Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the Neonatal Brain

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Publication Type journal article
School or College <blank>
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Creator Gerig, Guido
Other Author Gilmore, John H.; Lin, Weili; Prastawa, Marcel W.; Looney, Christopher B.; Vetsa, Y. Sampath K.; Knickmeyer, Rebecca C.; Evans, Dianne D.; Smith, J. Keith; Hamer, Robert M.; Lieberman, Jeffrey A.
Title Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the Neonatal Brain
Date 2007-01-01
Description Although there has been recent interest in the study of childhood and adolescent brain development, very little is known about normal brain development in the first few months of life. In older children, there are regional differences in cortical gray matter development, whereas cortical gray and white matter growth after birth has not been studied to a great extent. The adult human brain is also characterized by cerebral asymmetries and sexual dimorphisms, although very little is known about how these asymmetries and dimorphisms develop. We used magnetic resonance imaging and an automatic segmentation methodology to study brain structure in 74 neonates in the first few weeks after birth. We found robust cortical gray matter growth compared with white matter growth, with occipital regions growing much faster than prefrontal regions. Sexual dimorphism is present at birth, with males having larger total brain cortical gray and white matter volumes than females. In contrast to adults and older children, the left hemisphere is larger than the right hemisphere, and the normal pattern of fronto-occipital asymmetry described in older children and adults is not present. Regional differences in cortical gray matter growth are likely related to differential maturation of sensory and motor systems compared with prefrontal executive function after birth. These findings also indicate that whereas some adult patterns of sexual dimorphism and cerebral asymmetries are present at birth, others develop after birth.
Type Text
Publisher Society for Neuroscience
Volume 27
Issue 6
First Page 1255
Last Page 1260
Language eng
Bibliographic Citation Gilmore, J. H., Lin, W., Prastawa, M. W., Looney, C. B., Vetsa, Y. S. K., Knickmeyer, R. C., Evans, D. D., Smith, J. K., Hamer, R. M., Lieberman, J. A., & Gerig, G. (2007). Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the Neonatal Brain. Journal of Neuroscience, 27(6), 1255-60.
Rights Management (c) Society for Neuroscience http://www.jneurosci.org/
Format Medium application/pdf
Format Extent 754,521 bytes
Identifier uspace,19254
ARK ark:/87278/s68h1vv3
Setname ir_uspace
Date Created 2015-02-09
Date Modified 2015-02-09
ID 712802
Reference URL https://collections.lib.utah.edu/ark:/87278/s68h1vv3
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