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1 Seger, Jon1998 Sewall Wright Award: William Donald HamiltonThe Sewall Wright Award was established in 1991 to honor active investigators who have contributed in especially significant ways to the conceptual unification of the biological sciences. This year's recipient is William D. Hamilton of Oxford University. Beginning in the 1960s with his papers on the...Evolution; Biological; Research1999
2 Olivera, Baldomero M.?O-Conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2The ?O-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (NaV1.8) and could therefore ...2007
3 Sekercioglu, CaganA birders quide to TurkeyAs I write, it is early December and the woods outside my window lay dusted with snow like a holiday card by Currier and Ives. A minute ago, I looked up and caught a glimpse of an adult Cooper's Hawk dashing swiftly through the trees. It swooped up, landed on a branch, then briefly shook its tail an...2006-01-01
4 Dale, ColinA novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbiosesDespite extensive study, little is known about the origins of the mutualistic bacterial endosymbionts that inhabit approximately 10% of the world's insects. In this study, we characterized a novel opportunistic human pathogen, designated ‘‘strain HS,'' and found that it is a close relative of th...2012-01-01
5 Crespo, Jose GuillermoA review of chemosensation and related behavior in aquatic insectsInsects that are secondarily adapted to aquatic environments are able to sense odors from a diverse array of sources. The antenna of these insects, as in all insects, is the main chemosensory structure and its input to the brain allows for integration of sensory information that ultimately ends in b...2011-09-13
6 Adler, Frederick R.A time since recovery model with varying rates of loss of immunityFor many infectious diseases, immunity wanes over time. The majority of SIRS models assume that this loss of immunity takes place at a constant rate. We study temporary immunity within a SIRS model structure if the rate of loss of immunity can depend on the time since recovery from disease.We determ...2012-01-01
7 Olivera, Baldomero M.; McIntosh, J. Michael; Hillyard, David R.A-superfamily of conotoxins: structural and functional divergenceThe generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in stru...Conotoxins; A-superfamily conotoxin2004-02-03
8 Ehleringer, James R. ; Cerling, Thure E.Aberrant water homeostasis detected by stable isotope analysisWhile isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition...2010-07-21
9 Capecchi, Mario R.Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra...Alleles; Animals; Bone and Bones; Carpal Bones2003-09-02
10 Beckerle, Mary C.Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human plateletsTalin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.Talin1989
11 Shapiro, Michael D.Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancerThe molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred by regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox t...Adaptive evolution; Pelvic reduction; Pituitary homeobox transcription factor 1; Pitx1; Gasterosteus aculeatus2010-01-14
12 Beckerle, Mary C.Adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to the tumor-promoting phorbol esterTalin is a high molecular weight phosphoprotein that is localized at adhesion plaques. We have found that talin phosphorylation increases 3.0-fold upon exposure of chicken embryo fibroblasts to the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate.Talin; Vinculin; Chicken embryo fibroblasts1990
13 Adler, Frederick R.Aggregation and stability in parasite-host modelsThis paper generalizes the two-dimensional approximation of models of macroparasites on homogeneous populations developed by Anderson & May (1978), focusing on how the dispersion (the variance to mean ratio) of the equilibrium distribution of parasites on hosts is related to the stability of the equ...Aggregation; Stability; Host-parasite models1992-04
14 Coley, Phyllis D.; Lokvam, John; Kursar, Thomas A.Allelochemic function for a primary metabolite: the case of L-tyrosine hyper-production in Inga umbellifera (Fabaceae)Young leaves of tropical forest trees experience far higher herbivory pressure than mature leaves of the same species. Selection on young leaves has led to diverse forms of defense chemical expression. Though most allelochemicals are secondary metabolites, allelochemic function for a primary metabol...5-amino-4-hydroxy-pentanoic acid; Panama; Barro Colorado Island; Fabaceae; Inga umbellifera; Primary metabolite; Heliothis virescens2006
