Quantitative tract-based white matter development from birth to age 2 years

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358435/
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Links to Media http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358435/
Publication Type journal article
Creator Gerig, Guido
Other Author Geng, Xiujuan; Gouttard, Sylvain; Sharma, Anuja; Gu, Hongbin; Styner, Martin; Lin, Weili; Gilmore, John H.
Title Quantitative tract-based white matter development from birth to age 2 years
Date 2012-01-01
Description Few large-scale studies have been done to characterize the normal human brain white matter growth in the first years of life. We investigated white matter maturation patterns in major fiber pathways in a large cohort of healthy young children from birth to age two using diffusion parameters fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (RD). Ten fiber pathways, including commissural, association and projection tracts, were examined with tract-based analysis, providing more detailed and continuous spatial developmental patterns compared to conventional ROI based methods. All DTI data sets were transformed to a population specific atlas with a group-wise longitudinal large deformation diffeomorphic registration approach. Diffusion measurements were analyzed along the major fiber tracts obtained in the atlas space. All fiber bundles show increasing FA values and decreasing radial and axial diffusivities during the development in the first two years of life. The changing rates of the diffusion indices are faster in the first year than the second year for all tracts. RD and FA show larger percentage changes in the first and second years than AD. The gender effects on the diffusion measures are small. Along different spatial locations of fiber tracts, maturation does not always follow the same speed. Temporal and spatial diffusion changes near cortical regions are in general smaller than changes in central regions. Overall developmental patterns revealed in our study confirm the general rules of white matter maturation. This work shows a promising framework to study and analyze white matter maturation in a tract-based fashion. Compared to most previous studies that are ROI-based, our approach has the potential to discover localized development patterns associated with fiber tracts of interest.
Type InteractiveResource
Publisher Elsevier
Journal Title Neuroimage
Volume 61
Issue 3
First Page 542
Last Page 557
DOI 10.1016/j.neuroimage.2012.03.057
Subject White matter maturation; Axonal myelination; Early brain development; Diffusion properties; DTI atlas; Fiber tracking; Functional regression analysis
Language eng
Bibliographic Citation Geng, X., Gouttard, S., Sharma, A., Gu, H., Styner, M., Lin, W., Gerig, G., & Gilmore, J. H. (2012). Quantitative tract-based white matter development from birth to age 2 years. NeuroImage, 61(3), 542-57.
Rights Management (c) Elsevier ; Authors manuscript from Geng, X., Gouttard, S., Sharma, A., Gu, H., Styner, M., Lin, W., Gerig, G., & Gilmore, J. H. (2012). Quantitative tract-based white matter development from birth to age 2 years. NeuroImage, 61(3), 542-57. http://dx.doi.org/10.1016/j.neuroimage.2012.03.057.
Format Medium application/html
Identifier uspace, 19167
ARK ark:/87278/s6c285kb
Setname ir_uspace
Date Created 2015-02-27
Date Modified 2015-03-06
ID 712840
Reference URL https://collections.lib.utah.edu/ark:/87278/s6c285kb
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