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Creator | Title | Description | Subject | Date |
| 226 |
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Capecchi, Mario R. | Gene targeting. How efficient can you get? | With targeting in Leishmania and Trypanosoma, there are now greater incentives to develop the technology in organisms of intermediate complexity such as Caenorhabditis elegans and Drosophila. The ratio of homologous to nonhomologus recombination in these organisms might prove to be greater than in m... | Animals; DNA Mutational Analysis; Recombination, Genetic | 1990-11-08 |
| 227 |
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Capecchi, Mario R. | Gene targeting: an historical perspective | Our entry into what was going to become the field of gene targeting began in 1977. I was experimenting with the use of extremely small glass needles to inject DNA directly into the nuclei of living cells. The needles were controlled by hydraulically driven micro-manipulators and were directed into n... | Gene targeting -- History; Homologous recombination | 1998 |
| 228 |
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Capecchi, Mario R. | Gene targeting: tapping the cellular telephone. | Gene targeting means that we now have the potential to generate mice of virtually any desired genotype. In the first instance, standards recombinant DNA technology is used to alter a cloned DNA sequence of a chosen locus; the modified potent stem cell derived from a mouse embryo, and homologous reco... | Animals; Blotting, Southern; Bone and Bones; Gene Targeting; Genotype; Immunochemistry; In Situ Hybridization; Mice | 1990-03-08 |
| 229 |
 |
Adler, Frederick R. | General test for interaction modification | How can measurements of population dynamics be used to deduce the mechanisms of interaction in an assemblage of species? We present a technique to use such measurements to distinguish among assemblages of species with no direct interactions, sets of species influenced predominantly by pairwise inter... | Species; Population; Dynamics | 1994 |
| 230 |
 |
Capecchi, Mario R. | Generating mice with targeted mutations. | Mutational analysis is one of the most informative approaches available for the study of complex biological processes. It has been particularly successful in the analysis of the biology of bacteria, yeast, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Extension ... | Animals; Recombination, Genetic; Stem Cells | 2001-10-01 |
| 231 |
 |
Beckerle, Mary C.; Hoffman, Laura M.; Yoshigi, Masaaki | Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling | Focal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene... | Zyxin; Actin; Mena/VASP | 2006 |
| 232 |
 |
Clayton, Dale H.; Rogers, Alan R. | Genetic analysis of lice supports direct contact between modern and archaic humans | Parasites can be used as unique markers to investigate host evolutionary history, independent of host data. Here we show that modern human head lice, Pediculus humanus, are composed of two ancient lineages, whose origin predates modern Homo sapiens by an order of magnitude (ca. 1.18 million years). | Pediculus humanus; Head lice; Molecular phylogeny; Phthirus | 2004 |
| 233 |
 |
Adler, Frederick R. | Genetic and phylogenetic consequences of island biogeography | Island biogeography theory predicts that the number of species on an island should increase with island size and decrease with island distance to the mainland. These predictions are generally well supported in comparative and experimental studies. These ecological, equilibrium predictions arise as a... | Extinction; Genetic divergence; Island isolation; Migration; Speciation | 2000 |
| 234 |
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Shapiro, Michael D. | Genetic architecture of parallel armor plate reduction in threespine sticklebacks | How many genetic changes control the evolution of new traits in natural populations? Are the same genetic changes seen in cases of parallel evolution? Despite long-standing interest in these questions, they have been difficult to address, particularly in vertebrates. We have analyzed the genetic bas... | Genetic changes; Plate number; Genetic mapping | 2004 |
| 235 |
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Shapiro, Michael D. | Genetic architecture of skeletal convergence and sex determination in ninespine sticklebacks | The history of life offers plentiful examples of convergent evolution, the independent derivation of similar phenotypes in distinct lineages [1]. Convergent phenotypes among closely related lineages (frequently termed "parallel" evolution) are often assumed to result from changes in similar genes or... | Convergent evolution; Skeletal convergence; Pungitius pungitius; Gasterosteus aculeatus; Comparative genetics | 2009-07 |
| 236 |
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Capecchi, Mario R. | Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. | hoxb-5 and hoxb-6 are adjacent genes in the mouse HoxB locus and are members of the homeotic transcription factor complex that governs establishment of the mammalian body plan. To determine the roles of these genes during development, we generated mice with a targeted disruption in each gene. Three ... | Alleles; CCAAT-Enhancer-Binding Proteins; Cervical Vertebrae; DNA-Binding Proteins; Forelimb; Genetic Complementation Test | 1995-01-01 |
| 237 |
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Jorgensen, Erik | Genetic screens for synaptic function mutants in the nematode C. elegans | The synapse is the site of a remarkable conversion of electrical signals into chemical signals. This conversion takes place when a depolarizing impulse enters the axon terminal and opens voltage-sensitive calcium channels; calcium then flows into the cell and initiates the fusion of synaptic vesicle... | Vesicle; Neurotransmission; Cell | 1996 |
| 238 |
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Rogers, Alan R.; Harpending, Henry C. | Genetic structure of ancient human populations | Discusses mitochondrial DNA (mtDNA) sequences as important source of data about the history of human species. | Tree of descent; Mismatch distributions; Simulations; Findings; Intermatch distributions; Younger and older populations | 2001-09-15 |
| 239 |
