Evaluation of DTI property maps as basis of DTI atlas building

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Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Liu, Zhexing; Goodlett, Casey; Styner, Martin
Title Evaluation of DTI property maps as basis of DTI atlas building
Date 2010-01-01
Description Compared to region of interest based DTI analysis, voxel-based analysis gives higher degree of localization and avoids the procedure of manual delineation with the resulting intra and inter-rater variability. One of the major challenges in voxel-wise DTI analysis is to get high quality voxel-level correspondence. For that purpose, current DTI analysis tools are building on nonlinear registration algorithms that deform individual datasets into a template image that is either precomputed or computed as part of the analysis. A variety of matching criteria and deformation schemes have been proposed, but often comparative evaluation is missing. In our opinion, the use of consistent and unbiased measures to evaluate current DTI procedures is of great importance and our work presents two possible measures. Specifically, we propose the evaluation criteria generalization and specificity, originally introduced by the shape modeling community, to evaluate and compare different DTI nonlinear warping results. These measures are of indirect nature and have a population wise view. Both measures incorporate information of the variability of the registration results in the template space via a voxel-wise PCA model. Thus far, we have used these measures to evaluate our own DTI analysis procedure employing fluid-based registration on scalar DTI maps. Generalization and specificity from tensor images in the template space were computed for 8 scalar property maps. We found that for our procedure an intensity-normalized FA feature outperformed the other scalar measurements. Also, using the tensor images rather than the FA maps as a comparison frame seemed to produce more robust results.
Type Text
Publisher International Society for Optical Engineering (SPIE)
Volume 7623
First Page 762325-1
Last Page 762325-7
Language eng
Bibliographic Citation Liu, Z., Goodlett, C., Gerig, G., & Styner, M. (2010). Evaluation of DTI property maps as basis of DTI atlas building. SPIE Medical Imaging, 7623, 762325-1-762325-7..
Rights Management (c)Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/doi: 10.1117/12.844911.
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Format Extent 191,301 bytes
Identifier uspace,19209
ARK ark:/87278/s6z63z6p
Setname ir_uspace
Date Created 2015-01-30
Date Modified 2021-05-06
ID 712789
Reference URL https://collections.lib.utah.edu/ark:/87278/s6z63z6p