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Creator | Title | Description | Subject | Date |
| 326 |
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| KSL News clip of Mario Capecchi receiving the National Medal of Science for 1991 | This 1 minute, 44 seconds news clip from Salt Lake City's KSLTV, Channel 5 shows Mario Capecchi receiving the National Medal of Science for 1991 from President George W. Bush at the June 13, 2002 awards ceremony. The medal was presented for Capecchi's work in genetics and his development of the pro... | Transgenic mice; Gene targeting; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news | 1992-06 |
| 327 |
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| KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997 | This 3 minutes, 1 second video clip from Salt Lake City's KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases. | Gene targeting; Genetic engineering; Molecular genetics; Cancer Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Television feature stories | 1997-11-09 |
| 328 |
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Capecchi, Mario R. | Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice | While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin level... | | 2000 |
| 329 |
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Capecchi, Mario R. | Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice | While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels... | ACE | 2000-10-31 |
| 330 |
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Sekercioglu, Cagan | Landscape constraints on functional diversity of birds and insects in tropical agroecosystems | In this paper, we analyze databases on bird and insects to assess patterns of functional diversity in human-dominated landscapes in the tropics. Perspective from developed landscapes is essential for understanding remnant natural ecosystems, because most species experience their surroundings at spat... | | 2008-01-01 |
| 331 |
 |
Goller, Franz | Lateralization as a symmetry breaking process in birdsong | The singing by songbirds is a most convincing example in the animal kingdom of functional lateralization of the brain, a feature usually associated with human language. Lateralization is expressed as one or both of the bird's sound sources being active during the vocalization. Normal songs require ... | Lateralization; Syringeal muscles; Respiration; Gating | 2007-03 |
| 332 |
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Capecchi, Mario R. | Lessons from angiotensin-converting enzyme-deficient mice | Since the first description of renin by Tigerstedt and Bergman [1] in 1898, many papers have described the biochemistry and physiological roles of the reninangiotensin system [2]. A critical component of this system is angiotensin-converting enzyme (ACE), a peptidase which cleaves the inactive pep... | | 1996 |
| 333 |
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Capecchi, Mario R. | Lessons from angiotensin-converting enzyme-deficient mice. | Mice which lack ACE have low systolic blood pressure, reduced male fertility and a renal abnormality characterized by medullary hypoplasia and the inability to concentrate urine. The diverse phenotypes caused by inactivation of a single gene emphasize the many functional roles of ACE and the renin-q... | Blood Pressure; Cell Line;Fertility; Kidney; Testis | 1991-11-01 |
| 334 |
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Beckerle, Mary C. | LIM domain-containing protein Trip6 can act as a coactivator for the v-Rel transcription factor | The retroviral oncoprotein v-Rel is a transcriptional activator in the Rel/NF-KB family of eukaryotic transcription factors. v-Rel malignantly transforms a variety of cell types in vitro and in vivo, and its transforming activity is dependent on the ability of v-Rel to bind to DNA and activate trans... | LIM domains; Oncoproteins; v-Rel; Retroviral oncogene; Trip6; Coactivator; Malignant transformation; NF-kB; Two-hybrid assay | 1999 |
| 335 |
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Beckerle, Mary C. | LIM proteins in actin cytoskeleton mechanoresponse | The actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration. Stress fibers are contractile, actomyosin structures that physically couple to the extracellular matrix through ... | | 2014-01-01 |
| 336 |
 |
Shapiro, Michael D. | Limb diversity and digit reduction in reptilian evolution | The study of morphological rules, or trends, offered classical biologists the opportunity to address the mechanisms underlying the evolution of anatomical designs. Regularities in evolution suggested that common functional or developmental rules governed the transformation of structures. Parallelism... | Digit loss; Morphology; Adaptation | 2006 |
| 337 |
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| Local television news clips for June 14, 1994 featuring Mario Capecchi | This is a compilation of news clips from Salt Lake City's four major commercial television stations (Channels 2, 4, 5, and 13) lasting a total of 2 minutes, 59 seconds. The topic is Capecchi's winning of the General Motors Corporation's Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contrib... | Transgenic mice; Gene targeting; Cancer - Research - Awards; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news | 1994-06-14 |
| 338 |
