Age-related decline in ovarian follicle stocks differ between chimpanzee (Pan troglodytes) and humans

http://www.ncbi.nlm.nih.gov/pubmed/25651885
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Links to Media http://www.ncbi.nlm.nih.gov/pubmed/25651885
Publication Type journal article
Creator Hawkes, Kristen
Other Author Cloutier, ChristinaT.; Coxworth, James E.
Title Age-related decline in ovarian follicle stocks differ between chimpanzee (Pan troglodytes) and humans
Date 2015-01-01
Description Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (Pan troglodytes) showed follicle stock decline at the same rate that human stocks decline across the same ages. Here, we correct that finding with a chimpanzee sample more than three times larger than the previous one, which also allows comparison into older ages. Analyses show depletion rates similar until about age 35, but after 35, the human counts continue to fall with age, while the change is much less steep in chimpanzees. This difference implicates likely effects on ovarian dynamics from other physiological systems that are senescing at different rates, and, potentially, different perimenopausal experience for chimpanzees and humans.
Type InteractiveResource
Publisher Springer
Journal Title Springer International Publishing
Volume 37
Issue 1
First Page 1
Last Page 9
DOI doi.org/10.1007/s11357-015-9746-4
Language eng
Bibliographic Citation Cloutier, C. T., Coxworth, J. E. & Hawkes, K. (2015). Age-related decline in ovarian follicle stocks differ between chimpanzee (Pan troglodytes) and humans. Springer, 37(1), 1-9.
Rights Management (c) Springer (The original publication is available at www.springerlink.com)(c) Springer (The original publication is available at www.springerlink.com)(c) Springer (The original publication is available at www.springerlink.com) The final publication is available at Springer via http://dx.doi.org/10.1007/s11357-015-9746-4.
Format Medium application/html
Identifier uspace, 19319
ARK ark:/87278/s6574n53
Setname ir_uspace
Date Created 2015-03-31
Date Modified 2015-03-31
ID 712888
Reference URL https://collections.lib.utah.edu/ark:/87278/s6574n53