The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking

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Publication Type pre-print
School or College School of Medicine
Department Ophthalmology
Creator Frederick, Jeanne M.
Other Author Zhang, Houbin; Constantine, Ryan; Baehr, Wolfgang
Title The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking
Date 2012-01-01
Description Expressed ubiquitously, PrBP/d functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/d features an immunoglobulin-like b-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/d binds both C-terminal C15 and C20 prenyl side chains of phototransduction polypeptides and small GTP-binding (G) proteins of the Ras superfamily. PrBP/d also interacts with the small GTPases, ARL2 and ARL3, which act as release factors (GDFs) for prenylated cargo. Targeted deletion of the mouse Pde6d gene encoding PrBP/d resulted in impeded trafficking to the outer segments of GRK1 and cone PDE6 which are predicted to be farnesylated and geranylgeranylated, respectively. Rod and cone transducin trafficking was largely unaffected. These trafficking defects produce progressive cone-rod dystrophy in the Pde6d/ mouse.
Type Text
Publisher Elsevier
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Zhang, H., Constantine, R., Frederick, J. M., & Baehr, W. (2012). The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking. Vision Research.
Rights Management (c) Elsevier ; Reprinted from Zhang, H., Constantine, R., Frederick, J. M., & Baehr, W. (2012). The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking. Vision Research. http://dx.doi.org/DOI: 10.1016/j.visres.2012.08.013.
Format Medium application/pdf
Format Extent 1,767,519 bytes
Identifier uspace,18014
ARK ark:/87278/s6n30fq7
Setname ir_uspace
Date Created 2013-01-25
Date Modified 2013-01-25
ID 708300
Reference URL https://collections.lib.utah.edu/ark:/87278/s6n30fq7
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