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51 Davis, Kacey A.Expression and Purification of Augertoxins: Searching for Novel Protein Folds in Venomous Marine SnailsThis study describes a method for bacterial expression and purification of previously uncharacterized proteins. The proteins chosen for this study come from auger snail toxins, which have evolved to help the snail hunt and kill their prey. Evolutionary pressure between predator and prey selects for ...2018
52 Chure, Griffin DanielFLHE influences cellular morphology through control of flagellar assembly in escherichia coliThe bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ...Escherichia coli; Flagella (Microbiology)2013-05
53 Pham, John V.The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammalsAlthough mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o...Mitochondrial disorders; Mitochondrial diseases - genetics; VMS12012-05
54 Gardner, ShalyceFunctional test for possible genetic modifiers of piga defficiencyPIGA deficiency is a rare X-linked recessive disorder that lacks effective treatment options. A protein encoded by the PIGA gene catalyzed the first step in biosynthesis of Glycosylphatidylinositol (GPI) anchors. Partial loss of function mutations in PIGA can prevent a cell from being able to synthe...2023
55 Borrowman, WilliamGas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common gardenThe majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ...Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah)2014-04
56 Loret, AmyGenetic Modifiers of Severity in Collagen VI-Related Muscular DystrophyCollagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a...heterogeneity; characterized; Resulting symptoms2019
57 Rahmati, KasraGenetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia ColiBacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW...2020
58 Acosta, LehiGenotype-dependent susceptibility to influenza and titer-virulence discordanceThe influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ...Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin2016-05
59 Willis, HannahHabitat factors influencing carnivore site usage in Sarikamis, Kars TurkeyIn a world where natural areas are increasingly developed and fragmented, an understanding of spatial ecology is critical for proper land management that benefits both people and nature. Traditionally, policy makers have relied on the use of a single, charismatic species to serve as a protective umb...2020
60 Kutschke, MichaelHip joint center differences between dual fluoroscopy, functional hip, and coda - establishing a reference standardMeasurements of joint angles, moments, and forces may be highly sensitive to positional changes in the center of a joint. Due to its deep location, the human hip joint center (HJC) can be difficult to determine. Previous studies have defined the HJC relative to external landmarks using infrared moti...Hip joint; Hip joint center2015-05
61 Thomas, NathanielThe HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of...2022
62 Lan, Yung-ChiHYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathwaySynthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an...2022
63 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
64 Fackler, Anderson N.Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegansNeurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a...2018
65 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
66 Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICUThe University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye...2023
67 Varghese, Alyssa A.Identification of virulence factors in invasive haemophilus influenzae isolates causing disease in Utah ChildrenHaemophilus influenzae can cause serious disease in children. After widespread use of the H. influenzae serotype b (Hib) vaccine, H. influenzae serotype a (Hia) became a significant cause of invasive infection in Utah. Although most Utah Hia isolates belong to a sequence type theorized to be less in...2021
68 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
69 Au, AlexanderImpact of population density of left atrial remodeling in patients with atrial fibrillationAtrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow...Atrial fibrillation Treatment2012-05
70 Pearson, CassidyMajor Urinary Protiens as a signal of genetic Quality and Infection statusThe Hamilton-Zuk hypothesis suggests that susceptibility to infectious disease is so important that many physical traits, particularly secondary sexual characters, will evolve to signal genetic quality for resistance to prospective mates. We expanded upon this theory using the house mouse (Mus muscu...2018
71 Shimko, TylerMapping suppressors of premature sperm activation in C. ElegansThe sperm of the roundworm Caenorhabditis elegans move by a crawling motion, in contrast to mammalian sperm, which exhibit a swimming motion. This method of locomotion makes the sperm of C. elegans an excellent model for examining cell motility. In order to become motile, the sperm must undergo the ...Caenorhabditis elegans -- Spermatozoa; Sperm activation2015-05
72 Guernsey, MichaelMclr is not solely responsible for pigmentation variation among domestic pigeonsFeather pigmentation in the domesticated rock pigeon, Columba livia, is stunningly diverse. Plumage pigmentation in this, and other, columbid (pigeon and dove) species plays an important role in mate choice and thus is a driving factor in the process of sexual selection. To study the genetic basis o...2012
73 Green, AustinMeasuring occupancy and occurrence of medium and large mammals in Red Butte Canyon Research Natural Area using motion-activated camera trapsWith expanding urbanization and development, human encroachment on wilderness areas continues to increase. In Utah, much of the once pristine and untouched mountain ecosystems of the Wasatch Front have been developed for recreation and other human use, and this increasing human-wildlife interaction...Red Butte Canyon (Salt Lake County, Utah); Wilderness area monitoring - United States; Wildlife conservation - Utah
74 Astin, Holly M.Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish2016
75 Astin, M. HollyModulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in ZebrafishThe liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis...Liver X receptors - Research; Zebrafish - genetics2016-08
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