheter-related infections. Previous research has shown that polymer molecular weight (Mw) can be used to control drug loading levels. Polyurethane based resin and catheter shaft extrusion samples were cho... | Catheters - Research; Bacterial diseases - Prevention; Drug loading levels; Gel permeation chromatography; Diffusion distance; Antimicrobial catheter extrustions; Catheter shaft extrusions; Bacterial Infections; MATLAB | 2016-05 |
| 40 |
 |
Uchida, Kimberly Akimi | Post-translational regulation of the tumor suppressor PDCD4 | Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the... | Tumor suppressor proteins - Regulation | 2013-12 |
| 41 |
 |
Lietzke, Stephanie | Removal of endotoxins from recombinant antithrombin | Endotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr... | Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis | 2016-04 |
| 42 |
 |
Marler, Tyler | The role of gangliar plexi in the treatment of atrial fibrillation | Introduction: Gangliar plexi (GP) are bundles of interconnected neurons found embedded in FPs (FPs) surrounding the atria of the heart. The function of these neurons is controversial but they may form a localized control system for the heart and play a role in the induction of atrial fibrillation (A... | Atrial fibrillation Treatment; Gangliar plexi | 2012-05 |
| 43 |
 |
Novy, Jenna | Selective and Localized Marking of Activated Dendritic Spines Using a Novel Genetic Construct, Slayr | The brain's ability to store memory is as remarkable as it is complex. The mechanism behind memory storage is still not fully understood and has become an essential question in the neuroscience field. Long-term memories are thought to form via the strengthening of specific connections between neuron... | 2020 | |
| 44 |
 |
Newton, James | Social behaviors in the developing Danio Rerio larva and adult Danionella | Larval zebrafish (Danio rerio) in most respects excel as an animal model in the study of neural networks, due to their small size and optical transparency. These traits permit optogenetic manipulation and live neuronal imaging of the entire brain, which when paired with behavioral analysis, have pot... | Zebrafish (Zebra danio) - behavior; Zebrafish - embryology; Zebrafish - physiology | 2016-04 |
| 45 |
 |
Javdan, Shwan | Targeted HPMA copolymer-gemcitabine conjugates for the treatment of ovarian carcinoma | Each year in the United States, over 14,000 women die from ovarian cancer. Anthracyclines-a class of chemotherapeutics-have long been the primary treatment for this and many other cancers, yet they often leave patients with cardiotoxicity, hepatotoxicity, and a number of other adverse effects. Polym... | Ovaries -- Cancer -- Treatment; Polymeric drug delivery systems; Polymer-drug conjugates; pHPMA | 2015-12 |
| 46 |
 |
Johnson, Rhiannon | Thermal modulation of the semicircular canal afferent response in the oyster toadfish, opsanus tau | Current cochlear implant devices provide limited hearing ability to the deaf through electrical stimulation of the auditory nerve. Recent studies have shown that pulsed infrared (IR) radiation can also be used to stimulate the inner ear neurons and has the potential to be used in prostheses to help ... | Biomedical Engineering | 2012-05 |
| 47 |
 |
Wang, Karissa M. | Transcription factor NFATc1's signaling pathway and role in cardiomyocyte function | Atrial fibrillation (AF) is the most common sustained arrhythmia. It affects as many as 6.1 million people in the United States and increases their risk of stroke by 4-5 times. AF is evidently a very serious condition, but the scientific community does not yet fully understand its underlying mechani... | 2020 | |
| 48 |
 |
Leyendecker, Peyton | Unraveling the Q system function in prokaryotes | Expanding the prokaryotic synthetic biology toolbox is a promising strategy for enhancing control of gene expression. More specifically, understanding the eukaryotic Q system activation of the T7 promoter in prokaryotes can enable enhanced engineering applications for research and biomedicine. Here,... | 2024 | |
| 49 |
 |
Wankier, Zakary S. | Use of computer tomography imaging to observe increased distal-end cortical bone around a percutaneous osseointegrated implant | Osseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an e... | 2022 | |
| 50 |
 |
Tiwari, Sarthak | Utilizing light scattering spectroscopy and machine learning to differentiate heterogenous tissue samples | Current biopsy approaches either lack depth penetration or real-time analysis. Light scattering spectroscopy (LSS) aims to address these issues, and our goal is to investigate the use of LSS for identifying cardiac conduction tissues. LSS data were collected from donor tissue samples and created a 3... | 2023 |