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| Genetics in Utah : NPR talk of the nation, science Friday for May 15, 1998 | This is a 1 hour, 9 seconds audio transcript of National Public Radio's Science Friday that was taped at Westminster College of Salt Lake on 1998/05/15. The host, Ira Flatow, leads a panel composed of University of Utah scientists and researchers, Jeffrey Bodkin, Mario Capecchi, Ray Gesteland, Mark... | Genetic engineering; Molecular genetics; Capecchi, Mario R.; Homeobox genes; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis | 1998 |
| 240 |
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Parkinson, John Stansfield | Genetics of bacterial chemotaxis | Many types of motile bacteria are capable of detecting and responding to changes in their environment. Phototactic, chemotactic and thermotactic movements in bacteria are similar to more complex behaviours seen in higher organisms, and constitute useful model systems for investigating the molecular ... | Bacterial chemotaxis | 1981 |
| 241 |
 |
Potts, Wayne K. | Gong method for capturing shorebirds and other ground-roosting species | In many shorebird studies it is necessary to capture adult birds. While shorebirds can often be trapped on the nest, capturing them away from the nest is usually very difficult and may require expensive equipment. After weeks of failure in our attempts to capture migrant and resident shorebirds in n... | Gong method; Shorebirds; Capture; Ground-roosting | 1979 |
| 242 |
 |
Davidson, Diane W. | Granivory in a desert ecosystem: experimental evidence for indirect facilitation of ants by rodents | Two major groups of desert granivores, ants and rodents, coexist as permanent residents of local desert habitats in southwestern North America. At our Sonoran Desert study site, both of the major taxa exhibited short-term increase in density when the other taxon was experimentally removed. Over the... | Ants; Arizona; Desert annuals; Facilitation; Granivory; Indirect mutualism; Rodents; Seed predation; Sonoran Desert | 1984 |
| 243 |
 |
Davidson, Diane W. | Granivory in the Chihuahuan Desert: interactions within and between trophic levels | We investigated the effects of Chihuahuan Desert granivores on three seasonal classes of plant resource species, the effects of these resource classes on one another, and the ways in which interactions through plant resources affect the abundances of seed consumers. At our study site, three seasona... | Annual plant; Ant; Competition; Community; Desert; Ecosystem structure; Experiment; Granivore; Indirect interaction; Rodent; Population cycles; Seed predation | 1985 |
| 244 |
 |
Davidson, Diane W. | Granivory in the Chihuahuan desert: interactions within and between trophic levels | We investigated the effects of Chihuahuan Desert granivores on three seasonal classes of plant resource species, the effects of these resource classes on one another, and the ways in which interactions through plant resources affect the abundances of seed consumers. At our study site, three seasona... | Annual plant; Ant; Competition; Community; Desert; Ecosystem structure; Experiment; Granivore; Indirect interaction; Rodent; Population cycles; Seed predation | 1985 |
| 245 |
 |
Bastiani, Michael | Growth cone dynamics during the migration of an identified commissural growth cone | We have used time-lapse video microscopy to study the behavior of a neuron, 01, that pioneers the posterior commissure of the embryonic grasshopper. Our goal is to use time-lapse video as a tool to acquire a precise picture of normal development over time, and thereby identify stereotypic activities... | Time-lapse video; Commissure; Grasshopper; Pathfinding; Filopodia; Confocal microscopy; Adhesion | 1993 |
| 246 |
 |
Coley, Phyllis D. | Growth-defense trade-off and habitat specialization by plants in Amazonian forests | Tropical forests include a diversity of habitats, which has led to specialization in plants. Near Iquitos, in the Peruvian Amazon, nutrient-rich clay forests surround nutrient-poor white-sand forests, each harboring a unique composition of habitat specialist trees. We tested the hypothesis that t... | Amazon; Ecological gradient; Growth-defense trade-off; Habitat specialization; Herbivory; Phenolics; Phylogenetic control; Rainforest; Reciprocal-transplant experiment; Terpenes; Tropical trees | 2006 |
| 247 |
 |
Ehleringer, James R. | Grupos funcionales en arbustos deserticos del norte de Chile, definidos sobre la base de las fuentes de agua utilizadas | La productividad primaria y la estructura de la vegetación en ecosistemas áridos están determinadas por la disponibilidad de agua. En un estudio realizado en el secano costero del norte-centro de Chile (29/43'S; 71/14'O, 300 m) se compararon los mecanismos de utilización de distintas fuentes de... | Grupos funcionales; Functional groups; Arbustos deserticos; Desert shrubs; Fuentes de agua; Water sources; Water availability; Arid ecosystems; Pastoreo con caprinos; Goat overgrazing | 1999-01-01 |
| 248 |
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Bastiani, Michael | Guidance of neuronal growth cones in the grasshopper embryo. I. Recognition of a specific axonal pathway by the pCC neuron | The selective affinities that growth cones display for specific axonal surfaces give rise to stereotyped patterns of selective fasciculation. Previous studies on cell recognition by neuronal growth cones in the grasshopper embryo led to the proposal and initial experimental testing of the labeled-p... | Fascicle; Axon; Affinity | 1986 |
| 249 |
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Bastiani, Michael | Guidance of neuronal growth cones in the grasshopper embryo. II. Recognition of a specific axonal pathway by the aCC neuron | In the previous paper, we experimentally analyzed the selective affinity of the pCC growth cone for the MP1/dMP2 fascicle in the grasshopper embryo. Here we describe a similar experimental analysis demonstrating the selective affinity of the aCC growth cone for the U fascicle. These results support... | Axon; Cell; Fascicle | 1986 |
| 250 |
 |
Bastiani, Michael | Guidance of neuronal growth cones in the grasshopper embryo. III. Recognition of specific glial pathways | In the previous 2 papers, we focused on the selective affinities that growth cones display for specific axonal pathways. Little is known, however, about how this orthogonal scaffold of axonal pathways in the CNS is established in the first place, and what, if any, role glia might play in these even... | CNS; Nerve; Cells | 1986 |
