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Creator | Title | Description | Subject | Date |
| 376 |
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Blair, David F. | MotA protein of E. coli is a proton-conducting component of the flagellar motor | A number of mutants of motA, a gene necessary for flagellar rotation in E. coli, were isolated and characterized. Many mutations were dominant, owing to competition between functional and nonfunctional MotA for a limited number of sites on the flagellar motor. A new class of mutant was discovered... | MotA protein; MotA gene; Flagellar motor; Proton-conducting | 1990 |
| 377 |
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Goller, Franz | Motor control of crystallized song is modified by sensory feedback | Song production requires precisely coordinated activity in the respiratory and syringcal (vocal organ) muscles. Crystallized adult song is characterized by acoustic and motor stereotypy which does not require auditory feedback, suggesting it is represented by fixed central motor programs. To determ... | Air injection; Auditory feedback; Pressure | 1997 |
| 378 |
 |
Goller, Franz | Motor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tension | Frequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing to... | | 2014-01-01 |
| 379 |
 |
Lawton, Kristy J. | Motor neurons tune premotor activity in a vertebrate central pattern generator | Central patterns generators (CPGs) are neural circuits that drive rhythmic motor output without sensory feedback. Vertebrate CPGs are generally believed to operate in a top-down manner in which premotor interneurons activate motor neurons that in turn drive muscles. In contrast, the frog (Xenopus la... | CPG; feed back; synchrony; vocal; vocalization; Xenopus | 2017 |
| 380 |
 |
Eichwald, Ernst; Capecchi, Mario R.; Thomas, Kirk R. | Mouse model for the delta F508 allele of cystic fibrosis | The most common cause of cystic fibrosis is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance regulator (CFTR). The delta F508 protein is misprocessed and degraded rather than traveling to the apical membrane. We used a novel strategy to introduce the delta F508 ... | Digestive System; Disease Models, Animal; Electrolytes; Mice, Inbred C57BL | 1995-10 |
| 381 |
 |
Olivera, Baldomero M. | Multiple bromotryptophan and y-carboxyglutamate residues in a Conus peptide | A novel peptide was purified from Conus textile venom which caused hyperactivity in mice. The 31-amino acid peptide has six residues with unusual post-translational modifications: four y-carboxyglutamates and two brominated tryptophan residues. This peptide, which we have designated the dibromorunn... | | 1999-01-01 |
| 382 |
 |
Jorgensen, Erik | Multiple transcripts from the Antennapedia gene of Drosophila melanogaster | The structures of four major transcripts from the homeotic gene Antennapedia of Drosophila melanogaster were determined. These transcripts constitute two RNA classes, each class initiating from a unique promoter but sharing 3' exons. Within the shared sequences is a major open reading frame encoding... | Mutations; Sequences ; RNA | 1986 |
| 383 |
 |
Beckerle, Mary C. | Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis | A genetic hierarchy of interactions, involving myogenic regulatory factors of the MyoD and myocyte enhancer-binding 2 (MEF2) families, serves to elaborate and maintain the differentiated muscle phenotype through transcriptional regulation of muscle-specific target genes. | LIM domains; Cysteine-rich proteins | 1999 |
| 384 |
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Goller, Franz | Muscular control and biomechanics of the songbird syrinx | In songbirds the vocal organ, the syrinx, is controlled by six bilateral muscles, the functional roles of which have been studied indirectly, but not directly. We filmed the syrinx with an endoscope while electrically stimulating individual intrinsic muscles on one side. | Syringeal; Medial labium; Vocal organ | 1997 |
| 385 |
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Baehr, Wolfgang; Frederick, Jeanne M.; Church-Kopish, Jill; Howes, Kimberly | Mutant rhodopsin transgene expression on a null background | PURPOSE. To study mechanisms leading to photoreceptor degeneration in mouse models for autosomal dominant retinitis pigmentosa (adRP) based on the rhodopsin P23H mutation. METHODS. Mice of a transgenic line expressing a rhodopsin triple mutant, V20G, P23H, and P27L (GHL), were mated with rhodopsin (... | Mutant Rhodopsin; Photoreceptor Degeneration; Autosomal Dominant Retinitis Pigmentosa; Rhodopsin | 2001-03 |
| 386 |
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Beckerle, Mary C.; Davis, Darrell R.; Winge, Dennis R. | Mutational analysis of the metal sites in an LIM domain | Site-directed mutagenesis was carried out map the residues that form the two Zn(I1) sites within a LIM domain. The C-terminal LIM domain derived from the cysteine-rich protein was utilized for this analysis and is referred to as LIMB. | LIM domains; Metal-binding | 1994 |
| 387 |
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Parkinson, John Stansfield | Mutational analysis of the P1 phosphorylation domain in E. coli CheA, the signaling kinase for chemotaxis | The histidine autokinase CheA functions as the central processing unit in the Escherichia coli chemotaxis signaling machinery. CheA receives autophosphorylation control inputs from chemoreceptors and in turn regulates the flux of signaling phosphates to the CheY and CheB response regulator proteins... | | 2014-01-01 |
