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1 Kestle, John R. W.; Walker, Marion L.Adjustment and malfunction of a programmable valve after exposure to toy magnetsInadvertent adjustments and malfunctions of programmable valves have been reported in cases in which patients have encountered powerful electromagnetic fields such as those involved in magnetic resonance imaging, but the effects of small magnetic fields are not well known. The authors present a ca...2004
2 Couldwell, William T.Astrocytoma cell lineTO THE EDITOR: It has long been established clinically that patients with neurofibromatosis Type 1 (NF1) have an increased susceptibility to develop many central and peripheral tumors. The nature of the genetic alterations underlying NF1 have recently begun to be characterized. It has been demo...2001
3 Couldwell, William T.; Apfelbaum, Ronald I.Decompression of cavernous sinus meningioma for preservation and improvement of cranial nerve functionMeningiomas are the most common tumors affecting the cavernous sinus (CS). Despite advances in microsurgery and radiosurgery, treatment of CS meningiomas remains difficult and controversial. As in cases of other meningiomas, the goal of treatment for CS meningioma is long-term growth control and pre...2006-07
4 Couldwell, William T.; Chin, Steven S.Extranodal NK/T-cell lymphoma presenting as a pituitary massExtranodal NK/T-cell lymphomas are uncommon neoplasms that are highly aggressive and show a strong association with Epstein-Barr virus. They most commonly affect the nasal cavity and paranasal sinuses; manifestation as a primary pituitary tumor has never been described. The authors report a case of ...2007-09
5 Couldwell, William T.Giant fusiform aneurysm in an adolescent with PHACES syndrome treated with a high-flow external carotid artery-M3 bypassThe acronym PHACES describes a rare neurocutaneous syndrome that comprises posterior fossa malformations, facial hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, eye abnormalities, and sternal defects. Facial hemangiomas constitute the hallmark of this disorder. Giant ...2007
6 Couldwell, William T.Glioma invasionA characteristic pathological feature of malignant glioma cells is their ability to extensively invade surrounding brain parenchyma-particularly along white matter tracts- thus rendering focal therapies incapable of controlling tumor growth and resulting in inevitable recurrence. In this regard, ...2001
7 Couldwell, William T.Harvey cushing and oskar hirsch: early forefathers of modern transsphenoidal surgeryThe transnasal transsphenoidal approach is the preferred route for removal of most lesions of the sella turcica. The concept of transnasal surgery traversing the sphenoid sinus to reach the sella has existed for nearly a century. A comprehensive historical overview of the evolution of transsphenoida...2005
8 Kestle, John R. W.High incidence of tumor dissemination in myxopapillary ependymoma in pediatric patientsP Myxopapillary ependymomas (MPEs) have historically been thought to be benign tumors occurring most frequently in adults. Only 8 to 20% of these tumors occur in the first two decades of life, making this tumor a rarity in pediatric neurosurgery. Five patients with intraspinal MPEs were treated by t...2005-01
9 Couldwell, William T.Increased invasive capacity of connexin43-overexpressing malignant glioma cellsObject. Malignant glioma cells, similar to astrocytes, express connexin43 (Cx43) universally but at widely varied levels. Data from previous studies have demonstrated that malignant glioma cells form functional gap junction channels among themselves as well as with astrocytes and that such a communi...2003-12
10 Couldwell, William T.Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngiomaObject. The authors report on a cohort of patients with craniopharyngioma treated principally through transnasal (TN) resection and followed up for a minimum of 5 years. More specifically, they evaluate the role of the TN approach in the management of craniopharyngioma. Methods. Between 1984 and 19...2005-04
11 Couldwell, William T.Neurosurgical workforce trends in the United StatesObject. The purpose of this study was to evaluate the US neurosurgery workforce by reviewing journal recruitment advertisements published during the past 10 years. Methods. The number of available academic and private neurosurgical staff positions was determined based on recruitment advertisements ...2005-02
12 Kestle, John R. W.; Walker, Marion L.Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a childExtradural arachnoid cysts in the spine are relatively uncommon causes of spinal cord compression in the pediatric population that are thought to arise from congenital defects in the dura mater. Most reports describe such cysts communicating with the intrathecal subarachnoid space through a small de...2006