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Olivera, Baldomero M.; ; McIntosh, J. Michael | Localization of [125I] ω-conotoxin GVIA binding in human hippocampus and cerebellum | THE peptide toxin ω-conotoxin GVIA (ω-CgTx) has been shown to be a high affinity ligand for N-type calcium channels in the brain. We have employed [125I]ω-CgTx to localize N-type channels in human hippocampus and cerebellum using autoradiography. Ten micron thick slidemounted tissue sections of... | Conotoxins; Peptide toxins | 1993 |
| 339 |
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Capecchi, Mario R. | Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. | Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and... | Animals; Base Sequence; Genes, Viral; Plasmids; Thymidine Kinase | 1983-07-01 |
| 340 |
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Thomas, Kirk R.; Capecchi, Mario R. | Location of crossovers during gene targeting with insertion and replacement vectors. | Gene targeting was used to introduce nonselectable genetic changes into chromosomal loci in mouse embryo-derived stem cells. The nonselectable markers were linked to a selectable marker in both insertion- and replacement-type vectors, and the transfer of the two elements to the Hprt locus was assaye... | Genetic Vectors; Molecular Sequence Data; Restriction Mapping | 1993-04 |
| 341 |
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Adler, Frederick R. | Long-term models of oxidative stress and mitochondrial damage in insulin resistance progression | Insulin resistance, characterized by a reduced cellular response to insulin, is a major factor in type 2 diabetes pathogenesis, with a complex etiology consisting of a combination of environmental and genetic factors. Oxidative stress, which develops through an accumulation of toxic reactive oxygen ... | | 2014-01-01 |
| 342 |
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Bastiani, Michael | Loss of axons in the cat optic nerve following fetal unilateral enucleation: an electron microscopic analysis | Between the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population of the E-48 nerve was estimated to be 328,000. In contrast, estimates from two normal adults were 159,... | Ganglion cell death; Retinofugal projection; Retinal ganglion cell axons | 1983 |
| 343 |
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Goller, Franz | Low-dimensional dynamical model for the diversity of pressure patterns used in canary song | During song production, oscine birds produce large air sac pressure pulses. During those pulses, energy is transferred to labia located at the juncture between the bronchii and the trachea, inducing the high frequency labial oscillations which are responsible for airflow modulations, i.e., the utt... | Serinus canarias; Air sac pressure | 2009-04 |
| 344 |
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Adler, Frederick R.; Liou, Theodore G.; Cahill, Barbara C. | Lung transplantation and survival in children with cystic fibrosis | The effects of lung transplantation on the survival and quality of life in children with cystic fibrosis are uncertain. We used data from the U.S. Cystic Fibrosis Foundation Patient Registry and from the Organ Procurement and Transplantation Network to identify children with cystic fibrosis who were... | Life; Infection; Risk; Harm | 2007 |
| 345 |
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Linton, Matthew J. | Magnitude and mechanisms of disequilibrium between predawn plant and soil water potentials | Predawn plant water potential (Uw, measured with leaf psychrometers) and surrogate measurements made with the pressure chamber (termed Upc here) are used to infer comparative ecological performance, based on the expectation that these plant potentials reflect the wettest soil Uw accessed by roots. T... | Roots; Transpiration; Solutes | 2003 |
| 346 |
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Adler, Frederick R.; Feener, Donald H. | Maintaining diversity in an ant community: modeling, extending, and testing the dominance-discovery trade-off | Ant communities often consist of many species with apparently similar niches. We present a mathematical model of the dominance-discovery trade-off, the trade-off between the abilities to find and to control resources, showing that it can in principle facilitate the coexistence of large numbers of s... | Coexistence; Dominant species; Parasitoid | 2007 |
| 347 |
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Thomas, Kirk R.; Capecchi, Mario R. | Maintenance of functional equivalence during paralogous Hox gene evolution. | Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp... | Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice | 2000-02-10 |
| 348 |
 |
Bohs, Lynn A. | Major clades in Solanum based on ndhF sequence data | Analysis of sequence data from the chloropiast gene ndhF identifies at least 12 major well-supported clades within the genus Solanum. These are briefly described, given informal clade names, and compared with the groups recognized by previous Solanum workers. Non-molecular synapomorphies are propos... | Solanum; ndhF | 2005 |
| 349 |
 |
Potts, Wayne K. | Major histocompatibility complex heterozygote superiority during coinfection | Genes of the major histocompatibility complex (MHC) play a critical role in immune recognition, and many alleles confer susceptibility to infectious and autoimmune diseases. How these deleterious alleles persist in populations is controversial. | Pathogen; MHC; Homozygotes | 2003 |
| 350 |
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Potts, Wayne K.; Granger, Donald Lee | Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice | To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is th... | MHC-congenic; Host resistance; Infection | 2003 |
