Creator | Title | Description | Subject | Date | ||
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1 |
![]() | Capecchi, Mario R. | Hox11 paralogous genes are essential for metanephric kidney induction | The mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phen... | Metanephric; Six2; Wt1 | 2002-06-01 |
2 |
![]() | Hughes, Kelly T. | Phase variation in Salmonella: analysis of Hin recombinase and hix recombination site interaction in vivo | The bacteriophage P22-based challenge phase selection was used to characterize the binding of Salmonella Hin recombinase to the wild-type hixL and hixR recombination sites, as well as to mutant and synthetic hix sequences in vivo. Hin recombinase binds to the hixL or hixR recombination sites and rep... | 1988 | |
3 |
![]() | Jorgensen, Erik | Trio's Rho-specific GEF domain is the missing Gaq effector in C. elegans | The Gaq pathway is essential for animal life and is a central pathway for driving locomotion, egg laying, and growth in Caenorhcibditis elegans, where it exerts its effects through EGL-8 (phospholipase CB [PLCB]) and at least one other effector. To find the missing effector, we performed forward ... | 2007-11-01 |