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| Creator | Title | Description | Subject | Date | ||
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Olivera, Baldomero M. | Biochemical studies of ω-conotoxin GVIA; a peptide toxin inhibiting voltage-sensitive Ca++ channels | The fish-hunting cone snails use their venom to quickly paralyze their more agile prey. In the last few years, our laboratories have carried out a program of analyzing biologically active components present in the fish-hunting cone snail venoms (Cruz et al. 1985; Olivera et al. 1985). We have concen... | Conotoxins; Calcium channels; Conus geographus; Venom | 1987 |
| 2 |
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Olivera, Baldomero M. | Calcium channel antagonists: ω-conotoxin defines a new high affinity site | The ω-conotoxins, a class of Ca2+ channel antagonists from fish-hunting marine snails, have recently been described (Olivera, B. M., McIntosh, J. M., Zeikus, R., Gray, W. R., Varga, J., Rivier, J., de Santos, V., and Cruz, L. J. (1985) Science, 230, 1338-1343). One of these peptide neurotoxins... | Conotoxins; Calcium channels; Synaptosomes; Neurotoxins | 1986 |
| 3 |
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Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. Michael | Neuronal calcium channel inhibitors: synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomes | We previously described a 27-amino acid peptide neurotoxin from the venom of Conus geographus, wconotoxin GVIA, which inhibits neuronal voltage-activated calcium channels. In this paper we describe the total synthesis of ω-conotoxin GVIA and demonstrate that it efficiently blocks voltage-activat... | Neuronal calcium; Calcium channels; Channel inhibitors; [omega]-conotoxin GVIA | 1987 |
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