Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography

Update item information
Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Gilmore, J. H.; Lin, W.; Corouge, I.; Vetsa, Y. S. K.; Smith, J. K.; Kang, C.; Gu, H.; Hamer, R. M.; Lieberman, J. A.
Title Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography
Date 2007-01-01
Description BACKGROUND AND PURPOSE: The early postnatal period is perhaps the most dynamic phase of white matter development. We hypothesized that the early postnatal development of the corpus callosum and corticospinal tracts could be studied in unsedated healthy neonates by using novel approaches to diffusion tensor imaging (DTI) and quantitative tractography. MATERIALS AND METHODS: Isotropic 2 x 2 x 2 mm3 DTI and structural images were acquired from 47 healthy neonates. DTI and structural images were coregistered and fractional anisotropy (FA), mean diffusivity (MD), and normalized T1-weighted (T1W) and T2-weighted (T2W) signal intensities were determined in central midline and peripheral cortical regions of the white matter tracts of the genu and splenium of the corpus callosum and the central midbrain and peripheral cortical regions of the corticospinal tracts by using quantitative tractography. RESULTS: We observed that central regions exhibited lower MD, higher FA values, higher T1W intensity, and lower T2W intensity than peripheral cortical regions. As expected, MD decreased, FA increased, and T2W signal intensity decreased with increasing age in the genu and corticospinal tract, whereas there was no significant change in T1W signal intensity. The central midline region of the splenium fiber tract has a unique pattern, with no change in MD, FA, or T2W signal intensity with age, suggesting different growth trajectory compared with the other tracts. FA seems to be more dependent on tract organization, whereas MD seems to be more sensitive to myelination. CONCLUSIONS: Our novel approach may detect small regional differences and age-related changes in the corpus callosum and corticospinal white matter tracts in unsedated healthy neonates and may be used for future studies of pediatric brain disorders that affect developing white matter.
Type Text
Publisher American Society of Neuroradiology
Volume 28
Issue 9
First Page 1789
Last Page 1795
Language eng
Bibliographic Citation Gilmore, J. H., Lin, W., Corouge, I., Vetsa, Y. S. K., Smith, J. K., Kang, C., Gu, H., Hamer, R. M., Lieberman, J. A., & Gerig, G. (2007). Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography. American Journal of Neuroradiology, 28(9), 1789-95.
Rights Management (c)American Society of Neuroradiology. All Rights Reserved.
Format Medium application/pdf
Format Extent 504,269 bytes
Identifier uspace,19243
ARK ark:/87278/s69343bk
Setname ir_uspace
Date Created 2015-03-06
Date Modified 2015-03-12
ID 712856
Reference URL https://collections.lib.utah.edu/ark:/87278/s69343bk
Back to Search Results