| 388 |
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Beckerle, Mary C. | Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains | Drosophila Enabled (Ena) was initially identified as a dominant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of proteins. We have used genetic, biochemical, and cell biological appr... | Drosophila Ena; VASP | 1998 |
| 389 |
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Jorgensen, Erik | Mutations in synaptojanin disrupt synaptic vesicle recycling | Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhab... | | 2000 |
| 390 |
 |
Jorgensen, Erik | Mutations in β-spectrin disrupt axon outgrowth and sarcomere structure | B-Spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. B-Spectrin and the membrane skeleton have been proposed to stabilize cell membranes, generate cell polarity, or localize specific membrane proteins. We demonstrate that the Caen... | | 2000 |
| 391 |
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Capecchi, Mario R. | N-formylmethionyl-sRNA as the initiator of protein synthesis. | A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that methionine and alanine constituted start signals for the initiation of polypeptide chains. Alternative... | Electrophoresis; Formates; In Vitro; Methionine | 1966-01-01 |
| 392 |
 |
Jorgensen, Erik | Nano-fEM: Protein localization using photo-activated localization microscopy and electron microscopy | Mapping the distribution of proteins is essential for understanding the function of proteins in a cell. Fluorescence microscopy is extensively used for protein localization, but subcellular context is often absent in fluorescence images. Immuno-electron microscopy, on the other hand, can localize pr... | | 2012-01-01 |
| 393 |
 |
Seger, Jon | Natural history and evolution of paper-wasps | Paper-wasps occupy a special place in the history of animal behavior. Temperate species o f Polistes are large, beautiful, intelligent, adaptable, easy to observe, and thoroughly committed to social life. They are also aptly named, being intensely political, in the limited sense that any nonhuman an... | Individuals; Excellent; Phylogeny | 1997 |
| 394 |
 |
Sekercioglu, Cagan | The need to quantify ecosystem services provided by birds | What are birds worth-what is their actual dollar value to human society? To most of us in the ornithological community, birds are invaluable. But in these times we need more specific rationales to convince policy makers and business leaders to include bird conservation in land-use and development de... | | 2011-01-01 |
| 395 |
 |
Clayton, Dale H. | Neotropical tineidae, II: biological notes and descriptions of two new moths phoretic on spiny pocket mice in Costa Rica (Lepidoptera: Tineoidea) | Two new species of tineid moths discovered riding on the backs of two species of spiny pocket mice (Heteromyidae) in Costa Rica are described. Amydria selvae, new species, was found on Heteromys desmarestianus Gray in the rainforest at Finca La Selva and Ptilopsaltis santarosae, new species, occurr... | Neotropical Tineidae; Phoretic moths; Amydria selvae; Heteromys desmarestianus; Ptilopsaltis santarosae; Liomys salvini; Mouse moths | 1986 |
| 396 |
 |
Jorgensen, Erik | Neural plasticity | Neural plasticity refers to functional changes in the nervous system and therefore encompasses a range of phenomena from changes at synapses observed on a microscopic scale to changes in behavior observed in the whole animal. These diverse phenomena are related since changes in synapses are believ... | Synapses; Nervous System; Development | 1997 |
| 397 |
 |
Yamaguchi, Ayako | Neurocircuitry underlying vocal production of the African clawed frog, Xenopus laevis | This poster describes how motor and premotor neurons are interconnected to each other using electrophysiological and pharmacological techniques. | Vocalizations; Central pattern generator; Motor programs; Premotor neurons; Whole-cell patch-clamp recordings | 2014 |
| 398 |
 |
Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. Michael | Neuronal calcium channel inhibitors: synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomes | We previously described a 27-amino acid peptide neurotoxin from the venom of Conus geographus, wconotoxin GVIA, which inhibits neuronal voltage-activated calcium channels. In this paper we describe the total synthesis of ω-conotoxin GVIA and demonstrate that it efficiently blocks voltage-activat... | Neuronal calcium; Calcium channels; Channel inhibitors; [omega]-conotoxin GVIA | 1987 |
| 399 |
 |
Coley, Phyllis D. | New cytotoxic cinnamic acid derivatives from leaves of Bonamia trichantha | Bioassay-guided fractionation of the methanolic extract of the young leaves of Bonamia trichantha led to the isolation of four new cinnamic acid derivatives trichanthins A-D (l-4).Their structures were established by spectroscopic methods. All compounds were tested in cytotoxic assays against the MC... | Bonamia trichantha; Cinnamic acid; Caffeic acid ester; p-Coumaric acid ester: Farnesol; Z-(l l)-hexadecen-l-ol; Cytotoxicity | 2006 |
| 400 |
 |
Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robert; Hillyard, David R. | New family of conotoxins that block voltage-gated sodium channels | Conus peptides, including ω-conotoxins and α-conotoxins (targeting calcium channels and nicotinic acetylcholine receptors, respectively) have been useful ligands in neuroscience. In this report, we describe a new family of sodium channel ligands, the μO-conotoxins. | Conotoxins; Sodium channel blockers | 1995 |
