3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants

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Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Paniaguia. Beatriz; Emodi, Omri; Hill, Jonathan; Fishbaugh, James; Pimenta, Luiz A.; Aylward, Stephen R.; Andinet, Enquobahrie.; Gilmore, John; Van Aalst, John A.; Styner, Martin
Title 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants
Date 2013-01-01
Description The skull of young children is made up of bony plates that enable growth. Craniosynostosis is a birth defect that causes one or more sutures on an infant's skull to close prematurely. Corrective surgery focuses on cranial and orbital rim shaping to return the skull to a more normal shape. Functional problems caused by craniosynostosis such as speech and motor delay can improve after surgical correction, but a post-surgical analysis of brain development in comparison with age-matched healthy controls is necessary to assess surgical outcome. Full brain segmentations obtained from pre- and post-operative computed tomography (CT) scans of 8 patients with single suture sagittal (n=5) and metopic (n=3), non-syndromic craniosynostosis from 41 to 452 days-of-age were included in this study. Age-matched controls obtained via 4D acceleration-based regression of a cohort of 402 full brain segmentations from healthy controls magnetic resonance images (MRI) were also used for comparison (ages 38 to 825 days). 3D point-based models of patient and control cohorts were obtained using SPHARM-PDM shape analysis tool. From a full dataset of regressed shapes, 240 healthy regressed shapes between 30 and 588 days-of-age (time step = 2.34 days) were selected. Volumes and shape metrics were obtained for craniosynostosis and healthy age-matched subjects. Volumes and shape metrics in single suture craniosynostosis patients were larger than age-matched controls for pre- and post-surgery. The use of 3D shape and volumetric measurements show that brain growth is not normal in patients with single suture craniosynostosis.
Type Text
Publisher International Society for Optical Engineering (SPIE)
Volume 8672
First Page 86720V-1
Last Page 86720V-8
Language eng
Bibliographic Citation Paniaguia. B., Emodi, O., Hill, J., Fishbaugh, J., Pimenta, L. A., Aylward, S. R., Andinet, E., Gerig, G., Gilmore, J., Van Aalst, J. A., & Styner, M. (2013). 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants. Proceedings of SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 8672, 86720V-1-86720V-8.
Rights Management (c)Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/doi: 10.1117/12.2006524.
Format Medium application/pdf
Format Extent 772,976 bytes
Identifier uspace,19000
ARK ark:/87278/s6hf14s0
Setname ir_uspace
Date Created 2014-11-06
Date Modified 2014-11-06
ID 712715
Reference URL https://collections.lib.utah.edu/ark:/87278/s6hf14s0
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