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Filters: Collection: "ir_htoa" Subject: "research"
1 - 25 of 5
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Arave, Rowan A. | AKT1 activation promotes the development of melanoma metastasis | Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu... | Melanoma; genetics; research; metastasis; genetics; research; biochemistry; genetics | 2015-12 |
| 2 |
 | Edwards, Jennifer Lynn | Application of a TBHP-mediated Wacker-type oxidation to internal alkenes | The Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ... | Wacker-type oxidatioin; research; TBHP | 2013-05 |
| 3 |
 | Anjewierden, Scott | Automated kinematic analysis of pre-pluse inhibition in larval zebrafish | Animals differentially ignore or attend to sensory information depending on their immediate environment. A significant example of this phenomenon is audiomotorpre-pulse inhibition (PPI), in which the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This a... | Zebra danio; development; kinematics; research; kinematic parameters; swim kinematics; pre-pulse inhibition | 2014-12 |
| 4 |
 | Tanner, Trevor | The automation of a discontinuous membrane extruder | One quarter of American troop deaths in the Middle East were classified as "potentially survivable." Of these, over 90 percent of the battlefield deaths and over 80 percent of the deaths in treatment centers were attributed to one factor: blood loss. Blood's limited supply, short half-life, and r... | Blood; transfusion; research; membrane homogenization; synthetic blood; artificial oxygen carriers | 2016-05 |
| 5 |
 | Estrada, Johanna | BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemia | CML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ... | Leukemia; genetic aspects; research leukemia; treatment; research | 2014-04 |
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