13 Couldwell, William T.; Orlandi, Richard R.; Apfelbaum, Ronald I.Novel closure technique for the endonasal transsphenoidal approach: Technical noteTranssphenoidal microsurgery has been the standard approach to sellar lesions since the repopularization of the technique with modifications by Dott, Guiot, and Hardy. The endonasal transseptal transsphenoidal approach, as introduced by Hirsch, is still commonly used by pituitary surgeons to remove ...2004
14 Couldwell, William T.Photophobia in a blind patient: an alternate visual pathwayPhotophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from mult...2006-11
15 Couldwell, William T.Pituitary apoplexy in the magnetic resonance imaging era: clinical significance of sphenoid sinus mucosal thickeningObject. The authors report their experience with pituitary apoplexy and evaluate the clinical significance of sphenoid sinus mucosal thickening found on magnetic resonance (MR) imaging. Methods. The cases of 28 patients (19 males and nine females) with pituitary apoplexy were reviewed retrospectiv...2006-06
16 Kestle, John R. W.Propionibacterium encephalitis [Letter to the editor]To THE EDITOR: We read with interest the article by Camarata, et al., reporting two cases of dorsal midbrain encephalitis (Camarata PJ, McGeachie RE, Haines S J: Dorsal midbrain encephalitis caused by Propionibacterium aches. Report of two cases. J Neurosurg 72." 654-659, April, 1990). There are...1990
17 Kestle, John R. W.Response to editorial: summer shuntingWe thank Dr. Scott for his review and comments about our report of shunt surgery complications in the summer. He makes two very good points. Clearly, different databases are suited for different purposes, and the NIS database used in the study by Smith and colleagues is well suited to evaluating t...2006
18 Kestle, John R. W.; Walker, Marion L.Retained peritoneal shunt tubing causing hematuriaThis 14-year-old boy with congenital hydrocephalus underwent initial shunt placement shortly after birth. During his first 6 years of life, multiple ventriculoperitoneal (VP) shunt revisions were performed to address seven shunt malfunctions and one shunt infection (Staphylococcus epidermidis). Dur...2006
19 Kestle, John R. W.Sporadic osteochondroma of the cervical spineOsteochondroma is the most common benign tumor of bone, but axial skeleton involvement is uncommon and usually indicates a hereditary cause such as osteochondromatosis (hereditary multiple exostosis). 1 Approximately 7% of hereditary osteochondromas occur along the vertebral column, which is double...2006
20 Couldwell, William T.; House, Paul A.; Salzman, Karen L.; Osborne, Anne G.; MacDonald, Joel D.; Jensen, Randy L.Surgical considerations regarding giant dilations of the perivascular spacesObject. Dilations of brain perivascular spaces (PVSs), also known as Virchow-Robin spaces, are routinely identified on magnetic resonance imaging studies of the brain and recognized as benign normal variants. Giant dilations occur only rarely and can be easily misdiagnosed as central nervous system ...2004
21 Couldwell, William T.Surgical outcomes in 118 patients with Rathke cleft cystsObject. Microscopic Rathke cleft cysts are a common incidental autopsy finding, but some Rathke cleft cysts can become sufficiently large to cause visual impairment, hypothalamic-pituitary dysfunction, and headaches. In this study patients were evaluated pre- and postoperatively to ascertain the cli...2005-02
22 Couldwell, William T.; Gillespie, David L.Ubiquitous expression of cyclooxygenase-2 in meningiomas and decrease in cell growth following in vitro treatment with the inhibitor celecoxib: potential therapeutic applicationObject. Meningiomas are the second most common symptomatic primary central nervous system tumor in adults. Findings of epidemiological studies link meningiomas with a history of head trauma, indicating a causal relationship between the inflammatory response and meningioma tumorigenesis. Cyclooxygena...2005-09
23 Kestle, John R. W.Ventriculoperitoneal shunts in children: indications, equipment and techniquesThe decision to implant a ventriculoperitoneal shunt in a child with ventriculomegaly should not be taken lightly. Once a shunt has been implanted, it is very difficult to determine that it is no longer necessary, and therefore the initial decision is very important. Sometimes the need is obvious, s...2008
24 Couldwell, William T.William Osler at McGill University: the baby professor and his early contributions to neurosurgeryBetween 1870 and 1884, as both a medical student and a member of the faculty, Sir William Osler performed approximately 1000 postmortem examinations at McGill University in Montreal. He conducted 786 of these examinations during his 7 years (1877-1884) of service as a pathologist at the M were caref...2004-10
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