Erythroblastic island in bone marrow

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Title Erythroblastic island in bone marrow
Creator Poels, Lambert G.
Contributor Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen
Date 2007-12-01
Description Scheme electron microscopy. Different stages of maturing erythroblasts (2) are exposed in this scheme. The centrally localized phagocytic reticular cell (1) has many long cytoplasmic extensions that form a network with similar cells within the bone marrow. Its nucleus is irregular. The cytoplasm has a moderate amount of organelles however with a distinct variety of lysosomal structures (4). At (5) a large phagolysosome is shown that contains an expelled nucleus of an erythroblast. Different stages of maturing erythroblasts are spread around and close to the reticular cell. (3) indicates a pro-erythroblast (15-20 m) with 2-3 nucleoli, large mitochondria and numerous polysomes. (6) a basophilic erythroblast (12-18 m) or early normoblast with clumped heterochromatin in the nucleus (mitosis) and numerous polysomes. The polychromatic erythroblast or intermediate normoblast (2A) (10-12 m) marks the onset of hemoglobin synthesis in the maturing stage concomitant with a general decrease in amount of all organelles. At this time nuclear clumping starts to take place. At (2B) the orthochromatic erythroblast or late normoblast (8-12 m) shows the early stage of extrusion of the pyknotic nucleus. At (2C) an anucleate reticulocyte is shown close to an expelled pyknotic nucleus (2D).
Subtype Image
Format image/jpeg
Collection Poja Histology Collection - Blood & Bone Marrow Subset
ARK ark:/87278/s6pz8c39
Setname ehsl_heal
Date Created 2012-12-11
Date Modified 2012-12-11
ID 891001
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