UScholar Works
 
Filters: Journal Title: "Journal of Biological Chemistry" Collection: "ir_uspace"
1 - 25 of 11
Number of results to display per page
CreatorTitleDescriptionSubjectDate
1 Poulter, Charles Dale(S)-Geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesisThe first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria is the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate. The reaction is catalyzed by (S)-3-O-geranylgeranylglyceryl phosphate ((S)-GGGP) synthase...Polyacrylamide gel; Molecular weight1993-10-15
2 Poulter, Charles Dale; Davis, Darrell R.15N labeled e. coli tRNAMet, tRNAGlu, tRNATyr, and tRNAPhe. Double resonance and two dimensional NMR of H-N1 units in pseudouridineThe N1 imino units in Escherichia coli tRNAfMet, tRNAGlu, tRNAPhe, and tRNATyr were studied by 1H-15N NMR using three different techniques to suppress signals of protons not attached to 15N. Two of the procedures, Fourier internuclear difference spectroscopy and two-dimensional forbidden echo spectr...Escherichia coli; Magnetic resonance spectroscopy; Nucleic acid conformation1985-08-15
3 Poulter, Charles Dale; Davis, Darrell R.15N-labeled Escherichia coli tRNAfMet, tRNAGlu, tRNATyr, and tRNAPhe. Double resonance and two-dimensional NMR of N1-labeled pseudouridine.The N1 imino units in Escherichia coli tRNAfMet, tRNAGlu, tRNAPhe, and tRNATyr were studied by 1H-15N NMR using three different techniques to suppress signals of protons not attached to 15N. Two of the procedures, Fourier internuclear difference spectroscopy and two-dimensional forbidden echo spectr...Escherichia coli; Magnetic resonance spectroscopy; Nitrogen; Nucleic acid conformation1985-08-15
4 Poulter, Charles Dale; Davis, Darrell R.15N-labeled tRNA. Identification of dihydrouridine in Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR.The N3 imino units of dihydrouridine were identified in samples of 15N-labeled Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR. The peaks for dihydrouridine had high field 1H (9.7-9.8 ppm) and 15N (147.8-149.5 ppm) chemical shifts. Assignments were made by 1H-15N chemic...Hydrogen Bonding; Magnetic Resonance Spectroscopy; Magnetic Resonance Spectroscopy1986-03-15
5 Olivera, Baldomero M.; McIntosh, J. Michael; Hillyard, David R.A-superfamily of conotoxins: structural and functional divergenceThe generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in stru...Conotoxins; A-superfamily conotoxin2004-02-03
6 Capecchi, Mario R.ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissueDuring the recruitment process of brown adipose tissue, the mRNA level of the fatty acyl chain elongase Elovl3 is elevated more than 200-fold in cold-stressed mice. We have obtained Elovl3-ablated mice and report here that, although cold-acclimated Elovl3-ablated mice experienced an increased heat l...2005-12-21
7 Capecchi, Mario R.Role for ELOVL3 and fatty acid chain length in development of hair and skin functionVery little is known about the in vivo regulation of mammalian fatty acid chain elongation enzymes as well as the role of specific fatty acid chain length in cellular responses and developmental processes. Here, we report that the Elovl3 gene product, which belongs to a highly conserved family ...2003-12-15
8 Capecchi, Mario R.Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in miceAngiotensin-converting enzyme (ACE) produces the vasoconstrictor angiotensin II. The ACE protein is composed of two homologous domains, each binding zinc and each independently catalytic. To assess the physiologic significance of the two ACE catalytic domains, we used gene targeting in mice to int...2004-02-13
9 Olivera, Baldomero M.; McIntosh, J. Michael; Yoshikami, Dojuα-Conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptorsMany venomous organisms produce toxins that disrupt neuromuscular communication to paralyze their prey. One common class of such toxins comprises nicotinic acetylcholine receptor antagonists (nAChRs). Thus, most toxins that act on nAChRs are targeted to the neuromuscular subtype. The toxin chara...Conotoxins; Conotoxin GIC; Conus geographus; Peptide antagonists2002
10 Olivera, Baldomero M.; McIntosh, J. Michaelα-Conotoxins ImI and ImII: similar α7 nicotinic receptor antagonists act at different sitesA novel conotoxin, α-conotoxin ImII (α-CTx ImII), identified from Conus imperialis venom ducts, was chemically synthesized. A previously characterized C. imperialis conotoxin, α-conotoxin ImI (α-CTx ImI), is closely related; 9 of 12 amino acids are identical. Both α-CTx ImII and α-CTx ImI...Conotoxins; Conotoxin ImI; Conotoxin ImII2003
11 Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robertγ-Carboxyglutamate in a neuroactive toxinThe venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of γ-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence o...Conus geographus; Venom; Conotoxins; gamma-Carboxyglutamate; Neurotoxins1984
1 - 25 of 11