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Capecchi, Mario R. | Hoxa1 lineage-tracing indicates a direct role for Hoxa1 in development of the inner ear, the heart and the third rhombomere | Loss of Hoxa1 function results in severe defects of the brainstem, inner ear and cranial ganglia in humans and mice as well as cardiovascular abnormalities in humans. Since Hoxa1 is expressed very transiently during an early embryonic stage, it has been difficult to determine whether Hoxa1 plays a d... | Hoxa1; Inner ear; Third rhombomere; Hindbrain; Hoxa1-IRES-Cre mouse; Embryonic development; Lineage-tracing | 2010 |
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