A longitudinal structural MRI study of change in regional contrast in Autism Spectrum Disorder

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Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Vardhan, Avantika; Piven, Joseph; Prastawa, Marcel
Title A longitudinal structural MRI study of change in regional contrast in Autism Spectrum Disorder
Date 2013-01-01
Description Authors: Avantika Vardhan1, Joseph Piven2, Marcel Prastawa3, Guido Gerig3 Institutions: 1Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, United States, 2Dept of Psychiatry, UNC School of Medicine, Chapel Hill, NC, 3University of Utah, Salt Lake City, UT Introduction: The brain undergoes tremendous changes in shape, size, structure, and chemical composition, between birth and 2 years of age [Rutherford, 2001]. Existing studies have focused on morphometric and volumetric changes to study the early developing brain. Although there have been some recent appearance studies based on intensity changes [Serag et al., 2011], these are highly dependent on the quality of normalization. The study we present here uses the changes in contrast between gray and white matter tissue intensities in structural MRI of the brain, as a measure of regional growth [Vardhan et al., 2011]. Kernel regression was used to generate continuous curves characterizing the changes in contrast with time. A statistical analysis was then performed on these curves, comparing two population groups : (i) HR+ : high-risk subjects who tested positive for Autism Spectrum Disorder (ASD), and (ii) HR- : high-risk subjects who tested negative for ASD.
Type Text
Publisher Organization for Human Brain Mapping
First Page 1
Last Page 3
Language eng
Bibliographic Citation Vardhan, A., Piven, J., Prastawa, M., & Gerig, G. (2013). A longitudinal structural MRI study of change in regional contrast in Autism Spectrum Disorder. Proceedings of the 19th Annual Meeting of the Organization for Human Brain Mapping OHBM, 1-3.
Rights Management (c) Organization for Human Brain Mapping
Format Medium application/pdf
Format Extent 331,466 bytes
Identifier uspace,19121
ARK ark:/87278/s6rn6j0s
Setname ir_uspace
Date Created 2015-01-12
Date Modified 2015-01-12
ID 712775
Reference URL https://collections.lib.utah.edu/ark:/87278/s6rn6j0s
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