Paternal age and genetic load

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Publication Type pre-print
School or College College of Social & Behavioral Science
Department Anthropology
Creator Harpending, Henry C.
Other Author Cochran, Gregory
Title Paternal age and genetic load
Date 2013-01-01
Description The incidence of base substitutions in humans increases with the age of the father, which shows up as an increased incidence of mutational disorders in the children of older fathers. There is a less obvious implication: an extended period of high average paternal age in a population will lead to increased genetic load. We mention some societies that have had high average paternal age for many generations. This may explain some surprising regional differences in recent measurements of deleterious mutations. High average paternal age also influences life history evolution, strengthening selection against mortality in late life while weakening selection against child mortality.
Type Text
Publisher Wayne State University Press
Volume 85
Issue 4
First Page 515
Last Page 527
Language eng
Bibliographic Citation Cochran, G., & Harpending, H. (2013). Paternal age and genetic load. Human Biology, 85(4), 515-27.
Rights Management (c)Wayne State University Press (doi: 10.3378/027.085.0401)
Format Medium application/pdf
Format Extent 202,791 bytes
Identifier uspace,18428
ARK ark:/87278/s6x09h2d
Setname ir_uspace
Date Created 2014-03-28
Date Modified 2021-05-06
ID 712052
Reference URL