Changes of MR and DTI appearance in early human brain development

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Publication Type pre-print
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Creator Gerig, Guido
Other Author Marc, Cassian; Vachet, Clement; Blocher, Joseph; Gilmore, John; Styner, Martin
Title Changes of MR and DTI appearance in early human brain development
Date 2010-01-01
Description Understanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early development in MRI. 90 neonates were selected from a study of healthy brain development. Subjects were imaged via MRI post-natally. MR acquisition included high-resolution structural and diffusion tensor images. Unbiased atlases for structural and DTI data were generated and co-registered into a single coordinate frame for voxel-wise comparison of MR and DTI appearance across time. All original datasets were mapped into this frame and structural image data was additionally intensity normalized. In addition, myelinated white matter probabilistic segmentations from our neonate tissue segmentation were mapped into the same space to study how our segmentation results were affected by the changing intensity characteristics in early development Linear regression maps and p-value maps were computed and visualized. The resulting visualization of voxelswise corresponding maps of all MR and DTI properties captures early development information in MR imagery. Surprisingly, we encountered regions of seemingly decreased myelinated WM probability over time even though we expected a confident increase for all of the brain. The intensity changes in the MR images in those regions help explain this counterintuitive result. The regressional results indicate that this is an effect of intensity changes due not solely to myelination processes but also likely brain dehydration processes in early postnatal development.
Type Text
Publisher International Society for Optical Engineering (SPIE)
Volume 7623
First Page 762324-1
Last Page 762324-7
Language eng
Bibliographic Citation Marc, C., Vachet, C., Gerig, G., Blocher, J., Gilmore, J., & Styner, M. (2010). Changes of MR and DTI appearance in early human brain development. Proceedings of SPIE Medical Imaging, 7623, 762324-1-762324-7.
Rights Management (c)Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. 10.1117/12.844912.
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ARK ark:/87278/s62z4fpn
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Date Created 2015-01-30
Date Modified 2021-05-06
ID 712788
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