Network inefficiencies in autism spectrum disorder at 24 months

http://www.nature.com/tp/journal/v4/n5/full/tp201424a.html
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Links to Media http://www.nature.com/tp/journal/v4/n5/full/tp201424a.html
Publication Type journal article
Creator Gerig, Guido
Other Author Lewis, J.D.; Evans, A.C.; Pruett, J.R.; Botteron, K.; Zwaigenbaum, L.; Estes, A.; Collins, L.; Kostopoulos, P.; McKinstry, R.; Dager, S.; Paterson, S.; Schultz, R.; Styner, M.; Hazlett, H.; Piven, J.
Title Network inefficiencies in autism spectrum disorder at 24 months
Date 2014-01-01
Description Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral symptoms that emerge during the first years of life. Associated with these symptoms are differences in the structure of a wide array of brain regions, and in the connectivity between these regions. However, the use of cohorts with large age variability and participants past the generally recognized age of onset of the defining behaviors means that many of the reported abnormalities may be a result of cascade effects of developmentally earlier deviations. This study assessed differences in connectivity in ASD at the age at which the defining behaviors first become clear. There were 113 24-month-old participants at high risk for ASD, 31 of whom were classified as ASD, and 23 typically developing 24-month-old participants at low risk for ASD. Utilizing diffusion data to obtain measures of the length and strength of connections between anatomical regions, we performed an analysis of network efficiency. Our results showed significantly decreased local and global efficiency over temporal, parietal and occipital lobes in high-risk infants classified as ASD, relative to both low- and high-risk infants not classified as ASD. The frontal lobes showed only a reduction in global efficiency in Broca's area. In addition, these same regions showed an inverse relation between efficiency and symptom severity across the highrisk infants. The results suggest delay or deficits in infants with ASD in the optimization of both local and global aspects of network structure in regions involved in processing auditory and visual stimuli, language and nonlinguistic social stimuli.
Type InteractiveResource
Publisher Nature Publishing Group
Journal Title Translational Psychiatry
Volume 4
Issue e388
First Page 1
Last Page 11
DOI 10.1038/tp.2014.24
Language eng
Bibliographic Citation Lewis, J. D., Evans, A. C., Pruett, J. R., Botteron, K., Zwaigenbaum, L., Estes, A., Gerig, G., Collins, L., Kostopoulos, P., McKinstry, R., Dager, S., Paterson, S., Schultz, R. T., Styner, M., Hazlett, H., & Piven, J. (2014). Network inefficiencies in autism spectrum disorder at 24 months. Translational Psychiatry, 4, E388, 1-11.
Rights Management (c) Nature Publishing Group ; doi:10.1038/tp.2014.24.
Format Medium application/html
Identifier uspace, 18963
ARK ark:/87278/s6r249jf
Setname ir_uspace
Date Created 2015-04-01
Date Modified 2015-04-02
ID 712899
Reference URL https://collections.lib.utah.edu/ark:/87278/s6r249jf
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