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Creator | Title | Description | Subject | Date |
101 |
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Olivera, Baldomero M. | Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus | We describe the purification and first biochemical characterization of an enzymatic activity in venom from the marine snail Conus magus. This enzyme, named conodipine-M, is a novel phospholipase A2 with a molecular mass of 13.6 ĸDa and is comprised of two polypeptide chains linked by one or more di... | Conotoxins; Conodipine-M; Conus magus | 1994 |
102 |
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Olivera, Baldomero M.; Gray, William Robert | Conotoxin MI: disulfide bonding and conformational states | The toxic peptide from Conus magus venom (conotoxin MI) is a 14-amino acid peptide (McIntosh, M., Cruz, L. J., Hunkapiller, M. W., Gray, W. R., and Olivera, B. M. (1982) Arch. Biochem. Biophys. 218, 329-334) which inhibits the acetylcholine ceptor. In this work we have confirmed the primary structu... | Conotoxins; Disulfide bonding; Venom; Conus magus | 1983 |
103 |
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Olivera, Baldomero M.; Hillyard, David R. | Conotoxins | Many successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1). These animals have evolved a specialized biochemistry of small constrained peptides, the conotoxins. Th... | Conotoxins | 1991 |
104 |
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Potts, Wayne K. | Consequences of self and foreign superantigen interaction with specific VB elements of the murine TCR aB | The aB T-cell receptor (TCRaB) recognizes a ligand composed of an antigen fragment complexed with a product of the major histocompatibility complex (MHC). The repertoire of receptors is limited both by the germ line of receptor variable elements and by selective events that take place during T-cell ... | Toxins; Repertoire; Expression | 1989 |
105 |
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Beckerle, Mary C.; Clark, Kathleen A. | Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans | We describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula... | LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development | 1999 |
106 |
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Adler, Frederick R. | Construction of multidimensional clustered patterns | Ecological processes often depend upon the patterning, as well as the absolute density, of resources. In this paper, we develop methods for describing pattern from the perspective of the organism encountering and exploiting the resources, and for reconstructing pattern from the description. | Algorithms; clustered resources; foraging | 1994 |
107 |
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Goller, Franz | Contributions of expiratory muscles to song production in zebra finches | Birdsong production requires coordinated activity of syringeal and respiratory muscles, Phonation occurs during the expiratory phase of the respiratory cycle, and expiratory muscles generate the pressure head for sound production. | Phonation; Syringeal muscles; Air sac pressure | 1999 |
108 |
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Olivera, Baldomero M.; Gray, William Robert | Contryphan is a D-tryptophan-containing Conus peptide | In this report, we document for the first time the occurrence of D-tryptophan in a normally translated polypeptide, contryphan. The peptide, isolated from the venom of the fish-hunting marine snail Conus radiatus, produces the "stiff-tail" syndrome in mice. | Conotoxins; Contryphan; D-tryptophan; Conus peptides; Conus radiatus; Stiff-tail syndrome | 1996 |
109 |
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Olivera, Baldomero M.; Gray, William Robert; Yoshikami, Doju | Conus geographus toxins that discriminate between neuronal and muscle sodium channels | We describe the properties of a family of 22-amino acid peptides, the μ-conotoxins, which are useful probes for investigating voltage-dependent sodium channels of excitable tissues. The μ-conotoxins are present in the venom of the piscivorous marine snail, Conus geographus L. We have purified even... | Conus geographus; Venom; Conotoxins; Sodium channels; Neurotoxins | 1985 |
110 |
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Olivera, Baldomero M.; McIntosh, J. Michael | Conus peptides as tools for the neuroscientist | Recombinant DNA technology has had a powerful impact on understanding receptors and ion channels, the key components in the nervous system that are involved in intercellular communication. Cloning genes encoding these proteins has revealed that for every receptor and ion channel type, multiple molec... | Conus peptides; Conotoxins | 1993 |
111 |
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Olivera, Baldomero M. | Conus peptides: biodiversity-based discovery and exogenomics | The venoms of the ~700 species of predatory cone snails (genus Conus) are being systematically characterized. Each Conus species contains 100-200 small, highly structured venom peptides (colloquially known as conotoxins), which are synthesized and secreted in a venom duct (for overviews, see Refs. ... | Conotoxins; Conus peptides; Exogenomics | 2006 |
112 |
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Olivera, Baldomero M. | Conus peptides: phylogenetic range of biological activity | The major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa.... | Conus peptides; Conopeptides; Conotoxins | 1992 |
113 |
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Olivera, Baldomero M. | Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacology | The predatory cone snails (Conus) are among the most successful living marine animals (~500 living species). Each Conus species is a specialist in neuropharmacology, and uses venom to capture prey, to escape from and defend against predators and possibly to deter competitors. An individual cone... | Conotoxins | 1997 |
