Reduced interhemispheric connectivity in schizophrenia- tractography based segmentation of the corpus callosum

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630535/
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Links to Media http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630535/
Publication Type journal article
Creator Gerig, Guido
Other Author Kubicki, M.; Styner, M.; Bouix, S.; Markant, D.; Smith, K.; Kikinis, R.; McCarley, R. W.; Shenton, M. E.
Title Reduced interhemispheric connectivity in schizophrenia- tractography based segmentation of the corpus callosum
Date 2008-01-01
Description Background-A reduction in interhemispheric connectivity is thought to contribute to the etiology of schizophrenia. Diffusion Tensor Imaging (DTI) measures the diffusion of water and can be used to describe the integrity of the corpus callosum white matter tracts, thereby providing information concerning possible interhemispheric connectivity abnormalities. Previous DTI studies in schizophrenia are inconsistent in reporting decreased Fractional Anisotropy (FA), a measure of anisotropic diffusion, within different portions of the corpus callosum. Moreover, none of these studies has investigated corpus callosum systematically, using anatomical subdivisions. Methods-DTI and structural MRI scans were obtained from 32 chronic schizophrenic subjects and 42 controls. Corpus callosum cross sectional area and its probabilistic subdivisions were determined automatically from structural MRI scans using a model based deformable contour segmentation. These subdivisions employ a previously generated probabilistic subdivision atlas, based on fiber tractography and anatomical lobe subdivision. The structural scan was then coregistered with the DTI scan and the anatomical corpus callosum subdivisions were propagated to the associated FA map. Results-Results revealed decreased FA within parts of the corpus interconnecting frontal regions in schizophrenia compared with controls, but no significant changes for callosal fibers interconnecting parietal and temporo-occipital brain regions. In addition, integrity of the anterior corpus was statistically significantly correlated with negative as well as positive symptoms, while posterior measures correlated with positive symptoms only. Conclusions-This study provides quantitative evidence for a reduction of interhemispheric brain connectivity in schizophrenia, involving corpus callosum, and further points to frontal connections as possibly disrupted in schizophrenia.
Type InteractiveResource
Publisher Elsevier
Journal Title Schizophrenia Research
Volume 106
Issue 2-3
First Page 125
Last Page 131
DOI doi.org/10.1016/j.schres.2008.08.027
Language eng
Bibliographic Citation Kubicki, M., Styner, M., Bouix, S., Gerig, G., Markant, D., Smith, K., Kikinis, R., McCarley, R. W., & Shenton, M. E. (2008). Reduced interhemispheric connectivity in schizophrenia- tractography based segmentation of the corpus callosum. Schizophrenia Research, 106(2-3), 125-31.
Rights Management (c) Elsevier ; Authors manuscript from Kubicki, M., Styner, M., Bouix, S., Gerig, G., Markant, D., Smith, K., Kikinis, R., McCarley, R. W., & Shenton, M. E. (2008). Reduced interhemispheric connectivity in schizophrenia- tractography based segmentation of the corpus callosum. Schizophrenia Research, 106(2-3), 125-31. http://dx.doi.org/10.1016/j.schres.2008.08.027.
Format Medium application/pdf
Identifier uspace, 19236
ARK ark:/87278/s6865rkp
Setname ir_uspace
Date Created 2015-03-09
Date Modified 2015-03-09
ID 712864
Reference URL https://collections.lib.utah.edu/ark:/87278/s6865rkp
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