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Creator | Title | Description | Subject | Date |
| 401 |
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Capecchi, Mario R. | Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. | The 180-amino acid core of the TATA-binding protein (TBPcore) is conserved from Archae bacteria to man. Vertebrate TBPs contain, in addition, a large and highly conserved N-terminal region that is not found in other phyla. We have generated a line of mice in which the tbp allele is replaced with a v... | Mice, Knockout; Cells, Cultured; Fibroblasts; Embryo | 2003-02-21 |
| 402 |
 |
Caserta, Michael; Lund, Dale A. | Future directions in adult bereavement research | The primary purpose of this article is to stimulate interest in conducting research related to adult bereavement and provide suggestions for improving the quality of these studies and the application of their findings. Future research needs to generate new knowledge about grief and bereavement but ... | | 1998 |
| 403 |
 |
Mitchell, Joyce A. | Fuzzy measures on the Gene Ontology for gene product similarity | One of the most important objects in bioinformatics is a gene product (protein or RNA). For many gene products, functional information is summarized in a set of Gene Ontology (GO) annotations. For these genes, it is reasonable to include similarity measures based on the terms found in the GO or othe... | | 2006-01-01 |
| 404 |
 |
Blumenthal, Donald K. | Gamma-subunit of skeletal muscle phosphorylase kinase contains two noncontiguous domains that act in concert to bind calmodulin. | Phosphorylase kinase is a Ca2+-regulated, multisubunit enzyme that contains calmodulin as an integral subunit (termed the delta-subunit). Ca2+-dependent activity of the enzyme is thought to be regulated by direct interaction of the delta-subunit with the catalytic subunit (the gamma-subunit) in the ... | Pharmacology; Metabolism; Enzymology | 1989-10-15 |
| 405 |
 |
Couldwell, William T. | Ganglion cyst of the temporomandibular joint with intracranial extension in a patient presenting with seventh cranial nerve palsy | Ganglion cysts arising from the temporomandibular joint are rare entities that often present with swelling and minimal to no pain in the preauricular region. To the Author's? knowledge, a temporomandibular joint ganglion cyst occurring with acute facial nerve palsy and intracranial extension has ne... | | 2012 |
| 406 |
 |
Robison, Reid Justin; Marchant, Barrie K.; Reimherr, Frederick W. | Gender differences in ADHD adults during clinical trials with atomoxetine | Introduction: Patients with ADHD exhibit several consistent gender differences, a male preponderance and more males with externalizing disorders (conduct and oppositional defiant disorder). Objective: To examine gender differences in a very large clinical trial of adults with ADHD. Methods: ... | Trapeze Interactive Poster | |
| 407 |
 |
Reimherr, Frederick W. | Gender differences in adults with ADHD, pretreatment and following treatment with atomoxetine under double-blind conditions | Boys more frequently have externalizing disorders (conduct and oppositional defiant disorder). Girls are more frequently inattentive type with increased internalizing disorders. NIMH-sponsored, multicenter MTA Study did not show these differences. This study explored gender differences in a clini... | Trapeze Interactive Poster | |
| 408 |
 |
Baehr, Wolfgang; Zhang, Kang; Kolb, Helga | Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2 | PURPOSE: To identify gene arrangement, chromosomal localization, and expression pattern of mouse guanylate cyclase activating proteins GCAP1 and GCAP2, retina-specific Ca2+-binding proteins, and photoreceptor guanylate cyclase activators. METHODS: The GCAP1 and GCAP2 genes were cloned from genomic l... | Molecular Sequence Data; Guanylate Cyclase-Activating Proteins; In Situ Hybridization, Fluorescence | 1998 |
| 409 |
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Capecchi, Mario R. | Gene targeting. How efficient can you get? | With targeting in Leishmania and Trypanosoma, there are now greater incentives to develop the technology in organisms of intermediate complexity such as Caenorhabditis elegans and Drosophila. The ratio of homologous to nonhomologus recombination in these organisms might prove to be greater than in m... | Animals; DNA Mutational Analysis; Recombination, Genetic | 1990-11-08 |
| 410 |
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Capecchi, Mario R. | Gene targeting: tapping the cellular telephone. | Gene targeting means that we now have the potential to generate mice of virtually any desired genotype. In the first instance, standards recombinant DNA technology is used to alter a cloned DNA sequence of a chosen locus; the modified potent stem cell derived from a mouse embryo, and homologous reco... | Animals; Blotting, Southern; Bone and Bones; Gene Targeting; Genotype; Immunochemistry; In Situ Hybridization; Mice | 1990-03-08 |
| 411 |
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Capecchi, Mario R. | Generating mice with targeted mutations. | Mutational analysis is one of the most informative approaches available for the study of complex biological processes. It has been particularly successful in the analysis of the biology of bacteria, yeast, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Extension ... | Animals; Recombination, Genetic; Stem Cells | 2001-10-01 |
| 412 |
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Warner, Homer R. | Generation and Maintenance of ILIAD Medical Knowledge in a Hypercard Environment | Biomedical Informatics | | 1988 |
| 413 |
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Capecchi, Mario R. | Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. | hoxb-5 and hoxb-6 are adjacent genes in the mouse HoxB locus and are members of the homeotic transcription factor complex that governs establishment of the mammalian body plan. To determine the roles of these genes during development, we generated mice with a targeted disruption in each gene. Three ... | Alleles; CCAAT-Enhancer-Binding Proteins; Cervical Vertebrae; DNA-Binding Proteins; Forelimb; Genetic Complementation Test | 1995-01-01 |
