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1 Light, Alan R.Activation of Src family kinases in spinal microglia contributes to formalin-induced persistent pain state through p38 pathwayProtein tyrosine phosphorylation has been implicated in normal and pathological functions, such as cell proliferation, migration and differentiation. Recently, some studies have shown that Src family kinases (SFKs) were involved in neurological disorders and neuropathic pain states in which microgli...2012-01-01
2 Light, Alan R.ASICs do not play a role in maintaining hyperalgesia induced by repeated intramuscular acid injectionsRepeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated acid injections, and if blockade of ASICs revers...2012-01-01
3 Digre, Kathleen B.; Gouw, Launce G.; Harris, Catherine P.; Haines, John H.; Ptacek, L.J.Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred.The autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome 6p, and SCA2 on chromosome 12q, responsible for some ADCA. W...Retinal Degeneration; Cerebellar Ataxia; Genetic Analysis1994-08
4 Jaeckle, Kurt A.; Digre, Kathleen B.; Jones, Christopher R.; Bailey, Peter L.Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction.Central neurogenic hyperventilation (CNH), for which there is no effective therapy, can eventually result in respiratory fatigue and death. This report describes a patient with CNH due to a brainstem anaplastic astrocytoma who also exhibited disturbances of sleep and ocular motor function. The CNH r...Central Neurogenic H yperventilation; Ocular Motor Dysfunction1990-11
5 Drews, Frank; Westenskow, Dwayne R.; Agutter, James A.; Strayer, David LeeDevelopment and evaluation of a anesthesia drug displayBACKGROUND: Usable real-time displays of intravenous anesthetic concentrations and effects could significantly enhance intraoperative clinical decision-making. Pharmacokinetic models are available to estimate past, present, and future drug effect-site concentrations, and pharmacodynamic models are a...Blood Pressure; Computer Graphics; Patient Simulation2002-03
6 Light, Alan R.Functional properties of tooth pulp neurons responding to thermal stimulationThe response properties of tooth pulp neurons that respond to noxious thermal stimulation of the dental pulp have been not well studied. The present study was designed to characterize the response properties of tooth pulp neurons to noxious thermal stimulation of the dental pulp. Experiments were c...2012-01-01
7 Warrier, Smitha; Lee, Alexis; Brandes, AnnaPursing Green Health: Assessing Sustainability of Medical Curriculum and Hospital Operations [recording]Medical students and UHealth staff and faculty continued their sustainability efforts during the COVID-19 pandemic by deep diving into assessment. This session of the Climate Changes Health and Health Equity Community Read will focus on the results of their efforts - The Planetary Health Report Card...Hospital operations; assessment; Medical School Curriculum; sustainability2021-12-02
8 Light, Alan R.Response to Letter by Dr. Smirmaul Group III/IV muscle afferents contribute to both perception of effort and fatigueWe thank Dr. Smirmaul for his interest in our findings, but advise caution not to over-interpret the data to address a question which would have required an entirely different study design. Specifically, the letter to the editor is strongly focused on effort perception, a variable which was, as expe...2014-01-01
9 Nguyen, Tuyet Le Thanh; Gowen, Sean Michael; Hughen, Ronald; Light, Alan R.RNA amplification of dorsal root ganglion neurons retrogradely labeled with Di-I signaling chronic pain and fatigueIn muscles, there are neurons of groups III and IV that correspond to two kinds of afferents or nerves. In previous studies regarding the responses of these afferents in skeletal muscle, singe mechanical stimuli evoked responses. Chemical stimuli are equally important, as they are responsible for ...RNA amplification; DRG neurons; Di-I; Chronic fatigue; Trapeze Interactive poster2010-03-15
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