Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain

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Publication Type pre-print
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Creator Gerig, Guido
Other Author Gilmore, John H.; Smith, Lauren C.; Wolfe, Honor M.; Hertzberg, Barbara S.; Smith, J. Keith; Chescheir, Nancy C.; Evans, Dianne D.; Kang, Chaeryon; Hamer, Robert M.; Lin, Weili
Title Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain
Date 2008-01-01
Description Background: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development. Methods: We performed a neonatal MRI on 34 children with isolated mild ventriculomegaly (MVM, width of the atrium of the lateral ventricle ≥ 1.0 cm) on prenatal ultrasound and 34 age and gender matched controls with normal prenatal ventricle size. Lateral ventricle and cortical gray and white matter volumes were assessed. Fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum and cortico-spinal white matter tracts were determined obtained using quantitative tractography . Results: Neonates with prenatal MVM had significantly larger lateral ventricle volumes than matched controls (286.4%; p < 0.0001). Neonates with MVM also had significantly larger intracranial volumes (ICV; 7.1%, p = 0.0063) and cortical gray matter volumes (10.9%, p = 0.0004) compared to controls. DTI tractography revealed a significantly greater MD in the corpus callosum and cortico-spinal tracts, while FA was significantly smaller in several white matter tract regions. Conclusions: Prenatal enlargement of the lateral ventricle is associated with enlargement of the lateral ventricles after birth, as well as greater gray matter volumes and delayed or abnormal maturation of white matter. It is suggested that prenatal ventricle volume is an early structural marker of altered development of the cerebral cortex and may be marker of risk for neuropsychiatric disorders associated with ventricle enlargement.
Type Text
Publisher Elsevier
Volume 64
Issue 12
First Page 1069
Last Page 1076
Language eng
Bibliographic Citation Gilmore, J. H., Smith, L., Wolfe, H. M., Hertzberg, B. S., Smith, J. K., Chescheir, N. C., Evans, D. D., Kang, C., Hamer, R. M., Lin, W., & Gerig, G. (2008). Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain. Biological Psychiatry, 64(12), 1069-76.
Rights Management (c) Elsevier ; Authors manuscript from Gilmore, J. H., Smith, L., Wolfe, H., Hertzberg, B., Smith, J. K., Chescheir, N., Evans, D., Kang, C., Hamer, R. M., Lin, W., & Gerig, G. (2008). Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain. Biological Psychiatry, 64(12), 1069-76. http://dx.doi.org/10.1016/j.biopsych.2008.07.031.
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Identifier uspace,19231
ARK ark:/87278/s66b0cpb
Setname ir_uspace
Date Created 2015-03-06
Date Modified 2021-05-06
ID 712849
Reference URL https://collections.lib.utah.edu/ark:/87278/s66b0cpb
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