UScholar Works
 
Filters: Collection: "ir_uspace" Subject: "Neurotoxins"
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CreatorTitleDescriptionSubjectDate
1 Olivera, Baldomero M.Calcium channel antagonists: ω-conotoxin defines a new high affinity siteThe ω-conotoxins, a class of Ca2+ channel antagonists from fish-hunting marine snails, have recently been described (Olivera, B. M., McIntosh, J. M., Zeikus, R., Gray, W. R., Varga, J., Rivier, J., de Santos, V., and Cruz, L. J. (1985) Science, 230, 1338-1343). One of these peptide neurotoxins...Conotoxins; Calcium channels; Synaptosomes; Neurotoxins1986
2 Olivera, Baldomero M.; Gray, William Robert; Yoshikami, DojuConus geographus toxins that discriminate between neuronal and muscle sodium channelsWe describe the properties of a family of 22-amino acid peptides, the μ-conotoxins, which are useful probes for investigating voltage-dependent sodium channels of excitable tissues. The μ-conotoxins are present in the venom of the piscivorous marine snail, Conus geographus L. We have purified even...Conus geographus; Venom; Conotoxins; Sodium channels; Neurotoxins1985
3 Olivera, Baldomero M.Identification and characterization of a Ca2+-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neuronsThe afterdischarge of Aplysia bag cell neurons has served as a model system for the study of phosphorylation-mediated changes in neuronal excitability. The nature of the depolarization generating the afterdischarge, however, has remained unclear. We now have found that venom from Conus textile trig...Ca21-activated nonspecific cation channel; Slow inward current; Ion channel modulation; Afterdischarge; Bursting; Aplysia bag cell neurons; Conus textile; Neurotoxins1996
4 Olivera, Baldomero M.; Gray, William RobertInvertebrate vasopressin/oxytocin homologs: characterization of peptides from Conus geographus and Conus striatus venomsThe vasopressin-oxytocin family of peptides is of very ancient lineage, found in organisms as diverse as hydra and man. Although these peptides have been intensively studied in vertebrates, the presumably more extensive invertebrate series was defined primarily by immunological methods. In this repo...Conus geographus; Conus striatus; Venom; Conotoxins; Neurotoxins; Postsynaptic inhibition; Vasopressin-oxytocin peptides; Conopressin1987
5 Olivera, Baldomero M.; Gray, William RobertPeptide toxins from Conus geographus venomThe biochemical characterization of three highly toxic peptides from the venom of the marine snail Conus geographus is described in this report. These peptides cause their potent activity by inhibition of the postsynaptic terminus of the vertebrate neuromuscular junction. The relatively small size o...Conus geographus; Venom; Conotoxins; Neurotoxins1981
6 Olivera, Baldomero M.; Zhang, MinMin; Azam, Layla; Yoshikami, Doju; Bulaj, GrzegorzStructure/function characterization of μ-Conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channelsPeptide neurotoxins from cone snails continue to supply compounds with therapeutic potential. Although several analgesic conotoxins have already reached human clinical trials, a continuing need exists for the discovery and development of novel nonopioid analgesics, such as subtype-selective sodium c...Conotoxins; 956;-Conotoxin KIIIA; Neuronal blocker; Neurotoxins; Sodium channel blockers2007
7 Olivera, Baldomero M.; McIntosh, J. Michael; Gray, William Robertγ-Carboxyglutamate in a neuroactive toxinThe venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of γ-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence o...Conus geographus; Venom; Conotoxins; gamma-Carboxyglutamate; Neurotoxins1984
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