| Title |
The effect of cyclophosphamide on splenic B cells (rat) |
| Creator |
Poels, Lambert G. |
| Contributor |
Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen |
| Date |
2010-06-11 |
| Subject |
cyclophosphamide; immunosupression; B lymphocytes; Mark 1 antibody |
| Description |
Stain: Immunoperoxidase staining using diaminobenzidin (DAB)/ hematoxylin counterstained on frozen section of B cells with the antibody Mark-1. The PALS area (1) contains T cells and remains unstained blue. The positively stained B cells (brown) are found in the germinal centres (2) and in the corona-marginal zone area (3). A single cyclophosphamide injection causes a severe depletion of B cells after 4 to 8 days as shown in (C), with respect to all B cell layers. Cyclophosphamide is used to induce temporarily immunosupression. |
| Subtype |
Image |
| Format |
image/jpeg |
| Collection |
Poja Histology Collection - Lymphatic Tissues and Organs Subset |
| ARK |
ark:/87278/s6dz3bks |
| Setname |
ehsl_heal |
| ID |
890918 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6dz3bks |