114 |
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Goller, Franz | Coordination and synergism between visual and vocal display in the brown-headed cowbirds | Sexually selected acoustic signaling is accompanied by visual displays in many birds. The motor integration of visual and vocal displays has not been extensively studied. Brown-headed cowbirds (Molothrus ater) "puff up" prior to song, move their wings during the song and conclude with a bow. The ... | Acoustic signaling; Wing display; Synergistic interaction | 2003 |
115 |
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Sekercioglu, Cagan | Correlates of elevational specialisation in Southeast Asian tropical birds | The understanding of elevational selectivity in extremely rich tropical biotas is critical to the study of accelerating human-mediated environmental changes (e.g., deforestation and global climate warming). This paper explores the characteristics of Southeast Asian birds that are altitudinal special... | | 2012-01-01 |
116 |
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Carrier, David R. | Coupled evolution of breathing and locomotion as a game of leapfrog | Because the increase in metabolic rate related to locomotor activity places demands on the cardiorespiratory apparatus, it is not surprising that the evolution of breathing and of locomotion are coupled. As the respiratory faculty becomes more refined, increasingly aerobic life strategies can be exp... | Evolution; Coupled evolution; Breathing; Locomotion; Cardiorespiratory apparatus | 2006 |
117 |
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Capecchi, Mario R. | Critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice | Angiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta... | Blood pressure; ACE activity; Enzyme | 1997-03-06 |
118 |
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Bohs, Lynn A. | Crossing studies in Cyphomandra (Solanaceae) and their systematic and evolutionary significance | A crossing program involving eight species of Cyphomandra was instituted to elucidate systematic relationships between the taxa and evolutionary mechanisms operating in the genus. The results show that gametophytic self-incompatibility is widespread in Cyphomandra. Pollen tubes were able to reach ... | Solanum maternum; Crossing studies | 1991 |
119 |
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Beckerle, Mary C. | CRP1, a LIM domain protein implicated in muscle differentiation, interacts with α-actinin | Members of the cysteine-rich protein (CRP) family are LIM domain proteins that have been implicated in muscle differentiation. One strategy for defining the mechanism by which CRPs potentiate myogenesis is to characterize the repertoire of CRP binding partners. | CRP1; Cysteine-rich proteins; Actinin; Protein-protein interactions; LIM domains | 1997 |
120 |
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Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, Craig | Crystallization of the MS2 translational repressor alone and complexed to bromouridine | The coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ... | Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor | 1995 |
121 |
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Shapiro, Michael D. | Cynodont from the Upper Triassic of East Greenland: tooth replacement and double-rootedness | A new genus and species of cynodont from the Upper Triassic Fleming Fjord Formation of East Greenland possesses double-rooted postcanine teeth and a nonalternate pattern of tooth replacement. The specimen represents an addition to the known diversity of Early Mesozoic taxa with multi-rooted dentitio... | Mitredon cromptoni; Cynodont; Upper Triassic; East Greenland; Fleming Fjord Formation; Tooth replacement; Double-rootedness; Multi-rooted dentition | 2001 |
122 |
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Bohs, Lynn A. | Cyphomandra (Solanaceae) | Cyphomandra betacea (Cavanilles) Sendtner Syn. Cyphomandra crassifotia (Ortega) Kuntze, Solanum betacea Cavanilles, Solanwn crassifolium Ortega. Ref. FB 13(5B/1) 1962: 12; Bohs, 1986: 170. Cultivated tree. Andean II. 1000-3000 m. Voucher: Nunez et al. 8257 (MO!) Depts.: AM, CU, HU, SM | Cyphomandra; Solanum | 1993 |
123 |
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Bohs, Lynn A. | Cyphomandra (Solanaceae) | Unusual ecological aspects of Cyphomandra include its pollination syndrome and herbivore relationships. Male euglossine bees may be important pollinators of Cyphomandra flowers, and the primary attractants may not be pollen, but odor substances secreted by the anther connectives. Specialized herbi... | Cyphomandra; Latin America | 1994 |
124 |
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Beckerle, Mary C. | Cysteine-rich protein family of highly related LIM domain proteins | Here we describe a family of closely related LIM domain proteins in avian cells. The LIM motif defines a zinc-binding domain that is found in a variety of transcriptional regulators, proto-oncogene products, and proteins associated with sites of cell-substratum contact. One type of LIM-domain protei... | LIM domains; Chicken embryo fibroblasts; Quail embryo fibroblasts; Cell growth; Cell development; Cysteine-rich proteins | 1995 |
125 |
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Beckerle, Mary C. | Cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation | In this report, an antisense RNA strategy has allowed us to show that disruption of ALP expression affects the expression of the muscle transcription factors myogenin and MyoD, resulting in the inhibition of muscle differentiation. Introduction of a MyoD expression construct into ALP-antisense cells... | Skeletal muscle; PDZ-LIM protein; Actin; Actinin-associated LIM proteins; Serum response factor; Cytoskeletal architecture | 2007 |