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CreatorTitleDescriptionSubjectDate
526 Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S.Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eyeUptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio...Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls2004
527 Zhang, KangIdentification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy2001
528 Baehr, WolfgangIdentification and light-dependent translocation of a cone-specific antigen, (Cone Arrestin) recognized by monoclonal antibody 7G6PURPOSE: To elucidate the antigen recognized by monoclonal antibody (mAb) 7G6, a widely used cone-specific marker. METHODS: 7G6 immunocytochemistry was performed on sections of human, primate, and bovine retina. The antigen was immunoprecipitated from human retinal lysates and purified with protein ...Cones (Retina); Molecular Sequence Data; Phototransduction2003
529 Crockett, David K.Identification of histoplasma -specific peptides in human urineHistoplasmosis is a severe dimorphic fungus infection, which is often difficult to diagnose due to similarity in symptoms to other diseases and lack of specific diagnostic tests. Urine samples from histoplasma-antigen-positive patients and appropriate controls were prepared using various sample prep...2012-01-01
530 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysisOvercoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1α and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression pro...Glioblastoma multiforme; U-251; Hypoxia; Microarray analysis; Brain tumor; Depp; Astrocytoma2007
531 Bernstein, Paul S.Identification of lutein and zeaxanthin oxidation products in human and monkey retinasPURPOSE: To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODS: Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by comparing...Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet1997
532 Pounder, June I.; Simmon, Keith E.; Barton, Claudia A.; Hohmann, Sheri L.Identification of nonsporulating molds by sequencing internal transcribed spacer regions with Virodec software and databaseFungal infections are increasing, particularly among immunocompromised hosts, and a rapid, accurate diagnosis is essential for the initiation of targeted antifungal therapy. Identification of fungi from culture requires the presence of reproductive structures, and the absence of spores can increase ...nonsporulating molds; genetic sequencing; Virodec; ITS I; ITS II2006-01-09
533 Blumenthal, Donald K.Identification of the calmodulin-binding domain of skeletal muscle myosin lightIn the course of determining the primary structure of rabbit skeletal muscle myosin light chain kinase (MLCK; ATP:protein phosphotransferase, EC 2.7.1.37) a peptide fragment was obtained that appears to represent the calmodulin-binding domain of this enzyme. Low concentrations of the peptide inhibit...Peptides; Enzymes; Protein sequence1985-05
534 Blumenthal, Donald K.Identification of the substrate and pseudosubstrate binding sites of phosphorylase kinase gamma-subunit.Using site-directed mutagenesis, we proposed that an autoinhibitory domain(s) is located at the C-terminal region (301-386) of the phosphorylase kinase gamma-subunit (Huang, C.-Y.F., Yuan C.-J., Livanova, N.B., and Graves, D.J. (1993) Mol. Cell. Biochem. 127/128, 7-18). Removal of the putative inhib...Mutagenesis; Autoinhibitory Domain; Peptides1995-03-31
535 DuVall, Scott L.Identifying data set specific duplicate patient recordsProbabilistic models are commonly used in the identification of duplicate records. These methods are usually more accurate than deterministic methods, but are exponentially more computationally complex. Thus to make them computationally feasible, they rely on deterministic blocking strategies. Th...Probabilistic models; Duplicate records; Duplicate patient records; Trapeze Interactive Poster2009
536 Caserta, Michael; Lund, Dale A.Identifying elderly with coping difficulties after two years of bereavementThis study answers three research questions. First, what proportion of the elderly are experiencing major coping difficulties after two years of bereavement? Second, what factors in early bereavement distinguish between those with difficulties and the others? Third, what set of factors are the best...Coping difficulties1985
537 Digre, Kathleen B.; Kleinschmidt, Julia J.; Hanover, RitaIdiopathic intracranial hypertension. Relationship to depression, anxiety, and quality of lifeOBJECTIVE: To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not d...Intracranial Hypertension; Depression; Anxiety; Quality of Life2000-01-25
538 Warner, Homer R.ILIAD as a Patient Case Simulator to Teach Medical Problem SolvingBiomedical Informatics1989
539 Warner, Homer R.ILIAD as an Expert Consultant to Teach Differential DiagnosisBiomedical Informatics1988
540 Warner, Homer R.The ILIAD Program: An Expert Computer Diagnostic ProgramBiomedical Informatics1992
541 Warner, Homer R.ILIAD Training Effects: A Cognitve Model and Empirical FindingsBiomedical Informatics1991
542 Warner, Homer R.ILIAD Training Enhances Medical Students' Diagnostic SkillsBiomedical Informatics1991
543 Warner, Homer R.ILIAD's Role in the Generalization of Learning Across a Medical DomainBiomedical Informatics1992
544 Warner, Homer R.ILIAD's Role in the Generaliztion of Learning Across a Medical DomainBiomedical Informatics1992
545 Capecchi, Mario R.Illegitimate cre-dependent chromosome rearrangements in transgenic mouse spermatids.The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-si...Chromatin; Female; Mice, Inbred C57BL; Phenotype2000-12-05
546 Garber, SarahImage guidance for brain metastases resectionThe primary goal in removing a metastatic brain tumor is to maximize surgical resection while minimizing the risk of neurological injury. Intraoperative image guidance is frequently used in the resection of both primary and metastatic brain tumors. Stereotactic volumetric techniques allow for smalle...2012-01-01
547 Baehr, Wolfgang; Thulin, CraigImmunolocalization and divergent roles of phosducin and phosducin-like protein in the retinaPURPOSE: These investigations were undertaken to compare and contrast the roles of phosducin and phosducin-like protein in the retina. METHODS: Phosducin and phosducin-like protein were compared in an in vitro assay measuring their inhibition of transducin binding to light-activated rhodopsin. The t...Antibody Specificity; Protein Binding; Rod Outer Segments1999
548 Couldwell, William T.Immunology and immunotherapy of intrinsic glial tumorsImmunological aspects of glial neoplasms have been actively investigated for the past several years with particular focus on academic, diagnostic, and therapeutic objectives. As more knowledge is acquired about the cellular events relating to tumor behavior the more it appears that the immune system...Immunology; Glial tumors1990
549 Caserta, Michael; Lund, Dale A.Impact of bereavement on the self-conceptions of older surviving spousesThe purpose of this longitudinal study was to assess the extent to which the social anchorage dimension of the self-concept is impacted by the death of a spouse among a sample of older surviving spouses. Social anchorage was measured by the Twenty Statements Test (TST) in mailed questionnaires and ...Social anchorage; Self-concept1986
550 Gardner, Reed M.Impact of CPOE on Mortality Rates - Contradictory Findings, Important MessagesBiomedical Informatics2006
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