Publication Type |
pre-print |
School or College |
College of Engineering |
Department |
Mechanical Engineering |
Creator |
Gale, Bruce K. |
Other Author |
Lin, Keng-Min; Sant, Himanshu J.; Agarwal, Jayant P. |
Title |
New approaches to bridge nerve gaps: Development of a novel drug-delivering nerve conduit |
Date |
2012-01-01 |
Description |
Contemporary bridging techniques for repairing nerve gaps caused by trauma require autologous nerve grafts, which are difficult to harvest and handle and result in significant donor site deficit. Several nerve conduits with axon growth-enhancing potential have been proposed, developed and tested over the past fifteen years. In this work, prototypes of a nerve conduit designed to bridge large nerve gaps (≥10mm) end-to-end were incorporated with concentric drug reservoirs for constant and controlled drug delivery to enhance axon growth. These devices were designed, fabricated and tested in vitro in amber glass vials with bovine serum albumin in order to determine the drug release kinetics for future application. Our devices have shown the capability to deliver the drug of interest over a 6-day period. |
Type |
Text |
Publisher |
Institute of Electrical and Electronics Engineers (IEEE) |
First Page |
747 |
Last Page |
750 |
Dissertation Institution |
University of Utah |
Language |
eng |
Bibliographic Citation |
Lin, K.-M., Sant, H. J., Gale, B. K., & Agarwal, J. P. (2012). New approaches to bridge nerve gaps: Development of a novel drug-delivering nerve conduit. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, no.6346039, 747-50. |
Rights Management |
(c) 2012 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. |
Format Medium |
application/pdf |
Format Extent |
679,690 bytes |
Identifier |
uspace,18135 |
ARK |
ark:/87278/s6086q3k |
Setname |
ir_uspace |
ID |
708305 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6086q3k |