Spatiotemporal modeling of distribution-valued data applied to DTI tract evolution in infant neurodevelopment

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Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Sharma, Anuja; Fletcher, P. Thomas; Gilmore, John H.; Escolar, Maria L.; Vardhan, Avantika; Gupta, Aditya; Styner, Martin
Title Spatiotemporal modeling of distribution-valued data applied to DTI tract evolution in infant neurodevelopment
Date 2013-01-01
Description This paper proposes a novel method that extends spatiotemporal growth modeling to distribution-valued data. The method relaxes assumptions on the underlying noise models by considering the data to be represented by the complete probability distributions rather than a representative, single-valued summary statistics like the mean. When summarizing by the latter method, information on the underlying variability of data is lost early in the process and is not available at later stages of statistical analysis. The concept of 'distance' between distributions and an 'average' of distributions is employed. The framework quantifies growth trajectories for individuals and populations in terms of the complete data variability estimated along time and space. Concept is demonstrated in the context of our driving application which is modeling of age-related changes along white matter tracts in early neurodevelopment. Results are shown for a single subject with Krabbe's disease in comparison with a normative trend estimated from 15 healthy controls.
Type Text
Publisher Institute of Electrical and Electronics Engineers (IEEE)
First Page 684
Last Page 687
Language eng
Bibliographic Citation Sharma, A., Fletcher, P. T., Gilmore, J. H., Escolar, M. L., Vardhan, A., Gupta, A., Styner, M., & Gerig, G. (2013). Spatiotemporal modeling of distribution-valued data applied to DTI tract evolution in infant neurodevelopment. Proceedings of the 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI), 684-7.
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Format Medium application/pdf
Format Extent 1,105,080 bytes
Identifier uspace,19118
ARK ark:/87278/s632350b
Setname ir_uspace
Date Created 2014-12-29
Date Modified 2015-01-06
ID 712757
Reference URL https://collections.lib.utah.edu/ark:/87278/s632350b
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