White matter microstructure and atypical visual orienting in 7 month-olds at risk for autism

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Publication Type pre-print
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Creator Gerig, Guido
Other Author Elison, J. T.; Paterson, S. J.; Wolff, J. J.; Reznick, J. S.; Sasson, N. J.; Gu, H.; Botteron, K. N.; Dager, S. R.; Estes, A. M.; Evans, A. C.; Hazlett, H. C.; Schultz, R. T.; Styner, M... et.al.
Title White matter microstructure and atypical visual orienting in 7 month-olds at risk for autism
Date 2013-01-01
Description Objective: The authors sought to determine whether specific patterns of oculo-motor functioning and visual orientingcharacterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) and to identify the neural correlates of these behaviors. Method:Data were collected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteria (high-risk negative), and 41 were low- risk infants. All infants underwent an eye-tracking task at a mean age of 7 months and a clinical assessment at a mean age of 25 months. Diffusion-weighted imaging data were acquired for 84 of the infants at 7 months. Primary outcome measures included average saccadic reaction time in a visually guided saccade procedure and radial diffusivity (an index of white matter organization) in fiber tracts that included corticospinal path-ways and the splenium and genu of the corpus callosum. Results: Visual orienting latencies were longer in 7-month-old infants who ex-pressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants. Visual orienting latencies were uniquely associated with the microstructural organization of the splenium of the corpus callosum in low-risk infants, but this association was not apparent in infants later classified as having an ASD. Conclusions: Flexiblyandef ficientlyorienting to salient information in the environment is critical for subsequent cognitive and social-cognitive development. Atypical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.
Type Text
Publisher American Psychiatric Publishing
Volume 170
Issue 8
First Page 899
Last Page 908
Language eng
Bibliographic Citation Elison, J. T., Paterson, S. J., Wolff, J. J., Reznick, J. S., Sasson, N. J., Gu, H., Botteron, K. N., Dager, S. R., Estes, A. M., Evans, A. C., Gerig, G., Hazlett, H. C., Schultz, R. T., Styner, M., Zwaigenbaum, L., & Piven, J. (2013). White matter microstructure and atypical visual orienting in 7 month-olds at risk for autism. American Journal of Psychiatry, 170(8), 899-908.
Rights Management (c) American Psychiatric Publishing
Format Medium application/pdf
Format Extent 1,036,130 bytes
Identifier uspace,18993
ARK ark:/87278/s6k10dfx
Setname ir_uspace
Date Created 2016-02-02
Date Modified 2021-05-06
ID 713357
Reference URL https://collections.lib.utah.edu/ark:/87278/s6k10dfx
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