Pituitary models

Update item information
Publication Type pre-print
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Sivakumar, Walavan
Title Pituitary models
Date 2013-01-01
Description Pituitary tumor animal models provide researchers a microenvironment that simulates the clinical situation; however, in comparison with astrocytoma and meningioma tumor research where intracranial xenograft transplantations are increasingly being used to test various therapeutic modalities, in vivo therapeutic research on pituitary animal models focuses on direct drug therapy to the tumor because of the lack of established intracranial pituitary tumor models. The rat subcutaneous prolactin-secreting pituitary model allows investigators to noninvasively measure tumor size and the effect of direct tumor-guided therapy in a serial manner and is considered biologically relevant because it has proven to be histologically, immunocytochemically, and ultrastructurally consistent with human pituitary tumors.
Type Text
Publisher Springer
Volume 77
First Page 175
Last Page 179
Language eng
Bibliographic Citation Sivakumar, W., & Couldwell, W. T. (2013). Pituitary models. Neuromethods, 77, 175-9.
Rights Management (c) Springer (The original publication is available at www.springerlink.com) ; DOI: 10.1007/7657_2011_28.
Format Medium application/pdf
Format Extent 798,202 bytes
Identifier uspace,18157
ARK ark:/87278/s6tf0g5g
Setname ir_uspace
Date Created 2013-03-22
Date Modified 2013-03-22
ID 708345
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tf0g5g
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