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Couldwell, William T.; Gillespie, David L.; Jensen, Randy L. | Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis | Overcoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1α and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression pro... | Glioblastoma multiforme; U-251; Hypoxia; Microarray analysis; Brain tumor; Depp; Astrocytoma | 2007 |
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