| 414 |
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Rogers, Alan R.; Harpending, Henry C. | Genetic structure of ancient human populations | Discusses mitochondrial DNA (mtDNA) sequences as important source of data about the history of human species. | Tree of descent; Mismatch distributions; Simulations; Findings; Intermatch distributions; Younger and older populations | 2001-09-15 |
| 415 |
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Camp, Nicola J. | Genetic susceptibility of prostate cancer: genome-wide screen of "non-aggressive" disease | Research has consistently shown that genetics plays a critical role in prostate cancer (CaP) development, but the identification of CaP genes has proven to be very difficult. Hereditary prostate cancer is a complex disease believed to involve numerous genes and variable penetrance. It has been propo... | CaP genes; Prostate cancer; Non-aggressive; Utah Population Database; Trapeze Interactive Poster | 2009 |
| 416 |
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| Genetics in Utah : NPR talk of the nation, science Friday for May 15, 1998 | This is a 1 hour, 9 seconds audio transcript of National Public Radio's Science Friday that was taped at Westminster College of Salt Lake on 1998/05/15. The host, Ira Flatow, leads a panel composed of University of Utah scientists and researchers, Jeffrey Bodkin, Mario Capecchi, Ray Gesteland, Mark... | Genetic engineering; Molecular genetics; Capecchi, Mario R.; Homeobox genes; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis | 1998 |
| 417 |
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Camp, Nicola J. | Genome-wide linkage analysis for aggressive prostate cancer in Utah high risk pedigrees | Research has consistently shown that genetics plays a critical role in prostate cancer (CaP) development, but the identification of CaP genes has proven to be very difficult. Hereditary prostate cancer is a complex disease involving numerous genes and variable phenotypic expression. This heterogene... | Linkage analysis; Aggressive prostate cancer; CaP genes; ICPCG; Utah; Trapeze Interactive Poster | 2009 |
| 418 |
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Bernstein, Paul S.; Leppert, Mark F. | Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings | PURPOSE: Single-copy variants of the autosomal recessive Stargardt disease (STGD1) gene ABCR (ABCA4) have been shown to confer enhanced susceptibility to age-related macular degeneration (AMD). To investigate the role of ABCR alleles in AMD further, genotype-phenotype analysis was performed on sibli... | DNA Mutational Analysis; Nuclear Family; Phenotype | 2002 |
| 419 |
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Wittwer, Carl T. | Genotyping accuracy of high-resolution DNA melting instruments | High-resolution DNA melting is a closed-tube method for genotyping and variant scanning that depends on the thermal stability of PCR-generated products. Instruments vary in thermal precision, sample format, melting rates, acquisition, and software. Instrument genotyping accuracy has not been assesse... | | 2014-01-01 |
| 420 |
 |
Mitchell, Joyce A. | Getting around in a large nomenclature file: browsing SNOMED international | We have developed a means whereby we can easily browse a very large (s 30 MB) file of a nomenclature vocabulary. "SNOMED International - A Vocabulary of Human and Veterinary Medicine" is such a file and has been proposed to serve as the basis for controlled vocabularies. The College of American Path... | | 1994-01-01 |
| 421 |
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Couldwell, William T. | Giant fusiform aneurysm in an adolescent with PHACES syndrome treated with a high-flow external carotid artery-M3 bypass | The acronym PHACES describes a rare neurocutaneous syndrome that comprises posterior fossa malformations, facial hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, eye abnormalities, and sternal defects. Facial hemangiomas constitute the hallmark of this disorder. Giant ... | | 2007 |
| 422 |
 |
Couldwell, William T. | Giant pituitary tumor combined approach | Nishioka et al. have provided a review of 29 patients with large pituitary adenomas who underwent surgery through a simultaneous transsphenoidal and transcranial approach at their institution during a 7-year period. Large adenomas with hourglass constriction, complex lobulations, and asymmetric exte... | | 2012-01-01 |
| 423 |
 |
Couldwell, William T.; Schmidt, Richard H.; Salzman, Karen L.; Chin, Steven S. | Glioblastoma multiforme of the pineal region | Glioblastoma multiforme (GBMs) tumors are exceedingly rare tumors in the pineal region. We present three cases in which patients presented with a pineal/posterior third ventricular region mass and review all the previously reported cases in the literature. Pineal region GBM seems to be a very aggre... | Glioblastoma multiforme; Hydrocephalus; Leptomeningeal dissemination; Malignant glioma; Perinaud's syndrome; Pineal region; Spinal metastases | 2006 |
| 424 |
 |
Couldwell, William T. | Glioma invasion | A characteristic pathological feature of malignant glioma cells is their ability to extensively invade surrounding brain parenchyma-particularly along white matter tracts- thus rendering focal therapies incapable of controlling tumor growth and resulting in inevitable recurrence. In this regard, ... | | 2001 |
| 425 |
 |
Olson, Randall J. | Glistenings with long-term follow-up of the Surgidev B20/20 polymethylmethacrylate intraocular lens | PURPOSE: To compare patient satisfaction with vision 12 months after implantation of a silicone or acrylic foldable intraocular lens (IOL). SETTING: John A. Moran Eye Center, University of Utah Medical Center, Salt Lake City, Utah, USA. METHODS: Selection criteria included patients who had uneventfu... | Phacoemulsification; Lens Implantation, Intraocular; Glare | 2001-10 |