15 Beckerle, Mary C.ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegansMutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot...Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin2009
16 Capecchi, Mario R.Altered enzymes in drug-resistant variants of mammalian tissue culture cells.Two selective procedures are compared in an effort to isolate variants of mouse L cells containing structural gene mutations. Among the resulting variant cloned cell lines are found two types of alterations in theenzyme hypoxanthine phosphoribosyl transferase (EC 2.4.2.8.) (1): enzyme with altered ...Drug Resistance; Azaguanine; Clone Cells; Hypoxanthines1973-11
17 Adler, Frederick R.Alternating host cell tropism shapes the persistence, evolution and coexistence of Epstein-Barr virus infections in humanEpstein-Barr virus (EBV) infects and can persist in a majority of people worldwide. Within an infected host, EBV targets two major cell types, B cells and epithelial cells, and viruses emerging from one cell type preferentially infect the other. We use mathematical models to understand why EBV infec...2011
18 Adler, Frederick R.Alternating host cell tropism shapes the persistence, evolution and coexistence of Epstein-Barr virus infections in humanEpstein-Barr virus (EBV) infects and can persist in a majority of people worldwide. Within an infected host, EBV targets two major cell types, B cells and epithelial cells, and viruses emerging from one cell type preferentially infect the other. We use mathematical models to understand why EBV infec...2010
19 Olivera, Baldomero M.Alternative splicing in the pore-forming region of shaker potassium channelsWe have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 59 and 39 ends of the coding region. However, in Panulirus shaker, alternative splicing also occurs within the pore-forming...Panulirus interruptus; Conotoxins; Shaker; Stomatogastric ganglion; Pore-forming region; Alternative splicing1997
20 Coffin, Cheryl M.; Capecchi, Mario R.Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has...Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors2004-11-01
21 Olivera, Baldomero M.Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicityTo the Editor: Since ototoxicity and neuromuscular toxicity of aminoglycoside antibiotics are reversed by calcium, 1,2 and presynaptic events appear to be involved in aminoglycoside-induced neuromuscular blockade, 3,4 we suspected a role for voltage-sensitive calcium channels in aminoglycoside neuro...Conotoxins1987
22 Clayton, Dale H.An experimental test of the effects of behavioral and immunological defenses against vectors: do they interact to protect birds from blood parasites?Background: Blood-feeding arthropods can harm their hosts in many ways, such as through direct tissue damage and anemia, but also by distracting hosts from foraging or watching for predators. Blood-borne pathogens transmitted by arthropods can further harm the host. Thus, effective behavioral and im...2014-01-01
23 Parkinson, John StansfieldAn unorthodox sensory adaptation site in the E. coli serine chemoreceptorThe serine chemoreceptor of E. coli contains four canonical methylation sites for sensory adaptation that lie near inter-subunit helix interfaces of the Tsr homodimer. An unexplored fifth methylation site, E502, lies at an intra-subunit helix interface, closest to the HAMP domain that controls input...2014-01-01
24 Sperry, John S.Analysis of circular bordered pit function I. Angiosperm vessels with homogenous pit membranesA model predicted pit and vessel conductivity, the air-seed pressure for cavitation, and the implosion pressure causing vessel collapse. Predictions were based on measurements from 27 angiosperm species with circular bordered pits and air-seed pressures of 0.2-11.3 MPa. Vessel implosion pressure exc...Functional wood anatomy; hydraulic architecture; plant biomechanics2004
25 Sperry, John S.Analysis of circular bordered pit function II. Gymnosperm tracheids with torus-margo pit membranesA model of xylem conduit function was applied to gymnosperm tracheids with torus-margo pit membranes for comparison with angiosperm vessels. Tracheids from 17 gymnosperm tree species with circular bordered pits and air-seed pressures from 0.8 to 11.8 MPa were analyzed. Tracheids were more reinforced...Functional wood anatomy; hydraulic architecture; plant biomechanics2004
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